INT880

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Context Info
Confidence 0.70
First Reported 1975
Last Reported 2008
Negated 21
Speculated 12
Reported most in Abstract
Documents 304
Total Number 316
Disease Relevance 14.79
Pain Relevance 150.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gh1) signal transduction (Gh1) mitochondrion (Gh1)
extracellular space (Gh1) extracellular region (Gh1) plasma membrane (Gh1)
Anatomy Link Frequency
pituitary 28
hypothalamus 21
plasma 18
neurons 18
thyroid 14
Gh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 731 100.00 Very High Very High Very High
Clonidine 593 100.00 Very High Very High Very High
Morphine 275 100.00 Very High Very High Very High
Opioid 164 100.00 Very High Very High Very High
narcan 114 100.00 Very High Very High Very High
methadone 32 100.00 Very High Very High Very High
GABAergic 14 100.00 Very High Very High Very High
Somatostatin 635 99.98 Very High Very High Very High
opiate 143 99.98 Very High Very High Very High
opioid receptor 52 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypoglycemia 4 99.84 Very High Very High Very High
Hyperglycemia 12 99.68 Very High Very High Very High
Aging 26 99.62 Very High Very High Very High
Arthritis 10 99.48 Very High Very High Very High
Body Weight 86 99.26 Very High Very High Very High
Stress 1065 99.12 Very High Very High Very High
Obesity 110 98.76 Very High Very High Very High
Pressure Volume 2 Under Development 25 98.64 Very High Very High Very High
Starvation 220 98.52 Very High Very High Very High
INFLAMMATION 619 98.50 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These two changes resulted in a 3-fold increase in both mean GH concentration and total GH secretion over 6 h.
Positive_regulation (increase) of Localization (secretion) of GH
1) Confidence 0.70 Published 1993 Journal Life Sci. Section Abstract Doc Link 8385257 Disease Relevance 0 Pain Relevance 0.70
Clonidine microinjection into the amygdala nucleus had no effect on GH release, while the injection into the preoptic and anterior hypothalamic area (PO/AH) significantly stimulated GH release by causing it to begin 30 min earlier.
Positive_regulation (stimulated) of Localization (release) of GH in anterior associated with amygdala and clonidine
2) Confidence 0.69 Published 1983 Journal Endocrinol. Jpn. Section Abstract Doc Link 6141046 Disease Relevance 0.09 Pain Relevance 0.39
These findings suggest that the alpha 2-agonist acts on the PO/AH to induce an increase in GH release in alpha-methyl-p-tyrosine-pretreated rats, probably mediating the inhibitory input to somatostatinergic neurons which reside in the periventricular nucleus of the PO/AH area.
Positive_regulation (increase) of Localization (release) of GH in neurons associated with agonist
3) Confidence 0.69 Published 1983 Journal Endocrinol. Jpn. Section Abstract Doc Link 6141046 Disease Relevance 0.06 Pain Relevance 0.24
In the area from the posterior hypothalamus to the mammillary body, several injections stimulated GH release (6/15), but the stimulatory effect was statistically insignificant when comparison was made with the mean (+/- SE) for all 15 rats.
Positive_regulation (stimulated) of Localization (release) of GH in hypothalamus
4) Confidence 0.69 Published 1983 Journal Endocrinol. Jpn. Section Abstract Doc Link 6141046 Disease Relevance 0.07 Pain Relevance 0.34
Finally, the inability of clonidine to stimulate GH secretion and the absence of significant ultradian surges before day 35 suggest that the noradrenergic mechanism and possibly other neural systems which trigger the surges of GH secretion observed in adult rats do not mature until after puberty.
Positive_regulation (stimulate) of Localization (secretion) of GH in neural associated with clonidine
5) Confidence 0.69 Published 1981 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6970810 Disease Relevance 0 Pain Relevance 0.47
Apomorphine (0.5 mg/kg i.p.) had no effect on plasma GH levels, whereas clonidine (0.5 mg/kg i.p.) induced release of GH in both antiserum treated and control rats.
Positive_regulation (induced) of Localization (release) of GH in plasma associated with clonidine
6) Confidence 0.69 Published 1981 Journal Neuroendocrinology Section Abstract Doc Link 6114446 Disease Relevance 0 Pain Relevance 0.26
In view of the mechanisms by which MS and pentobarbital act to increase GH secretion, the present data suggest that the GH regulatory deficit observed in MSG-treated rats is due to a relative loss of GH-releasing factor secondary to ARC damage.
Positive_regulation (increase) of Localization (secretion) of GH associated with aids-related complex
7) Confidence 0.69 Published 1982 Journal Endocrinology Section Abstract Doc Link 6120072 Disease Relevance 0.29 Pain Relevance 0.14
These findings indicate that thyroid hormones are necessary to maintain both pulsatile and induced GH secretion in unanesthetized rats.
