INT87974

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Context Info
Confidence 0.65
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 2.51
Pain Relevance 4.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Cnr1) plasma membrane (Cnr1) response to stress (Cnr1)
signal transducer activity (Cnr1)
Anatomy Link Frequency
caudate-putamen 2
uterine 2
myometrium 1
decidua 1
hippocampus 1
Cnr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cannabinoid 104 100.00 Very High Very High Very High
agonist 68 99.96 Very High Very High Very High
dorsal root ganglion 4 99.56 Very High Very High Very High
Thermal hyperalgesia 2 98.48 Very High Very High Very High
Enkephalin 3 98.30 Very High Very High Very High
Inflammation 24 97.64 Very High Very High Very High
cytokine 10 97.28 Very High Very High Very High
Hippocampus 3 96.56 Very High Very High Very High
Substantia nigra 6 96.48 Very High Very High Very High
Cannabinoid receptor 68 94.20 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 5 99.56 Very High Very High Very High
Overactive Bladder 25 99.12 Very High Very High Very High
Hyperalgesia 10 98.48 Very High Very High Very High
INFLAMMATION 25 97.64 Very High Very High Very High
Sprains And Strains 6 89.16 High High
Nociception 18 87.60 High High
Stress 57 79.20 Quite High
Death 15 76.32 Quite High
Cadaver 1 73.68 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

30 72.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, we found a significant increase in levels of CB1 receptor-mRNA transcripts, measured by in situ hybridization, in the lesioned side in both the lateral and medial caudate-putamen.
Transcription (transcripts) of CB1 in medial
1) Confidence 0.65 Published 2000 Journal Life Sci. Section Abstract Doc Link 10794065 Disease Relevance 0 Pain Relevance 0.15
Buckley et al. described CB1 and CB2 receptor mRNAs in the outer longitudinal layer and in the inner circular layer of myometrium of the pregnant rat uterus [38].
Transcription (described) of CB1 in myometrium
2) Confidence 0.64 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2775033 Disease Relevance 0.28 Pain Relevance 0.08
The mRNA expression of the CB1 receptor was significantly higher than that of the CB2 receptor in both tissue types (P < 0.05).
Transcription (expression) of CB1 receptor
3) Confidence 0.56 Published 2010 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2878434 Disease Relevance 0.41 Pain Relevance 0.21
1) Detection of CB1R messenger RNA expression
Transcription (expression) of CB1R
4) Confidence 0.53 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2912121 Disease Relevance 0.24 Pain Relevance 0.07
Unilateral 6-hydroxydopamine lesions of nigrostriatal dopaminergic neurons increased CB1 receptor mRNA levels in the caudate-putamen.
Transcription (levels) of CB1 in caudate-putamen associated with enkephalin
5) Confidence 0.50 Published 2000 Journal Life Sci. Section Title Doc Link 10794065 Disease Relevance 0 Pain Relevance 0.25
Figure 1 shows the relative levels of transcripts for CB1, CB2 and TRPV1 in the uterine maternal tissues from day 10 to day 19 of pregnancy.
Transcription (transcripts) of CB1 in uterine
6) Confidence 0.49 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2775033 Disease Relevance 0 Pain Relevance 0
CB1, CB2 and TRPV1 mRNA levels
Transcription (levels) of CB1
7) Confidence 0.49 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2775033 Disease Relevance 0 Pain Relevance 0
The relative abundance of CB1, CB2 and TRPV1 protein in the mesometrial decidua throughout pregnancy was also evaluated by immunoblotting (Figure 2).
Transcription (abundance) of CB1 in decidua
8) Confidence 0.49 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2775033 Disease Relevance 0 Pain Relevance 0
We used Q-PCR and western blot to demonstrate transcript and protein levels throughout pregnancy for the anandamide-binding receptors CB1, CB2 and TRPV1, and uterine tissue, distribution of these receptors was revealed by immunohistochemistry.
Transcription (transcript) of CB1 in uterine
9) Confidence 0.49 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2775033 Disease Relevance 0 Pain Relevance 0.24
In situ hybridization showed normal CB1 mRNA expression in 28% of DRG neurons.
Transcription (expression) of CB1 in neurons associated with dorsal root ganglion
10) Confidence 0.48 Published 2006 Journal Pain Section Abstract Doc Link 16709443 Disease Relevance 1.01 Pain Relevance 0.88
In situ hybridization studies revealed that, compared with Wistar rats, msP animals have consistently greater cannabinoid CB1 receptor mRNA expression in a number of brain areas, including the frontoparietal cortex, caudate-putamen and hippocampus (CA1 and dentate gyrus areas).
Transcription (expression) of CB1 receptor in cortex associated with cannabinoid and hippocampus
11) Confidence 0.47 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 15869521 Disease Relevance 0.17 Pain Relevance 0.58
Rats were trained to discriminate the cannabinoid CB1 receptor agonist CP 55,940 (either 0.03 or 0.014 mg/kg, i.p., t=30 min) from vehicle, in a two-lever food-reinforced procedure, and were subsequently tested with the three compounds.
Transcription (discriminate) of CB1 receptor in lever associated with cannabinoid and agonist
12) Confidence 0.44 Published 2003 Journal Behav Pharmacol Section Abstract Doc Link 14501260 Disease Relevance 0 Pain Relevance 0.25
However, we found a significant increase in levels of CB1 receptor-mRNA transcripts, measured by in situ hybridization, in the lesioned side in both the lateral and medial caudate-putamen.
Transcription (transcripts) of CB1 in lateral
13) Confidence 0.22 Published 2000 Journal Life Sci. Section Abstract Doc Link 10794065 Disease Relevance 0 Pain Relevance 0.15
In situ hybridization studies revealed that, compared with Wistar rats, msP animals have consistently greater cannabinoid CB1 receptor mRNA expression in a number of brain areas, including the frontoparietal cortex, caudate-putamen and hippocampus (CA1 and dentate gyrus areas).
Transcription (expression) of CB1 receptor in caudate-putamen associated with cannabinoid and hippocampus
14) Confidence 0.16 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 15869521 Disease Relevance 0.17 Pain Relevance 0.58
In situ hybridization studies revealed that, compared with Wistar rats, msP animals have consistently greater cannabinoid CB1 receptor mRNA expression in a number of brain areas, including the frontoparietal cortex, caudate-putamen and hippocampus (CA1 and dentate gyrus areas).
Transcription (expression) of CB1 receptor in hippocampus associated with cannabinoid and hippocampus
15) Confidence 0.16 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 15869521 Disease Relevance 0.17 Pain Relevance 0.58

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