INT8794

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Context Info
Confidence 0.57
First Reported 1990
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 35
Total Number 35
Disease Relevance 6.44
Pain Relevance 14.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cofactor metabolic process (Ppt1) Golgi apparatus (Ppt1) cytosol (Ppt1)
extracellular space (Ppt1) protein modification process (Ppt1) extracellular region (Ppt1)
Anatomy Link Frequency
striatum 6
radial 1
cervical region 1
muscles 1
TMJ 1
Ppt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 36 100.00 Very High Very High Very High
Pain threshold 15 100.00 Very High Very High Very High
Hyperalgesia 13 99.70 Very High Very High Very High
Snapping jaw 11 99.58 Very High Very High Very High
Enkephalin 76 99.56 Very High Very High Very High
Nucleus accumbens 8 99.56 Very High Very High Very High
Inflammation 16 98.92 Very High Very High Very High
Dopamine 55 98.56 Very High Very High Very High
Pain 43 98.20 Very High Very High Very High
Calcitonin gene-related peptide 3 97.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 44 100.00 Very High Very High Very High
Postpartum Thyroiditis 6 100.00 Very High Very High Very High
Injury 16 99.92 Very High Very High Very High
Hyperalgesia 27 99.70 Very High Very High Very High
Temporomandibular Joint Syndrome 11 99.58 Very High Very High Very High
INFLAMMATION 16 98.92 Very High Very High Very High
Aging 6 98.50 Very High Very High Very High
Neck Pain 12 98.20 Very High Very High Very High
Inflammatory Pain 10 94.76 High High
Thyroid Disease 4 91.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Meanwhile, age decreased the PPT mRNA by 27 and 24% in 10- and 23-month-old rats, respectively.
Negative_regulation (decreased) of PPT mRNA
1) Confidence 0.57 Published 1998 Journal Neurosci. Lett. Section Abstract Doc Link 9622201 Disease Relevance 0.17 Pain Relevance 0.04
In the pCPA/QA group, striatal PPE and PPT mRNA levels were further reduced as compared to the saline/QA group with PPE mRNA reductions reaching statistical significance at 95% (ANOVA with Scheffe F-test).
Negative_regulation (reduced) of PPT mRNA
2) Confidence 0.57 Published 1996 Journal Brain Res. Section Abstract Doc Link 9017251 Disease Relevance 0.06 Pain Relevance 0.16
The decrease in PPT-A mRNA levels induced by the neonatal DA lesion was not changed after SR46349B treatment in the posterior part of the lesioned striatum.
Negative_regulation (decrease) of PPT in striatum associated with dopamine
3) Confidence 0.57 Published 2002 Journal J. Neurosci. Res. Section Abstract Doc Link 11754083 Disease Relevance 0 Pain Relevance 0.49
Cortical transections did not significantly affect the 6-OHDA-lesion-induced down-regulation of PPT mRNA in any of the striatal regions analysed.
Negative_regulation (down-regulation) of PPT mRNA
4) Confidence 0.57 Published 1994 Journal Eur. J. Neurosci. Section Abstract Doc Link 7981878 Disease Relevance 0 Pain Relevance 0.34
The present results demonstrate that knife-cut transections of the frontal corticostriatal pathway are capable of reversing the increased striatal PPE mRNA levels, but not the decreased PPT mRNA levels, induced by a 6-OHDA lesion of the dopaminergic input.
Neg (not) Negative_regulation (decreased) of PPT mRNA
5) Confidence 0.57 Published 1994 Journal Eur. J. Neurosci. Section Abstract Doc Link 7981878 Disease Relevance 0 Pain Relevance 0.33
At 48 h post-QA injection, PPT and PPE mRNAs were markedly reduced within the striatal lesion site of saline/QA and pCPA/QA groups with respect to their contralateral uninjected control sides.
Negative_regulation (reduced) of PPT
6) Confidence 0.50 Published 1996 Journal Brain Res. Section Abstract Doc Link 9017251 Disease Relevance 0.06 Pain Relevance 0.15
RESULTS: The analysis of variance showed that PPT levels were significantly bilaterally decreased over both trigeminal (supra-orbital, infra-orbital, and mental) and nontrigeminal (median, ulnar, and radial) nerves in children with FETTH as compared with control subjects (all sites, P < .001).
