INT87969

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Context Info
Confidence 0.41
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 15
Total Number 20
Disease Relevance 10.67
Pain Relevance 8.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
motor nerve 1
sensory nerve 1
upper limb 1
Cts (Mus musculus)
Pain Link Frequency Relevance Heat
carpal tunnel syndrome 1480 100.00 Very High Very High Very High
Demyelination 15 96.48 Very High Very High Very High
Action potential 75 86.16 High High
alcohol 5 79.68 Quite High
Pain 15 44.88 Quite Low
Hypoesthesia 5 44.56 Quite Low
peripheral neuropathy 5 41.84 Quite Low
Inflammation 5 21.56 Low Low
Sciatica 10 20.92 Low Low
ischemia 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Carpal Tunnel Syndrome 1672 100.00 Very High Very High Very High
Demyelinating Disease 15 96.48 Very High Very High Very High
Occupational Diseases 14 95.04 Very High Very High Very High
Disease 38 93.68 High High
Injury 72 93.16 High High
Motor Neuron Diseases 45 83.00 Quite High
Neuropathic Pain 98 75.84 Quite High
Cv Unclassified Under Development 19 57.96 Quite High
Cadaver 14 51.36 Quite High
Pain 15 44.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Only studies with a prospective design and a focus on the association between repetitive work and CTS as defined above were included.
CTS Binding (association) of associated with carpal tunnel syndrome
1) Confidence 0.41 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2569035 Disease Relevance 0.62 Pain Relevance 0.44
Also of concern was the observation that associations with the most specific CTS case definition were not as strong as associations with the less specific CTS case definition.
CTS Binding (associations) of associated with carpal tunnel syndrome
2) Confidence 0.41 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2569035 Disease Relevance 0.44 Pain Relevance 0.44
Supplementary to the epidemiological evidence of the risk of computer work, longitudinal studies of the association between CTS and high repetition and low force work were identified with the search terms 'carpal tunnel syndrome and repet*' (Pubmed only).
CTS Binding (association) of associated with carpal tunnel syndrome
3) Confidence 0.41 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2569035 Disease Relevance 0.56 Pain Relevance 0.56
In all, results from studies on other kinds of repetitive, low force work and CTS did not add to evidence of to an association between computer use and CTS.


