INT87959

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Context Info
Confidence 0.63
First Reported 2000
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.37
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Ptgs1) aging (Ptgs1) Golgi apparatus (Ptgs1)
endoplasmic reticulum (Ptgs1) cytoplasm (Ptgs1) lipid binding (Ptgs1)
Ptgs1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 7 98.52 Very High Very High Very High
Inflammation 1 75.00 Quite High
COX2 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Enteropathy 3 98.52 Very High Very High Very High
INFLAMMATION 2 98.02 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: These studies allow dissociation of the contribution and consequences of uncoupling of mitochondrial oxidative phosphorylation and cyclooxygenase inhibition in the pathophysiology of NSAID enteropathy.
Phosphorylation (phosphorylation) of cyclooxygenase
1) Confidence 0.63 Published 2000 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 10792129 Disease Relevance 0 Pain Relevance 0
Uncoupling of intestinal mitochondrial oxidative phosphorylation and inhibition of cyclooxygenase are required for the development of NSAID-enteropathy in the rat.
Phosphorylation (phosphorylation) of cyclooxygenase associated with enteropathy and cinod
2) Confidence 0.63 Published 2000 Journal Aliment. Pharmacol. Ther. Section Title Doc Link 10792129 Disease Relevance 0.10 Pain Relevance 0.20
The pathogenesis of nonsteroidal anti-inflammatory drug (NSAID) enteropathy is a complex process involving the uncoupling of mitochondrial oxidative phosphorylation and inhibition of cyclooxygenase (COX).
Phosphorylation (phosphorylation) of cyclooxygenase associated with inflammation, enteropathy and cinod
3) Confidence 0.36 Published 2004 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 15060699 Disease Relevance 0.27 Pain Relevance 0.31

General Comments

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