INT87932

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Context Info
Confidence 0.69
First Reported 2000
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 28
Total Number 30
Disease Relevance 8.86
Pain Relevance 16.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cnr1) aging (Cnr1) plasma membrane (Cnr1)
signal transducer activity (Cnr1)
Anatomy Link Frequency
dentate gyrus 6
central nervous system 4
dorsal horn 4
interneurons 4
paw 4
Cnr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Cannabinoid 923 100.00 Very High Very High Very High
agonist 504 100.00 Very High Very High Very High
tolerance 305 100.00 Very High Very High Very High
antagonist 163 100.00 Very High Very High Very High
Cannabinoid receptor 92 100.00 Very High Very High Very High
Opioid 69 100.00 Very High Very High Very High
Cancer pain 11 99.92 Very High Very High Very High
analgesia 175 99.40 Very High Very High Very High
Analgesic 439 99.34 Very High Very High Very High
Pain 65 99.34 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer Pain 11 99.92 Very High Very High Very High
Bone Cancer 12 99.82 Very High Very High Very High
Targeted Disruption 44 99.42 Very High Very High Very High
Nervous System Injury 36 99.26 Very High Very High Very High
Epilepsy 261 98.76 Very High Very High Very High
INFLAMMATION 14 98.32 Very High Very High Very High
Neurodegenerative Disease 249 98.12 Very High Very High Very High
Status Epilepticus 185 97.44 Very High Very High Very High
Congenital Anomalies 2 93.88 High High
Neuroblastoma 3 92.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increases in CB1R expression were shown in the hippocampus, if not in the dentate gyrus, in other models of TLE [31], [56], [57], and receptor levels appear to change biphasically in the whole hippocampus over time after SE, being reduced initially and then increased over several weeks [29].
Positive_regulation (Increases) of Gene_expression (expression) of CB1R in hippocampus associated with epilepsy, status epilepticus and hippocampus
1) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871782 Disease Relevance 0.64 Pain Relevance 0.36
We used Western blot to minimize this issue and detected an increase in the total CB1R protein expression in the temporal half of the isolated dentate gyrus of pilocarpine-treated epileptic mice with robust mossy fiber sprouting.
Positive_regulation (increase) of Gene_expression (expression) of CB1R in dentate gyrus associated with epilepsy
2) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871782 Disease Relevance 0.53 Pain Relevance 0.22
However, in contrast to nerve injury, bone cancer was associated with an increase of CB1 receptor expression in the DRGs [12] as previously shown for inflammatory models [13], suggesting that normalization of AEA disturbances through FAAH inhibition may be even more effective in the relief of cancer pain than neuropathic pain.
Positive_regulation (increase) of Gene_expression (expression) of CB1 receptor in nerve associated with nervous system injury, cancer pain, inflammation, neuropathic pain and bone cancer
3) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2869361 Disease Relevance 1.30 Pain Relevance 0.88
Reduction of bone cancer pain by activation of spinal cannabinoid receptor 1 and its expression in the superficial dorsal horn of the spinal cord in a murine model of bone cancer pain.
Positive_regulation (activation) of Gene_expression (expression) of cannabinoid receptor 1 in dorsal horn associated with cannabinoid receptor, cancer pain, analgesic, dorsal horn, bone cancer and spinal cord
4) Confidence 0.50 Published 2009 Journal Anesthesiology Section Title Doc Link 19512863 Disease Relevance 0.77 Pain Relevance 1.05
These results indicate that CB1 activation is necessary during training but not during testing, and that the decreased predisposition observed in CB1 knockout mice is not likely attributable to developmental abnormalities or altered CB1 signaling during feeding on the devaluation test.
Neg (not) Positive_regulation (necessary) of Gene_expression (activation) of CB1 associated with targeted disruption and congenital anomalies
5) Confidence 0.50 Published 2008 Journal Frontiers in Neuroscience Section Body Doc Link PMC2622741 Disease Relevance 0.41 Pain Relevance 0.17
We used recently generated conditional mutant mice for the CB1 receptor, bearing a deletion of the CB1 gene in principal neurons (defined as projecting neurons as opposed to interneurons, independently of their neurochemical characteristics, normally expressing Ca2+/calmodulin-dependent kinase II?
Positive_regulation (bearing) of Gene_expression (receptor) of CB1 in interneurons
6) Confidence 0.50 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2001214 Disease Relevance 0 Pain Relevance 0.35
9-tetrahydrocannabinol (THC) exert a plethora of psychoactive effects through the activation of the neuronal cannabinoid receptor type 1 (CB1), which is expressed by different neuronal subpopulations in the central nervous system.
Positive_regulation (activation) of Gene_expression (expressed) of CB1 in central nervous system associated with cannabinoid receptor and central nervous system
7) Confidence 0.50 Published 2007 Journal PLoS Biology Section Abstract Doc Link PMC2001214 Disease Relevance 0.08 Pain Relevance 0.28
We used recently generated conditional mutant mice for the CB1 receptor, bearing a deletion of the CB1 gene in principal neurons (defined as projecting neurons as opposed to interneurons, independently of their neurochemical characteristics, normally expressing Ca2+/calmodulin-dependent kinase II?
Positive_regulation (generated) of Gene_expression (receptor) of CB1 in interneurons
8) Confidence 0.50 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2001214 Disease Relevance 0 Pain Relevance 0.35
We tested locomotor, hypothermic, analgesic, and cataleptic effects of THC in conditional knockout mouse lines, which lack the expression of CB1 in different neuronal subpopulations, including principal brain neurons, GABAergic neurons (those that release ?
Positive_regulation (subpopulations) of Gene_expression (expression) of CB1 in GABAergic neurons associated with targeted disruption, gabaergic and analgesic
9) Confidence 0.50 Published 2007 Journal PLoS Biology Section Abstract Doc Link PMC2001214 Disease Relevance 0.10 Pain Relevance 0.36
However, while spatial resolution is limited with the Western blot technique, these results were consistent with our electrophysiological data indicating an increase in CB1R-dependent suppression of local glutamatergic synaptic connections, probably between granule cells.
Positive_regulation (increase) of Gene_expression (suppression) of CB1R-dependent in granule cells
10) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871782 Disease Relevance 0.42 Pain Relevance 0.19
These findings indicate that activation of CB1R present on nerve terminals can suppress recurrent excitation in the dentate gyrus of mice with TLE.
Positive_regulation (activation) of Gene_expression (present) of CB1R in dentate gyrus associated with epilepsy
11) Confidence 0.50 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2871782 Disease Relevance 0.68 Pain Relevance 0.57
Since effects were seen in animals with mossy fiber sprouting but not control animals, we reasoned that the newly sprouted axon terminals expressed CB1R and this may result in an increase in CB1R protein expression in the dentate gyrus of pilocarpine-treated mice that survived SE.
Positive_regulation (increase) of Gene_expression (expression) of CB1R in dentate gyrus associated with status epilepticus
12) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871782 Disease Relevance 0.51 Pain Relevance 0.07
Cannabinoid agonists, such as methanandamide, which apparently do not activate Gq/11 proteins [16,17], produced desensitization of CB1Rs via activation of Gz proteins.
Positive_regulation (activation) of Gene_expression (produced) of CB1Rs associated with cannabinoid and agonist
13) Confidence 0.50 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657119 Disease Relevance 0 Pain Relevance 0.84
Agonists of CB1Rs do not promote stable transfer of G proteins to RGS proteins
Positive_regulation (Agonists) of Gene_expression (Agonists) of CB1Rs associated with agonist
14) Confidence 0.50 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657119 Disease Relevance 0.06 Pain Relevance 0.90
We then analyzed a series of mechanisms that could be responsible for this CB1R tolerance.