CTS Binding (association) of associated with carpal tunnel syndrome
4) Confidence 0.41 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2569035 Disease Relevance 0.54 Pain Relevance 0.54
Also of concern was the observation that associations with the most specific CTS case definition were not as strong as associations with the less specific CTS case definition.
CTS Binding (associations) of associated with carpal tunnel syndrome
5) Confidence 0.32 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2569035 Disease Relevance 0.45 Pain Relevance 0.45
Several engineering interventions positively influenced risk factors associated with CTS, but the evaluations did not measure disease incidence.
CTS Binding (associated) of
6) Confidence 0.31 Published 2000 Journal Am J Prev Med Section Body Doc Link 10793280 Disease Relevance 0.05 Pain Relevance 0
Because of some similarities between computer work and repetitive, low force work, studies examining associations between repetitive work and CTS were also evaluated (longitudinal studies only).
CTS Binding (associations) of associated with carpal tunnel syndrome
7) Confidence 0.31 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2569035 Disease Relevance 0.67 Pain Relevance 0.40
The epidemiological evidence of an association between computer use and CTS is inconsistent.
CTS Binding (association) of associated with carpal tunnel syndrome
8) Confidence 0.31 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2569035 Disease Relevance 0.34 Pain Relevance 0.34
Thus, the core of this review was a detailed evaluation of the existing epidemiological evidence of an association between computer work and CTS.
CTS Binding (association) of associated with carpal tunnel syndrome
9) Confidence 0.31 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2569035 Disease Relevance 0.62 Pain Relevance 0.41
In the literature search on the association between computer work and CTS 4661 references were identified (Figure 1).
CTS Binding (association) of associated with carpal tunnel syndrome
10) Confidence 0.31 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2569035 Disease Relevance 0.26 Pain Relevance 0.26
When statistical tests were applied to the results presented by Stevens et al., a statistically significant positive association was observed for the association between mouse use and CTS (although the authors concluded otherwise) [9].
CTS Binding (association) of associated with carpal tunnel syndrome
11) Confidence 0.31 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2569035 Disease Relevance 0.29 Pain Relevance 0.29
The issue was partly addressed in a recent review where it was concluded that the evidence did not point at any important association between keyboard and computer work and CTS [3].
CTS Binding (association) of associated with carpal tunnel syndrome
12) Confidence 0.31 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2569035 Disease Relevance 0.92 Pain Relevance 0.57
Eight epidemiological studies of the association between computer work and CTS were identified.
CTS Binding (association) of associated with carpal tunnel syndrome
13) Confidence 0.31 Published 2008 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC2569035 Disease Relevance 0.60 Pain Relevance 0.54
All 8 studies identified in this review that examined the association between computer work and CTS had important limitations.
CTS Spec (examined) Binding (association) of associated with carpal tunnel syndrome
14) Confidence 0.31 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2569035 Disease Relevance 0.36 Pain Relevance 0.36
The identification of epidemiological studies examining associations between computer work and CTS began with a search in the following databases: Pubmed, Embase, Web of Science, and Arbline.
CTS Binding (associations) of associated with carpal tunnel syndrome
15) Confidence 0.31 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2569035 Disease Relevance 0.70 Pain Relevance 0.35
Overall, DQEMG appears sensitive enough to determine differences in MUP amplitudes between groups of individuals with and without motor nerve impairment associated with CTS, but in the current study there were no significant differences in measures of MUP stability.
CTS Binding (associated) of in motor nerve associated with carpal tunnel syndrome
16) Confidence 0.14 Published 2010 Journal J Neuroeng Rehabil Section Body Doc Link PMC2928769 Disease Relevance 0.10 Pain Relevance 0.10
CTS: carpal tunnel syndrome; ABP: Abductor Pollicis Brevis; DQEMG: decomposition-based quantitative electromyography; EMG: electromyographyl; RMS: root mean square; MU: motor unit; MUP: needle-detected motor unit potential; MUPT: motor unit potential train; MUNE: motor unit number estimate; MVC: maximal voluntary contraction; SMUP: surface-detected motor unit potential; CMAP: compound muscle action potential; CNAP: compound nerve action potential; ALS: amyotrophic lateral sclerosis; SNAP: sensory nerve action potential; RMSMVC: RMS value of the MVC.


CTS Binding (syndrome) of in sensory nerve associated with action potential, carpal tunnel syndrome and motor neuron diseases
17) Confidence 0.14 Published 2010 Journal J Neuroeng Rehabil Section Body Doc Link PMC2928769 Disease Relevance 0.89 Pain Relevance 0.77
Only the affected upper limb was tested in individuals with CTS.
CTS Binding (individuals) of in upper limb associated with carpal tunnel syndrome
18) Confidence 0.14 Published 2010 Journal J Neuroeng Rehabil Section Body Doc Link PMC2928769 Disease Relevance 0.42 Pain Relevance 0.41
This result is not surprising since sensory loss is normally experienced before motor loss in CTS and as such, the sensory losses experienced in subjects with mild CTS would be similar to those sustained by individuals with severe CTS.
CTS Binding (individuals) of associated with carpal tunnel syndrome
19) Confidence 0.14 Published 2010 Journal J Neuroeng Rehabil Section Body Doc Link PMC2928769 Disease Relevance 1.08 Pain Relevance 0.96
Similarly, the Ajiggle, shimmerCov and fibre count (Table 4) data did not demonstrate any significant differences among the three groups (p > 0.05), but did show trends whereby the amount of Ajiggle and ShimmerCov increased with severity of CTS.


CTS Binding (severity) of associated with carpal tunnel syndrome
20) Confidence 0.14 Published 2010 Journal J Neuroeng Rehabil Section Body Doc Link PMC2928769 Disease Relevance 0.77 Pain Relevance 0.77

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