INT88007

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Context Info
Confidence 0.34
First Reported 2000
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.82
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GDNF) extracellular region (GDNF)
Anatomy Link Frequency
CSF 1
spinal cord 1
motoneurons 1
GDNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 6 97.48 Very High Very High Very High
Neuropathic pain 4 50.00 Quite Low
painful pain 2 50.00 Quite Low
Sciatica 2 25.00 Low Low
Pain 3 10.00 Low Low
Nerve growth factor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hydrocephalus 1 98.96 Very High Very High Very High
Motor Neuron Diseases 4 98.80 Very High Very High Very High
Nociception 2 98.28 Very High Very High Very High
Death 2 97.92 Very High Very High Very High
Frailty 4 97.76 Very High Very High Very High
Neuropathic Pain 4 96.36 Very High Very High Very High
Normal Pressure Hydrocephalus 1 50.00 Quite Low
Pain 2 5.00 Very Low Very Low Very Low
Syndrome 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Animals avulsed and treated with AxCAhGDNF showed intense immunolabeling for GDNF in lesioned spinal motoneurons and expression of virus-induced human GDNF mRNA transcripts in the lesioned spinal cord tissue.
Regulation (immunolabeling) of GDNF in spinal cord associated with spinal cord
1) Confidence 0.34 Published 2000 Journal J. Neurosci. Res. Section Abstract Doc Link 10797554 Disease Relevance 0.23 Pain Relevance 0.11
We examined neuroprotective effect of human GDNF encoded by an adenovirus vector (AxCAhGDNF) on the death of lesioned adult rat spinal motoneurons.
Spec (examined) Regulation (effect) of GDNF in motoneurons associated with death
2) Confidence 0.30 Published 2000 Journal J. Neurosci. Res. Section Abstract Doc Link 10797554 Disease Relevance 0.29 Pain Relevance 0.05
METHODS: The concentrations of GDNF, BDNF, CNTF, and NGF were analyzed in the lumbar CSF of 10 patients with chronic neuropathic pain, in 20 patients with lumbar back pain undergoing myelography, and in 10 patients with normal pressure hydrocephalus, by using enzymes-linked immunosorbent assay techniques.
Regulation (concentrations) of GDNF in CSF
3) Confidence 0.16 Published 2009 Journal Clin J Pain Section Body Doc Link 19920725 Disease Relevance 0.29 Pain Relevance 0

General Comments

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