INT87976

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Context Info
Confidence 0.58
First Reported 2000
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 9
Total Number 15
Disease Relevance 6.87
Pain Relevance 7.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Cnr1) plasma membrane (Cnr1) response to stress (Cnr1)
signal transducer activity (Cnr1)
Anatomy Link Frequency
Visceral 4
neurons 4
striatum 2
brain 2
corneal nerves 2
Cnr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cannabinoid 134 100.00 Very High Very High Very High
agonist 132 100.00 Very High Very High Very High
Cannabinoid receptor 70 100.00 Very High Very High Very High
antagonist 63 100.00 Very High Very High Very High
Serotonin 12 100.00 Very High Very High Very High
Dopamine 11 100.00 Very High Very High Very High
Opioid 9 100.00 Very High Very High Very High
Enkephalin 7 100.00 Very High Very High Very High
fluoxetine 5 100.00 Very High Very High Very High
dopamine receptor 1 99.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 287 99.96 Very High Very High Very High
Nociception 40 99.54 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

150 98.26 Very High Very High Very High
Hypersensitivity 53 98.16 Very High Very High Very High
INFLAMMATION 84 97.76 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

10 97.60 Very High Very High Very High
Convulsion 18 96.24 Very High Very High Very High
Colitis 10 94.54 High High
Colon Disease 5 93.52 High High
Dyspepsia 75 92.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This supports a critical role for dopamine in the control of CB1 receptor gene expression.
Regulation (role) of Gene_expression (expression) of CB1 associated with dopamine
1) Confidence 0.58 Published 2000 Journal Life Sci. Section Abstract Doc Link 10794065 Disease Relevance 0 Pain Relevance 0.11
Stress-induced up-regulation of CB1R expression in the large and small intestine
Regulation (regulation) of Gene_expression (expression) of CB1R in small intestine associated with stress
2) Confidence 0.45 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2912121 Disease Relevance 1.09 Pain Relevance 0.41
Recent data indicate a protective function of up-regulated endocannabinoid levels in colitis.38,27 In rats and guinea pigs, besides an expression in cholinergic myenteric neurons, a close association between CB1R immunoreactivity and fibers labeled for a synaptic protein has been described, suggesting a role in the modulation of transmitter release.39 Similarly, expression of CB1Rs has been found to be up-regulated in rats during an experimental intestinal inflammation.26,40
Regulation (be) of Gene_expression (expression) of CB1Rs in neurons associated with colitis, endocannabinoid and inflammation
3) Confidence 0.45 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2912121 Disease Relevance 1.19 Pain Relevance 0.47
Recent data indicate a protective function of up-regulated endocannabinoid levels in colitis.38,27 In rats and guinea pigs, besides an expression in cholinergic myenteric neurons, a close association between CB1R immunoreactivity and fibers labeled for a synaptic protein has been described, suggesting a role in the modulation of transmitter release.39 Similarly, expression of CB1Rs has been found to be up-regulated in rats during an experimental intestinal inflammation.26,40
Regulation (found) of Gene_expression (expression) of CB1Rs in neurons associated with colitis, endocannabinoid and inflammation
4) Confidence 0.45 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2912121 Disease Relevance 1.19 Pain Relevance 0.47
Visceral nociceptive response to chronic PR stress: effect of peripheral treatment with the CB1R agonist and antagonist
Regulation (effect) of Gene_expression (agonist) of CB1R in Visceral associated with stress, nociception, antagonist and agonist
5) Confidence 0.45 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2912121 Disease Relevance 1.12 Pain Relevance 0.30
The presence of immunoreactive TRPV1 in uNK cells was observed from day 10 until degranulation, contrary to CB1 expression that diminishes around day 12.
Regulation (degranulation) of Gene_expression (expression) of CB1