Positive_regulation (responsible) of Gene_expression (tolerance) of CB1R associated with tolerance
15) Confidence 0.50 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657119 Disease Relevance 0 Pain Relevance 1.06
However, the connection between CB1R and MOR persisted when the expression of G?
Positive_regulation (between) of Gene_expression (connection) of CB1R
16) Confidence 0.50 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657119 Disease Relevance 0 Pain Relevance 1.67
We next wanted to know, whether CB1 receptor expression would also be necessary to elicit the effects of RUN and ENR on adult neurogenesis

Activity-induced neurogenesis is absent in CB1-/- mice

Spec (whether) Positive_regulation (necessary) of Spec (whether) Gene_expression (expression) of CB1 receptor associated with neurodegenerative disease
17) Confidence 0.50 Published 2010 Journal Cell Commun Signal Section Body Doc Link PMC2898685 Disease Relevance 0.26 Pain Relevance 0.04
This supported our result from immunohistochemistry with regard to the expression of CB1 on neuronal progenitor cells.
Positive_regulation (supported) of Gene_expression (expression) of CB1 in neuronal
18) Confidence 0.50 Published 2010 Journal Cell Commun Signal Section Body Doc Link PMC2898685 Disease Relevance 0.24 Pain Relevance 0.05
This implies that CB1 expression would increase with the degree of differentiation from type-2b cells onwards.


Positive_regulation (increase) of Gene_expression (expression) of CB1
19) Confidence 0.50 Published 2010 Journal Cell Commun Signal Section Body Doc Link PMC2898685 Disease Relevance 0.22 Pain Relevance 0
In immunohistochemical experiments, although mu-opioid receptor 1 expression was reduced in the superficial dorsal horn ipsilateral to the site of implantation of sarcoma cells, CB1 expression was preserved.
Positive_regulation (preserved) of Gene_expression (expression) of CB1 in dorsal horn
20) Confidence 0.47 Published 2009 Journal Anesthesiology Section Body Doc Link 19512863 Disease Relevance 0.13 Pain Relevance 0

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