INT87988

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Context Info
Confidence 0.77
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 9.75
Pain Relevance 1.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (ASAH1) lipid metabolic process (ASAH1)
Anatomy Link Frequency
adult mouse 1
ASAH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 27 100.00 Very High Very High Very High
Inflammation 34 94.20 High High
Pain 7 85.00 Quite High
peripheral neuropathy 2 78.88 Quite High
headache 1 78.60 Quite High
Spinal cord 2 68.56 Quite High
metalloproteinase 3 5.00 Very Low Very Low Very Low
psoriasis 3 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Motor Neuron Diseases 88 100.00 Very High Very High Very High
Hypercalcemia 38 100.00 Very High Very High Very High
Hemangiosarcoma 139 99.84 Very High Very High Very High
Cancer 133 99.76 Very High Very High Very High
Farber Lipogranulomatosis 30 98.76 Very High Very High Very High
Hematoma 22 98.64 Very High Very High Very High
Leukemia 7 97.48 Very High Very High Very High
Hodgkin's Disease 2 96.92 Very High Very High Very High
Osteogenic Sarcomas 4 96.04 Very High Very High Very High
Disease 26 94.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, while the AC-mRNA is expressed in all segments of the normal gastrointestinal tract, none of the gastrointestinal tumor tissues had any AC-mRNA expression.
Gene_expression (expressed) of AC-mRNA associated with cancer
1) Confidence 0.77 Published 2000 Journal Mol. Genet. Metab. Section Abstract Doc Link 10993717 Disease Relevance 0.78 Pain Relevance 0.06
Interestingly, while the AC-mRNA is expressed in all segments of the normal gastrointestinal tract, none of the gastrointestinal tumor tissues had any AC-mRNA expression.
Gene_expression (expression) of AC-mRNA associated with cancer
2) Confidence 0.77 Published 2000 Journal Mol. Genet. Metab. Section Abstract Doc Link 10993717 Disease Relevance 0.77 Pain Relevance 0.06
The AC-mRNA is expressed in the mouse fetus from the seventh day of gestation.
Gene_expression (expressed) of AC-mRNA
3) Confidence 0.77 Published 2000 Journal Mol. Genet. Metab. Section Abstract Doc Link 10993717 Disease Relevance 0.78 Pain Relevance 0.07
We also studied the AC-mRNA expression in gastrointestinal tumors and adjoining normal tissues.
Gene_expression (expression) of AC-mRNA associated with cancer
4) Confidence 0.60 Published 2000 Journal Mol. Genet. Metab. Section Abstract Doc Link 10993717 Disease Relevance 0.65 Pain Relevance 0.09
In addition, we determined the pattern of tissue-specific AC-mRNA expression in the adult mouse and during fetal development.
Gene_expression (expression) of AC-mRNA in adult mouse
5) Confidence 0.52 Published 2000 Journal Mol. Genet. Metab. Section Abstract Doc Link 10993717 Disease Relevance 0.71 Pain Relevance 0.08
Although there are interesting correlations between PHP and SHP, MND/ALS with aberrant calcium, vitamin D, and PTH metabolism, most of the literature does not indicate a conclusive relationship between ALS and PHP/SHP and treatment of PHP/SHP does not lead to improvement of MND.


Gene_expression (metabolism) of PHP associated with hypercalcemia and motor neuron diseases
6) Confidence 0.18 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2941760 Disease Relevance 2.32 Pain Relevance 0.07
Two additional proteins, putative 28 kDa protein and proline rich nuclear receptor coactivator-1 (PNRC1), were also identified as differentially expressed in both cell types.
Gene_expression (expressed) of putative 28 kDa protein
7) Confidence 0.15 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.48 Pain Relevance 0
The host may attempt to counter high cytokine levels by releasing soluble cytokine receptors (sCR) or by synthesizing high-affinity anti-cytokine antibodies (acAb), and these natural responses have spawned great interest as potential therapeutic approaches for alleviating cytokine-mediated disease.
Gene_expression (synthesizing) of acAb associated with disease and cytokine
8) Confidence 0.10 Published 2000 Journal J. Mol. Med. Section Abstract Doc Link 10794542 Disease Relevance 1.17 Pain Relevance 0.70
, and acid ceramidase, which also were more highly expressed in hemangiosarcomas than splenic hematomas.
Gene_expression (expressed) of acid ceramidase associated with hematoma and hemangiosarcoma
9) Confidence 0.03 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2994824 Disease Relevance 2.08 Pain Relevance 0.05

General Comments

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