INT8793

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Context Info
Confidence 0.75
First Reported 1992
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 58
Total Number 59
Disease Relevance 26.36
Pain Relevance 7.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
CD86 5
B cells 5
DCs 3
macrophages 2
brain 2
H2 (Mus musculus)
Pain Link Frequency Relevance Heat
lidocaine 7 99.88 Very High Very High Very High
Hippocampus 50 99.68 Very High Very High Very High
antinociception 5 99.52 Very High Very High Very High
Intracerebroventricular 1 99.32 Very High Very High Very High
Inflammation 315 99.06 Very High Very High Very High
drug abuse 12 99.00 Very High Very High Very High
cytokine 326 98.80 Very High Very High Very High
tail-flick 1 97.40 Very High Very High Very High
Serotonin 275 97.28 Very High Very High Very High
Central nervous system 181 96.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Influenza Virus Infection 286 99.84 Very High Very High Very High
Sprains And Strains 179 99.84 Very High Very High Very High
Urological Neuroanatomy 12 99.84 Very High Very High Very High
Infection 792 99.60 Very High Very High Very High
Diabetes Mellitus-type I 9 99.44 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 56 99.40 Very High Very High Very High
Alzheimer's Dementia 80 99.38 Very High Very High Very High
Diabetes Mellitus 23 99.20 Very High Very High Very High
Viral Meningitis 25 99.12 Very High Very High Very High
INFLAMMATION 434 99.06 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemical staining of the skin revealed that the phagocytes exhibited expression of MHC-II molecules (Fig. 1D).
Gene_expression (expression) of MHC-II in phagocytes
1) Confidence 0.75 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2543000 Disease Relevance 0.12 Pain Relevance 0
As for the concentration of H2, it was reported that H2 dissolved in arterial blood was increased by the inhalation of H2 in proportion to the concentration inhaled, from 0 to 4%, together with O2 and N2O; the amount of H2 dissolved in venous blood was less than that in artery blood, suggesting that H2 had been incorporated into tissues [1].
Gene_expression (inhalation) of H2 in blood
2) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 0.25 Pain Relevance 0.12
It increased immediately when the rats started to inhale the H2 gas and reached a plateau within 10 minutes (0.22 ppm; 110 µM), but decreased soon after stopping inhalation (t1/2?
Gene_expression (gas) of H2
3) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 0 Pain Relevance 0
increase observed is associated with increased antigen presentation in the TGRUN animals, who expressed significantly more MHC II than TGSED (p = 0.04) (Figure 4).
Gene_expression (expressed) of MHC II
4) Confidence 0.23 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2329612 Disease Relevance 0.13 Pain Relevance 0.14
We further suggest that exercise induces a microglial phenotype shift from a macrophagic phenotype to an antigen presenting phenotype, expressing CD11c and MHC II.
Gene_expression (expressing) of MHC II
5) Confidence 0.23 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2329612 Disease Relevance 0.72 Pain Relevance 0.05
TGSED, we examined CD40 and MHC II protein expression in the hippocampus via western blot.
Spec (examined) Gene_expression (expression) of MHC II in hippocampus associated with hippocampus
6) Confidence 0.23 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2329612 Disease Relevance 0 Pain Relevance 0.17
Specifically, the expression levels of CD40, CD80, CD86 and MHC II were evaluated in unlabeled, SPIO-loaded and PMA-activated B cells via flow cytometry, Fig. 1D.
Gene_expression (expression) of MHC II in B cells
7) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871797 Disease Relevance 0.09 Pain Relevance 0.13
Internalization did not significantly alter morphology, lead to clumping, or affect the surface expression patterns of isolated B cells as assessed by the measurement of CD40, CD80, CD86 and MHC II expression by immunostaining and flow cytometry.
Gene_expression (expression) of MHC II in B cells
8) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871797 Disease Relevance 0.19 Pain Relevance 0.10
It was found that LPS mediated a similar increase in the expression of CD40, CD80, CD86 and MHC II for both SPIO-labeled and unlabeled B cells (Fig. 1E).
Gene_expression (expression) of MHC II in B cells
9) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871797 Disease Relevance 0.06 Pain Relevance 0.15
Treatment of apoE deficient SCs with recombinant mouse interferon-gamma and lipopolysaccharide resulted in higher MHC-II and CD40 expression as compared with normal SCs derived from wild-type mice.
Gene_expression (expression) of MHC-II in SCs
10) Confidence 0.22 Published 2007 Journal Glia Section Abstract Doc Link 17357152 Disease Relevance 0.89 Pain Relevance 0.40
The increased MHC-II and CD40 expression on SCs was accompanied by lower levels of intracellular IL-6 production within SCs of apoE deficiency, which is confirmed by the neutralization with anti IL-6 antibody.
Gene_expression (expression) of MHC-II in SCs
11) Confidence 0.22 Published 2007 Journal Glia Section Abstract Doc Link 17357152 Disease Relevance 0.90 Pain Relevance 0.41
The MHC II blots confirm that the IFN-?
Gene_expression (blots) of MHC II
12) Confidence 0.20 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2329612 Disease Relevance 0.14 Pain Relevance 0.15
Co-expression of Env, CD11c and MHC-II on splenic DCs was assessed by flow cytometry 8, 15 and 35 post-infection after preparation of splenocytes from sacrificed mice.


Gene_expression (Co-expression) of MHC-II associated with infection
13) Confidence 0.19 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2883599 Disease Relevance 0.10 Pain Relevance 0
The antigen presenting response is characterized by CD11c positive cells, MHC II, and CD40.
Gene_expression (positive) of MHC II
14) Confidence 0.18 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2329612 Disease Relevance 0.44 Pain Relevance 0.07
Heritabilities (h2) and phenotypic variances (?
Gene_expression (Heritabilities) of h2
15) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2962628 Disease Relevance 0 Pain Relevance 0
Specifically, the expression levels of CD40, CD80, CD86 and MHC II were evaluated in unlabeled, SPIO-loaded and PMA-activated B cells via flow cytometry, Fig. 1D.
Gene_expression (levels) of MHC II in B cells
16) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871797 Disease Relevance 0.09 Pain Relevance 0.13
The microneedle vaccine formulated with trehalose (MN+T) showed the highest levels of MHC II peptide-specific IFN-?
Gene_expression (levels) of MHC II
17) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2745577 Disease Relevance 0.93 Pain Relevance 0.05
CD8 splenocytes were also clonally deleted, providing evidence for intrathymic deletion taking place because mature superantigen-reactive CD8 cells—in contrast to CD4 cells—are not deleted extrathymically (as they do not efficiently bind to the superantigen-presenting MHC II), but only intrathymically at the double positive stage of development (Figure 6B).
Gene_expression (presenting) of MHC II
18) Confidence 0.14 Published 2010 Journal American Journal of Transplantation Section Body Doc Link PMC2856406 Disease Relevance 0.19 Pain Relevance 0
ApoE-deficient mice were observed to reduce the expression of intracellular IL-6 accompanied with higher levels of MHC II and CD 40 expression on SCs.
Gene_expression (expression) of MHC II
19) Confidence 0.12 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 0.56 Pain Relevance 0.50
When cultured in the absence of AMs, aDC upregulated expression of CD86, MHC II and CD40.
Gene_expression (expression) of MHC II in CD86
20) Confidence 0.12 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2762542 Disease Relevance 0.34 Pain Relevance 0

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