Positive_regulation (induced) of Localization (secretion) of GH in thyroid
8) Confidence 0.68 Published 1985 Journal Neuroendocrinology Section Abstract Doc Link 2867482 Disease Relevance 0.05 Pain Relevance 0.39
Treatment of TPTX rats with small doses of triiodothyronine (T3) restored an episodic pattern of GH secretion, but with lower peak values than controls, as well as the GH response to clonidine.
Positive_regulation (restored) of Localization (secretion) of GH associated with clonidine
9) Confidence 0.68 Published 1985 Journal Neuroendocrinology Section Abstract Doc Link 2867482 Disease Relevance 0.09 Pain Relevance 0.40
The relative importance of mu- and delta-receptors in stimulating GH secretion was also studied in older pups (day 20). i.c.v. administration of DAMGO stimulated GH secretion, while neither DPDPE nor deltorphin II consistently increased GH secretion.
Positive_regulation (stimulating) of Localization (secretion) of GH
10) Confidence 0.68 Published 1996 Journal Neuroendocrinology Section Abstract Doc Link 8793890 Disease Relevance 0 Pain Relevance 0.81
The relative importance of mu- and delta-receptors in stimulating GH secretion was also studied in older pups (day 20). i.c.v. administration of DAMGO stimulated GH secretion, while neither DPDPE nor deltorphin II consistently increased GH secretion.
Neg (neither) Positive_regulation (increased) of Neg (neither) Localization (secretion) of GH
11) Confidence 0.68 Published 1996 Journal Neuroendocrinology Section Abstract Doc Link 8793890 Disease Relevance 0 Pain Relevance 0.81
To ascertain the regeneration of hypophyseal portal vessels, post SRIH rebound in GH secretion, which requires the presence of endogenous GHRH, was examined.
Positive_regulation (requires) of Localization (secretion) of GH in vessels
12) Confidence 0.68 Published 1991 Journal Acta Endocrinol. Section Abstract Doc Link 1676866 Disease Relevance 0.13 Pain Relevance 0.13
These results suggest that clonidine stimulates rat GH secretion, possibly by acting within the hypothalamus to stimulate GH releasing factor neurons.
Spec (possibly) Positive_regulation (stimulates) of Localization (secretion) of GH in hypothalamus associated with clonidine
13) Confidence 0.68 Published 1984 Journal Neuroendocrinology Section Abstract Doc Link 6320028 Disease Relevance 0.25 Pain Relevance 0.56
In 30-day-old rats, pretreatment with yohimbine (2.5 mg/kg i.p.), but not prazosin (2.5 mg/kg s.c.) blocked opiate-induced GH release.
Positive_regulation (induced) of Localization (release) of GH associated with opiate
14) Confidence 0.68 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3007734 Disease Relevance 0 Pain Relevance 0.97
Catecholaminergic involvement in opiate-induced GH secretion was examined in 10-day-old and 30-day-old rats.
Spec (examined) Positive_regulation (induced) of Spec (examined) Localization (secretion) of GH associated with opiate
15) Confidence 0.68 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3007734 Disease Relevance 0 Pain Relevance 0.63
Both treatments blocked methadone-induced GH release in neonatal rats.
Positive_regulation (induced) of Localization (release) of GH associated with methadone
16) Confidence 0.68 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3007734 Disease Relevance 0 Pain Relevance 0.97
The role of noradrenergic neurons in opiate-induced GH secretion was examined by pretreating rats with diethyldithiocarbamate (400 mg/kg i.p.) or phenoxybenzamine (10 mg/kg i.p.).
Positive_regulation (induced) of Localization (secretion) of GH in neurons associated with opiate
17) Confidence 0.68 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3007734 Disease Relevance 0 Pain Relevance 0.90
Reserpine (1 mg/kg s.c.) abolished methadone-induced GH release in neonatal rats.
Positive_regulation (induced) of Localization (release) of GH associated with methadone
18) Confidence 0.68 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3007734 Disease Relevance 0 Pain Relevance 0.78
The inhibition of 5-HT synthesis by p-chlorophenylalanine also suppressed the secretory episode of GH seen in the morning and the release of GH induced by hypoglycaemia; both being partly restored in animals pretreated with 5-hydroxytryptamine.
Positive_regulation (induced) of Localization (release) of GH associated with hypoglycemia
19) Confidence 0.67 Published 1980 Journal J. Endocrinol. Section Abstract Doc Link 7430898 Disease Relevance 0.19 Pain Relevance 0.51
In 10-day-old rats, activation of alpha 2-adrenoceptors by clonidine (CLO) was effective to stimulate GH release starting from 50 micrograms/kg ip and up to 450 micrograms/kg ip, though no dose-related effect was evident.
Positive_regulation (stimulate) of Localization (release) of GH associated with clonidine
20) Confidence 0.67 Published 1987 Journal Endocrinology Section Abstract Doc Link 2881775 Disease Relevance 0 Pain Relevance 0.43

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