INT8799

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Context Info
Confidence 0.58
First Reported 1992
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 24
Total Number 24
Disease Relevance 11.01
Pain Relevance 6.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Csrp1)
Anatomy Link Frequency
blood 1
joints 1
hip 1
pseudotumor 1
brachial artery 1
Csrp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 12 100.00 Very High Very High Very High
Pain 7 100.00 Very High Very High Very High
Angina 6 99.96 Very High Very High Very High
cINOD 15 99.84 Very High Very High Very High
cryotherapy 4 99.72 Very High Very High Very High
spinal inflammation 16 99.68 Very High Very High Very High
corticosteroid 4 99.68 Very High Very High Very High
Infliximab 10 99.02 Very High Very High Very High
Osteoarthritis 3 98.44 Very High Very High Very High
methotrexate 50 97.82 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 26 100.00 Very High Very High Very High
INFLAMMATION 19 100.00 Very High Very High Very High
Pain 5 100.00 Very High Very High Very High
Pressure Volume 2 Under Development 1 100.00 Very High Very High Very High
Angina 6 99.96 Very High Very High Very High
Rheumatoid Arthritis 68 99.92 Very High Very High Very High
Low Back Pain 18 99.68 Very High Very High Very High
Osteoarthritis 3 98.44 Very High Very High Very High
Osteomyelitis 4 96.24 Very High Very High Very High
Tachycardia 2 95.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The group of 16 patients treated, compared to a control group of 16 patients, has shown a significative decrease of CRP.
Negative_regulation (decrease) of CRP
1) Confidence 0.58 Published 1996 Journal Pediatr Med Chir Section Abstract Doc Link 9064671 Disease Relevance 0.49 Pain Relevance 0.25
In clinical studies serum CRP- und creatinine level declined in healthy subjects and patients with osteoarthritis under rose-hip treatment.
Negative_regulation (declined) of CRP in hip associated with osteoarthritis
2) Confidence 0.58 Published 2001 Journal Gesundheitswesen Section Abstract Doc Link 11467225 Disease Relevance 0.41 Pain Relevance 0.24
Conservative treatment should be limited to these cases, where we can see a quick recovery, reducing of the pain and decreasing of the level of CRP and ESR.
Negative_regulation (reducing) of CRP associated with pain
3) Confidence 0.58 Published 2002 Journal Chir Narzadow Ruchu Ortop Pol Section Abstract Doc Link 12087677 Disease Relevance 0.36 Pain Relevance 0.10
Regarding evolution of CRP and RF, a statistically significant reduction was observed only in positive RF.
Negative_regulation (reduction) of CRP
4) Confidence 0.43 Published 2000 Journal Medicina (B Aires) Section Abstract Doc Link 11188947 Disease Relevance 0.87 Pain Relevance 0.28
Patients in the surgically treated groups (groups A and B) showed a significant reduction in the number of swollen and painful joints and in their ESR and serum CRP levels, and this effect was maintained for at least 3 years.
Negative_regulation (reduction) of CRP in joints associated with pain
5) Confidence 0.42 Published 2000 Journal Int Orthop Section Abstract Doc Link 11153450 Disease Relevance 0.39 Pain Relevance 0.25
Conservative treatment should be limited to these cases, where we can see a quick recovery, reducing of the pain and decreasing of the level of CRP and ESR.
Negative_regulation (decreasing) of CRP associated with pain
6) Confidence 0.42 Published 2002 Journal Chir Narzadow Ruchu Ortop Pol Section Abstract Doc Link 12087677 Disease Relevance 0.36 Pain Relevance 0.10
The operating time, intraoperative blood loss, serum CRP and CK level, the duration of the indwelling chest tube, postoperative hospital stay, the duration of epidural anesthesia, complications and recurrences were compared among the three groups.
Negative_regulation (loss) of CRP in chest associated with anesthesia, pressure volume 2 under development, epidural and recurrence
7) Confidence 0.36 Published 1998 Journal Kyobu Geka Section Abstract Doc Link 9637842 Disease Relevance 0.42 Pain Relevance 0.34
Many studies have shown that serum CRP concentrations are not reduced by NSAIDs; however, one recent study has demonstrated that CRP concentration was reduced by the NSAIDs flurbiprofen and sustained-release ibuprofen in a subgroup of patients.
Neg (not) Negative_regulation (reduced) of CRP associated with cinod
