INT87942

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Context Info
Confidence 0.68
First Reported 2000
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 12
Total Number 13
Disease Relevance 3.98
Pain Relevance 4.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (LOC500077)
Anatomy Link Frequency
brain 3
spinal cord 2
visceral 1
peripheral nerve 1
trunk 1
LOC500077 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 18 100.00 Very High Very High Very High
Peripheral nerve stimulation 1 99.98 Very High Very High Very High
Pain 25 99.80 Very High Very High Very High
narcan 5 99.70 Very High Very High Very High
Somatosensory cortex 60 98.32 Very High Very High Very High
primary somatosensory cortex 7 96.74 Very High Very High Very High
opiate 2 96.48 Very High Very High Very High
Analgesic 3 92.84 High High
medulla 7 91.04 High High
anesthesia 13 90.92 High High
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

126 99.04 Very High Very High Very High
Pain 20 98.70 Very High Very High Very High
Cyst 1 96.76 Very High Very High Very High
Urological Neuroanatomy 5 94.92 High High
Neurologic Manifestations 1 93.04 High High
Sleep Disorders 4 92.48 High High
Cognitive Disorder 5 91.76 High High
Congenital Anomalies 7 90.04 High High
Neuropathic Pain 5 87.28 High High
Injury 3 86.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SSEPs were distorted and smaller in amplitude, and fMRI activation was significantly weaker in the lesioned hemisphere.
Positive_regulation (activation) of fMRI
1) Confidence 0.68 Published 2004 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 15625415 Disease Relevance 0.19 Pain Relevance 0.32
Areas of fMRI activation in the spinal cord correspond well with spinal cord physiology.
Positive_regulation (activation) of fMRI in spinal cord associated with spinal cord
2) Confidence 0.60 Published 2007 Journal Neuroimage Section Abstract Doc Link 17204434 Disease Relevance 0 Pain Relevance 0.81
Symptomatic patients showed a significant reduction in their ability to perceive coherent visual motion compared with controls, whereas the asymptomatic patients did not show this effect. fMRI activation was similar during random dot motion in all three groups, but was significantly decreased during coherent dot motion in the symptomatic patients compared with the other two groups.
Positive_regulation (activation) of fMRI
3) Confidence 0.46 Published 2001 Journal Neurorehabil Neural Repair Section Abstract Doc Link 11527277 Disease Relevance 0.67 Pain Relevance 0.14
In conclusion, the experiments provide evidence that peripheral nerve stimulation induces a fMRI signal in the respective division of the somatosensory cortex in a stimulus-related manner.
Positive_regulation (induces) of fMRI in peripheral nerve associated with somatosensory cortex and peripheral nerve stimulation
4) Confidence 0.39 Published 2000 Journal Exp. Neurol. Section Abstract Doc Link 11085890 Disease Relevance 0.09 Pain Relevance 0.15
Under spontaneous respiration, a global decrease in fMRI signal was observed; under artificial respiration, a region-specific increase in fMRI signal was identified and the activation sites are consistent with the distribution of opiate mu-receptors in rat brain as previously reported by autoradiography.
Positive_regulation (increase) of fMRI in brain associated with opiate
5) Confidence 0.38 Published 2000 Journal Neuroreport Section Abstract Doc Link 10790887 Disease Relevance 0 Pain Relevance 0.29
Although levels of fMRI signals in SI of the trunk territory were not significantly different between normal and spinally injured non-hypersensitive rats, the administration of naloxone significantly increased fMRI signals in the non-hypersensitive rats, but not in the normal rats.
Neg (not) Positive_regulation (increased) of fMRI in trunk associated with primary somatosensory cortex and narcan
6) Confidence 0.32 Published 2008 Journal Pain Section Abstract Doc Link 18258366 Disease Relevance 0.77 Pain Relevance 0.96
Absence of increasing cortical fMRI activity volume in response to increasing visceral stimulation in IBS patients.
Positive_regulation (increasing) of fMRI in visceral
7) Confidence 0.27 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Title Doc Link 15246969 Disease Relevance 0.32 Pain Relevance 0.23
Increased fMRI signal occurred in 7 regions common to both groups, and decreased signal was observed in 1 common region.
Positive_regulation (Increased) of fMRI
8) Confidence 0.21 Published 2002 Journal Arthritis Rheum. Section Body Doc Link 12115241 Disease Relevance 0.06 Pain Relevance 0
Each FM patient underwent fMRI while moderately painful pressure was being applied.
Positive_regulation (underwent) of fMRI
9) Confidence 0.21 Published 2002 Journal Arthritis Rheum. Section Body Doc Link 12115241 Disease Relevance 0.09 Pain Relevance 0
Spinal cord is an important relay of the pain pathway, and fMRI offers an excellent opportunity to quantify pain using activation in the spinal cord induced by painful stimuli. fMRI literature of cervical spinal cord with regard to the spatial extent, in both longitudinal and cross-sectional directions, of neuronal activation induced by noxious stimulation is ambiguous.
Positive_regulation (induced) of fMRI in spinal cord associated with pain and spinal cord
10) Confidence 0.17 Published 2009 Journal Neuroimage Section Abstract Doc Link 18835453 Disease Relevance 0.45 Pain Relevance 0.99
Finally, although CRD can trigger contraction of the anal sphincter, and contraction of this sphincter also induces brain fMRI activity, in the current study external anal sphincter contraction was not measured but the level of fMRI activity was likely identical in both CORT and CHOL-treated rats in response to CRD.
Positive_regulation (induces) of fMRI in brain
11) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797306 Disease Relevance 0 Pain Relevance 0.26
We focused our analysis to structures identified by fMRI as activated in response to 40 mmHg CRD in CORT-implanted rats but not activated in CHOL controls as these brain sites may be pivotal for the sensitization of visceral responses (Table 1 and 2).
Neg (not) Positive_regulation (activated) of fMRI in brain
12) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797306 Disease Relevance 0.08 Pain Relevance 0.16
These differences may explain why fMRI activations only partly overlap.
Positive_regulation (activations) of fMRI
13) Confidence 0.01 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2605917 Disease Relevance 0.26 Pain Relevance 0.23

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