INT87973

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.58
First Reported 2000
Last Reported 2010
Negated 4
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 0.33
Pain Relevance 1.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Cnr1) plasma membrane (Cnr1) response to stress (Cnr1)
signal transducer activity (Cnr1)
Anatomy Link Frequency
globus pallidus 4
brain 2
dopaminergic neurons 2
substantia nigra 1
caudate-putamen 1
Cnr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 22 100.00 Very High Very High Very High
Cannabinoid 13 100.00 Very High Very High Very High
Cannabinoid receptor 4 100.00 Very High Very High Very High
anesthesia 1 99.92 Very High Very High Very High
agonist 10 98.56 Very High Very High Very High
substance P 4 94.56 High High
Dopamine 4 93.20 High High
imagery 2 92.40 High High
amygdala 62 91.36 High High
Substantia nigra 8 88.48 High High
Disease Link Frequency Relevance Heat
Anxiety Disorder 122 97.60 Very High Very High Very High
Disease 2 95.24 Very High Very High Very High
Stress 42 50.00 Quite Low
Post-traumatic Stress Disorder 16 5.00 Very Low Very Low Very Low
Shock 7 5.00 Very Low Very Low Very Low
Cognitive Disorder 6 5.00 Very Low Very Low Very Low
Injury 3 5.00 Very Low Very Low Very Low
Phobia 3 5.00 Very Low Very Low Very Low
Hyperalgesia 1 5.00 Very Low Very Low Very Low
Overactive Bladder 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In summary, the unilateral 6-hydroxydopamine lesion of nigrostriatal dopaminergic neurons originated a marked increase in CB1 receptor-mRNA levels in cell bodies of striatal efferent neurons, although accompanied by no changes in CB1 receptor binding and activation of signal transduction mechanisms.
Neg (no) Regulation (changes) of CB1 Binding (binding) of in dopaminergic neurons
1) Confidence 0.58 Published 2000 Journal Life Sci. Section Abstract Doc Link 10794065 Disease Relevance 0 Pain Relevance 0.12
The effect of anaesthesia on [(18)F]MK-9470 binding to the type 1 cannabinoid receptor in the rat brain.
Regulation (effect) of type 1 cannabinoid receptor Binding (binding) of in brain associated with anesthesia and cannabinoid receptor
2) Confidence 0.27 Published 2010 Journal Eur. J. Nucl. Med. Mol. Imaging Section Title Doc Link 20182714 Disease Relevance 0.10 Pain Relevance 0.28
We did not find any significant changes in CB1 receptor binding, measured by [3H]WIN-55,212,2 autoradiography, or in the activation of signal transduction mechanisms, measured by WIN-55,212,2-stimulated [35S]GTPgammaS binding autoradiography, between the lesioned and nonlesioned sides at the level of the lateral caudate-putamen, globus pallidus and substantia nigra in both groups of lesioned rats.
Neg (not) Regulation (changes) of CB1 Binding (binding) of in globus pallidus associated with substantia nigra
3) Confidence 0.26 Published 2000 Journal Life Sci. Section Abstract Doc Link 10794065 Disease Relevance 0 Pain Relevance 0.19
Recently, Azad et al. [99] have shown that CB1 receptors reduce GABA-ergic synaptic transmission in the amygdale, and consequently facilitate
Regulation (facilitate) of CB1 Binding (receptors) of associated with gaba and cannabinoid
4) Confidence 0.22 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1838961 Disease Relevance 0.24 Pain Relevance 0.60
We did not find any significant changes in CB1 receptor binding, measured by [3H]WIN-55,212,2 autoradiography, or in the activation of signal transduction mechanisms, measured by WIN-55,212,2-stimulated [35S]GTPgammaS binding autoradiography, between the lesioned and nonlesioned sides at the level of the lateral caudate-putamen, globus pallidus and substantia nigra in both groups of lesioned rats.
Neg (not) Regulation (changes) of CB1 in caudate-putamen Binding (binding) of in globus pallidus associated with substantia nigra
5) Confidence 0.09 Published 2000 Journal Life Sci. Section Abstract Doc Link 10794065 Disease Relevance 0 Pain Relevance 0.19
We did not find any significant changes in CB1 receptor binding, measured by [3H]WIN-55,212,2 autoradiography, or in the activation of signal transduction mechanisms, measured by WIN-55,212,2-stimulated [35S]GTPgammaS binding autoradiography, between the lesioned and nonlesioned sides at the level of the lateral caudate-putamen, globus pallidus and substantia nigra in both groups of lesioned rats.
Neg (not) Regulation (changes) of CB1 in substantia nigra Binding (binding) of in globus pallidus associated with substantia nigra
6) Confidence 0.09 Published 2000 Journal Life Sci. Section Abstract Doc Link 10794065 Disease Relevance 0 Pain Relevance 0.19
Indole ring substitutions had varying effects on CB 2 and CB 1 binding, but were generally detrimental to agonist activity.
Regulation (effects) of CB 1 Binding (binding) of associated with agonist
7) Confidence 0.01 Published 2008 Journal J. Med. Chem. Section Abstract Doc Link 18311894 Disease Relevance 0 Pain Relevance 0.30

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox