INT87985

Context Info Confidence 0.67 First Reported 2000 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 1.52 Pain Relevance 1.37

transferase activity, transferring glycosyl groups (Dpagt1) endoplasmic reticulum (Dpagt1)

Anatomy Link Frequency liver 1 Dpagt1 (Mus musculus)

Pain Link Frequency Relevance Heat Glutamate 1 100.00 Paracetamol 12 97.80 Inflammation 6 95.12 Analgesic 4 82.52

Disease Link Frequency Relevance Heat Arthritis 2 98.16 Toxicity 3 97.80 Injury 1 97.64 Granuloma 1 96.40 INFLAMMATION 6 95.12 Pressure And Volume Under Development 1 91.92 Necrosis 1 87.44 Hepatotoxicity 2 82.20 Stress 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

P. niruri significantly reduced the elevated glutamate pyruvate transaminase (GPT) and alkaline phosphatase (ALP) levels in the sera of toxicity induced mice, compared with the control group.

Positive_regulation (elevated) of GPT associated with toxicity and glutamate

1) Confidence 0.67 Published 2006 Journal Phytother Res Section Abstract Doc Link 16718736 Disease Relevance 0.36 Pain Relevance 0.43

Solanum alatum treatment (100 mg/kg, p.o.) decreased the elevation of serum alanine aminotransferase (ALT; GPT) and aspartate aminotransferase (AST; GOT) induced by acetaminophen (paracetamol) (600 mg/kg, i.p.) administration.

Positive_regulation (elevation) of GPT associated with paracetamol

2) Confidence 0.45 Published 2000 Journal Am. J. Chin. Med. Section Abstract Doc Link 10794122 Disease Relevance 0.26 Pain Relevance 0.45

Further, the product inhibited the increased level of serum lysosomal enzyme activity viz. serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, alkaline phosphatase and the lipid peroxidation in liver.

Positive_regulation (increased) of serum lysosomal enzyme in liver

3) Confidence 0.01 Published 2007 Journal Indian J. Exp. Biol. Section Abstract Doc Link 17373374 Disease Relevance 0.89 Pain Relevance 0.49

General Comments

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