Negative_regulation (decreased) of PPT in radial
7) Confidence 0.43 Published 2010 Journal Pediatrics Section Body Doc Link 20530075 Disease Relevance 0.08 Pain Relevance 0
The results showed that PPT levels were significantly decreased bilaterally over the masseter, temporalis, and upper trapezius muscles, and also the C5-C6 zygapophyseal joint (P < .001), but not over the tibialis anterior muscle (P = .4) in patients with mechanical chronic neck pain when compared to controls.
Negative_regulation (decreased) of PPT in muscles associated with pain and neck pain
8) Confidence 0.43 Published 2010 Journal J Pain Section Abstract Doc Link 19945351 Disease Relevance 0.88 Pain Relevance 0.88
The PPT mRNA decreased by 21% after the haloperidol treatment in young rats only.
Negative_regulation (decreased) of PPT mRNA
9) Confidence 0.42 Published 1998 Journal Neurosci. Lett. Section Abstract Doc Link 9622201 Disease Relevance 0.16 Pain Relevance 0.03
It is concluded that there is a difference in the effects of aging on the response of PPek and PPT mRNA contents to haloperidol and that the loss of PPT mRNA response in 10- and 23-month-old rats might be due to the change of dopamine system of the striatum in these rats.
Negative_regulation (loss) of PPT mRNA in striatum associated with dopamine and aging
10) Confidence 0.42 Published 1998 Journal Neurosci. Lett. Section Abstract Doc Link 9622201 Disease Relevance 0.17 Pain Relevance 0.05
Lesions of the dopaminergic striatal afferents resulted in marked increases in the mRNA encoding PPE throughout the striatum, including the ventral striatum and nucleus accumbens, while the levels of PPT mRNA were considerably reduced in these structures.
Negative_regulation (reduced) of PPT mRNA in striatum associated with nucleus accumbens
11) Confidence 0.42 Published 1994 Journal Eur. J. Neurosci. Section Abstract Doc Link 7981878 Disease Relevance 0 Pain Relevance 0.28
The downregulation of striatal PPT mRNA in the lesioned striatum was reversed only by apomorphine.
Negative_regulation (downregulation) of PPT in striatum
12) Confidence 0.39 Published 1996 Journal J Neural Transm Section Abstract Doc Link 8739837 Disease Relevance 0 Pain Relevance 0.58
Eight hours after a single injection, striatal PPT and PPE mRNA levels were significantly reduced.
Negative_regulation (reduced) of PPT
13) Confidence 0.38 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1380083 Disease Relevance 0 Pain Relevance 0.98
There was a greater magnitude of PPT decrease within trigeminal nerves as compared with nontrigeminal nerves (P < .03).
Negative_regulation (decrease) of PPT in nerves
14) Confidence 0.37 Published 2010 Journal Pediatrics Section Body Doc Link 20530075 Disease Relevance 0.07 Pain Relevance 0
PPT decreased from the ridge crest to the buccal vestibule.
Negative_regulation (decreased) of PPT in crest
15) Confidence 0.37 Published 2004 Journal J Dent Section Body Doc Link 15001287 Disease Relevance 0.08 Pain Relevance 0
The magnitude of PPT decreases was greater in the cervical region as compared to the trigeminal region (P < .01).
Negative_regulation (decreases) of PPT in cervical region
16) Confidence 0.37 Published 2010 Journal J Pain Section Abstract Doc Link 19945351 Disease Relevance 1.13 Pain Relevance 1.07
Within the CTTH group, neither increased tenderness nor decreased PPT seemed to directly influence headache intensity, frequency or duration; or vice versa.
Neg (nor) Negative_regulation (decreased) of PPT
17) Confidence 0.37 Published 2007 Journal Clin J Pain Section Body Doc Link 17449996 Disease Relevance 0.21 Pain Relevance 0
RESULTS: CTTH patients showed decreased PPT and increased tenderness as compared with controls (P<0.001).
Negative_regulation (decreased) of PPT
18) Confidence 0.37 Published 2007 Journal Clin J Pain Section Body Doc Link 17449996 Disease Relevance 0.24 Pain Relevance 0
At 24 hr, the level of PPE had returned to control level whereas that of PPT mRNA remained depressed.
Negative_regulation (depressed) of PPT
19) Confidence 0.32 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1380083 Disease Relevance 0 Pain Relevance 0.99
In saline treated 6-OHDA lesioned animals PPE mRNA was elevated (+160%, p < 0.005) and PPT mRNA decreased (-36%, p < 0.005) in the denervated striatum.
Negative_regulation (decreased) of PPT in striatum
20) Confidence 0.29 Published 1996 Journal J Neural Transm Section Abstract Doc Link 8739837 Disease Relevance 0 Pain Relevance 0.54

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