8) Confidence 0.35 Published 1993 Journal Br. J. Rheumatol. Section Abstract Doc Link 7685225 Disease Relevance 0.63 Pain Relevance 0.36
Many studies have shown that serum CRP concentrations are not reduced by NSAIDs; however, one recent study has demonstrated that CRP concentration was reduced by the NSAIDs flurbiprofen and sustained-release ibuprofen in a subgroup of patients.
Negative_regulation (reduced) of CRP associated with cinod
9) Confidence 0.35 Published 1993 Journal Br. J. Rheumatol. Section Abstract Doc Link 7685225 Disease Relevance 0.61 Pain Relevance 0.36
The DMARDs such as gold salts, D-penicillamine, sulphasalazine and azathioprine have been shown to reduce serum CRP concentrations significantly in patients with RA.
Negative_regulation (reduce) of CRP associated with rheumatoid arthritis
10) Confidence 0.35 Published 1993 Journal Br. J. Rheumatol. Section Abstract Doc Link 7685225 Disease Relevance 0.68 Pain Relevance 0.30
CRP serum concentration is also reduced by the corticosteroids such as prednisone, but addition of pulse therapy with i.v. methylprednisolone had no additive effect compared with DMARDs alone.
Negative_regulation (reduced) of CRP associated with corticosteroid
11) Confidence 0.26 Published 1993 Journal Br. J. Rheumatol. Section Abstract Doc Link 7685225 Disease Relevance 0.67 Pain Relevance 0.32
Whole cell Na(+) current and channel protein expression were reduced in CRP-AM and CRP.
Negative_regulation (reduced) of CRP
12) Confidence 0.21 Published 2004 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 14693684 Disease Relevance 0.45 Pain Relevance 0.13
Whole cell Na(+) current and channel protein expression were reduced in CRP-AM and CRP.
Negative_regulation (reduced) of CRP
13) Confidence 0.21 Published 2004 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 14693684 Disease Relevance 0.45 Pain Relevance 0.13
Patients were included if they were (i) good responders (n = 147) (ESR <20 for >6/12 on stable dose of MTX) (ii) inefficacy failures (n = 101) (physician statement and failure to reduce ESR/CRP by 20%) or (iii) adverse event (AE) failures (n = 61) (verified by medical record review).
Negative_regulation (reduce) of CRP
14) Confidence 0.16 Published 2008 Journal Rheumatology (Oxford, England) Section Abstract Doc Link PMC2468887 Disease Relevance 0.32 Pain Relevance 0.08
The effects on laboratory indexes were a decrease in ESR and CRP in about 50% of the cases, an increase up to the normal value of hemoglobin in about 30% of the cases.
Negative_regulation (decrease) of CRP
15) Confidence 0.15 Published 1992 Journal Pediatr Med Chir Section Abstract Doc Link 1488307 Disease Relevance 0.15 Pain Relevance 0.35
Methotrexate (MTX) at a dose of 5mg/week was started in February 1991 and the pseudotumor decreased in size with a concurrent reduction of ESR, RF and CRP.
Negative_regulation (reduction) of CRP in pseudotumor associated with methotrexate
16) Confidence 0.12 Published 1992 Journal Ryumachi Section Abstract Doc Link 1440085 Disease Relevance 0.72 Pain Relevance 0.58
It controls chest pain, decreases CRP, and has favorable effects on brachial artery dilation variables in patients with coronary slow flow.
Negative_regulation (decreases) of CRP in brachial artery associated with angina
17) Confidence 0.05 Published 2009 Journal International heart journal Section Abstract Doc Link 19809204 Disease Relevance 0.36 Pain Relevance 0.27
The significant decrease of ESR and CRP in RA patients who became positive for ANA after treatment should be investigated in a larger number of patients.


Negative_regulation (decrease) of CRP
18) Confidence 0.05 Published 2006 Journal Reumatismo Section Body Doc Link 16829990 Disease Relevance 0 Pain Relevance 0
Taken together, Infliximab is an effective treatment for AS and results in decreased levels of the inflammation markers IL-6 and CRP, and of endogenous cortisol concentration.
Negative_regulation (decreased) of CRP associated with spinal inflammation, inflammation and infliximab
19) Confidence 0.04 Published 2007 Journal Rheumatol. Int. Section Abstract Doc Link 17242904 Disease Relevance 0.58 Pain Relevance 0.79
Elevated serum levels of IL-6, CRP and cortisol were reduced to normal levels by the 12 weeks time point.
Negative_regulation (reduced) of CRP
20) Confidence 0.04 Published 2007 Journal Rheumatol. Int. Section Abstract Doc Link 17242904 Disease Relevance 0.59 Pain Relevance 0.78

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