6) Confidence 0.42 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2775033 Disease Relevance 0.23 Pain Relevance 0.07
4) or mixed CB1 and CB2 receptor antagonists followed by saline vehicle on days 14 and 15 (n?
Regulation (followed) of Gene_expression (antagonists) of CB1 associated with antagonist
7) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2878341 Disease Relevance 0 Pain Relevance 0.31
Pretreatment with the CB1 and CB2 cannabinoid receptor antagonists N-piperidino-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-3-pyrazole-carboxamide (SR141716) and N-[1S)-endo-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]-5-(4-chloro-3-methylphenyl)-1-(4-methylbenzyl)-pyrazole-3-carboxamide (SR144528) did not affect the responses to anandamide.
Regulation (affect) of Gene_expression (Pretreatment) of CB1 associated with cannabinoid receptor and antagonist
8) Confidence 0.27 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12538826 Disease Relevance 0.39 Pain Relevance 0.86
CB1Rs mediating the analgesic effect on visceral pain induced by colorectal distension was shown in a recent research.18 It might helpful to determine whether there are any changes in CB1Rs expression associated with underlying pathology.
Spec (whether) Regulation (changes) of Gene_expression (expression) of CB1Rs in visceral associated with visceral pain and analgesic
9) Confidence 0.27 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2912121 Disease Relevance 0.60 Pain Relevance 0.65
This supports a critical role for dopamine in the control of CB1 receptor gene expression.
Regulation (control) of Gene_expression (expression) of CB1 associated with dopamine
10) Confidence 0.26 Published 2000 Journal Life Sci. Section Abstract Doc Link 10794065 Disease Relevance 0 Pain Relevance 0.11
This study examines the effect of intravenous self-administration (SA) of either heroin or the cannabinoid receptor agonist WIN 55,212-2 on levels and functionality of mu-opioid (MOR) and CB1-cannabinoid receptors (CB1R) in reward-related brain areas, such as the prefrontal cortex (PFC), nucleus accumbens (NAc), caudate putamen (CP), hippocampus (Hippo), amygdala (Amy), hypothalamus (Hypo) and ventral tegmental area (VTA). [3H]DAMGO and [3H]CP-55,940 autoradiography and agonist-stimulated [35S]GTPgammaS binding were performed on brain sections of rats firmly self-administering heroin or WIN 55,212-2.
Spec (examines) Regulation (effect) of in brain Gene_expression (levels) of CB1R in NAc associated with ventral tegmentum, nucleus accumbens, cannabinoid receptor, agonist, hippocampus, amygdala and opioid
11) Confidence 0.26 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17419755 Disease Relevance 0 Pain Relevance 0.92
The function of CB1 expression on corneal nerves is not known.
Regulation (function) of Gene_expression (expression) of CB1 in corneal nerves
12) Confidence 0.23 Published 2002 Journal Pain Section Abstract Doc Link 12406531 Disease Relevance 0 Pain Relevance 0.54
The up-regulated CB1 receptor gene expression in our study is in line with earlier studies, in which CB1 receptors were up-regulated after seizures in adult rats [99], [100].
Regulation (regulated) of Gene_expression (expression) of CB1 associated with convulsion
13) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873964 Disease Relevance 0.60 Pain Relevance 0.53
This study examined the time course effects (8, 16 and 31 days) of fluoxetine administration (1 mg/kg, p.o.
Spec (examined) Regulation (effects) of Gene_expression (expressions) of CB1 receptor in brain associated with fluoxetine
14) Confidence 0.16 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15936043 Disease Relevance 0 Pain Relevance 0.79
Expression and function of CB1 receptor in the rat striatum: localization and effects on D1 and D2 dopamine receptor-mediated motor behaviors.
Regulation (effects) of Gene_expression (Expression) of CB1 receptor in striatum associated with dopamine receptor and enkephalin
15) Confidence 0.03 Published 2008 Journal Neuropsychopharmacology Section Title Doc Link 17957223 Disease Relevance 0 Pain Relevance 0.95

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