INT88005

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Context Info
Confidence 0.30
First Reported 2000
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 2.08
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MYOD1) nucleus (MYOD1) enzyme binding (MYOD1)
DNA binding (MYOD1) transcription factor binding (MYOD1) cytoplasm (MYOD1)
Anatomy Link Frequency
body 1
MYOD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 30 80.16 Quite High
tetrodotoxin 1 65.48 Quite High
Action potential 1 64.40 Quite High
Spinal cord 4 62.24 Quite High
deep brain stimulation 4 56.16 Quite High
imagery 1 10.28 Low Low
dexamethasone 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alveolar Rhabdomyosarcoma 3 99.64 Very High Very High Very High
Aging 1 98.04 Very High Very High Very High
Cancer 41 97.00 Very High Very High Very High
Reprotox - General 1 7 96.56 Very High Very High Very High
Bone Cancer 8 85.60 High High
Osteoporosis 12 81.08 Quite High
Pain 34 80.16 Quite High
Multiple Myeloma 1 76.20 Quite High
Deafness 4 72.24 Quite High
Parkinson's Disease 4 71.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been shown that ID proteins, by heterodimerization with bHLH proteins (MyoD, E12, E47), inhibit their binding to DNA, thus acting as dominant negative regulators, and have to be down-regulated to continue the differentiation process [44,45].
MyoD Neg (inhibit) Binding (heterodimerization) of
1) Confidence 0.30 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1829400 Disease Relevance 0.31 Pain Relevance 0
Collectively, the data suggest that the regulation of MHC isoform expression involves a complex interaction of multiple control mechanisms including the myogenin:MyoD and calcineurin:NF-AT pathways; however, other intracellular signaling pathways are likely to contribute.
MyoD Binding (interaction) of
2) Confidence 0.28 Published 2000 Journal Muscle Nerve Section Abstract Doc Link 10797389 Disease Relevance 0.11 Pain Relevance 0.18
These concerns and procedures – different as they may appear at first glance – point to the same important problem, namely the unclear or questionable relationships between the body, the self-determination of one and the same person, and its public articulation: What am I allowed to do with my own body, and to what extent can I permit others to do 'whatever they like' with their bodies?
self-determination Spec (unclear) Binding (point) of in body
3) Confidence 0.26 Published 2007 Journal Philos Ethics Humanit Med Section Body Doc Link PMC2180175 Disease Relevance 0.22 Pain Relevance 0.13
The role of care for bodily individuality and its characteristics, for the development of identity and thus for self-determination is further supported by the process of individualization and the deconstruction of fixed socially constructed categories such as 'healthy' and 'ill', 'ugly' and 'beautiful' or 'natural' and 'artificial'.
self-determination Binding (individuality) of
4) Confidence 0.26 Published 2007 Journal Philos Ethics Humanit Med Section Body Doc Link PMC2180175 Disease Relevance 0.14 Pain Relevance 0.03
But further interesting perspectives appear when bodily self-determination is complemented with concerns about the respect for the bodily unavailability of another person.
self-determination Binding (complemented) of
5) Confidence 0.26 Published 2007 Journal Philos Ethics Humanit Med Section Body Doc Link PMC2180175 Disease Relevance 0.13 Pain Relevance 0
However, as I argued above, this assumption could be self-contradictory if proponents of the liberal conception of self-determination recognize the principle of non-maleficience as a moral duty to act in a responsible way – as many scholars do.
self-determination Binding (recognize) of
6) Confidence 0.25 Published 2007 Journal Philos Ethics Humanit Med Section Body Doc Link PMC2180175 Disease Relevance 0.08 Pain Relevance 0.08
Alveolar rhabdomyosarcoma was ruled out by negative myogenin and myoD1 and by absence of PAX3/PAX7-FKHR translocations by FISH.
myoD1 Binding (negative) of associated with alveolar rhabdomyosarcoma
7) Confidence 0.10 Published 2010 Journal Mol Cytogenet Section Body Doc Link PMC2908072 Disease Relevance 1.09 Pain Relevance 0

General Comments

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