INT88008

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Context Info
Confidence 0.70
First Reported 2000
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 8.90
Pain Relevance 3.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GDNF) extracellular region (GDNF)
Anatomy Link Frequency
glial cell 8
ventral roots 2
spinal cord 2
brain 2
lung 2
GDNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 12 99.64 Very High Very High Very High
antiallodynic 9 99.48 Very High Very High Very High
Neuropathic pain 15 99.40 Very High Very High Very High
Sciatica 8 99.06 Very High Very High Very High
dorsal root ganglion 3 98.64 Very High Very High Very High
Spinal cord 6 98.20 Very High Very High Very High
Morphine 1 97.44 Very High Very High Very High
Dorsal horn 3 97.20 Very High Very High Very High
addiction 1 97.08 Very High Very High Very High
Spinal nerve ligature 3 91.00 High High
Disease Link Frequency Relevance Heat
Lung Cancer 54 99.84 Very High Very High Very High
Cold Sores 12 99.80 Very High Very High Very High
Neuropathic Pain 15 99.40 Very High Very High Very High
Cancer 140 99.28 Very High Very High Very High
Ganglion Cysts 3 98.64 Very High Very High Very High
Neuroma 3 97.84 Very High Very High Very High
Pancreatic Cancer 30 97.76 Very High Very High Very High
Frailty 7 97.60 Very High Very High Very High
Metastasis 4 97.60 Very High Very High Very High
Morphine Dependence 1 97.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Vector-mediated GDNF expression blocked the nonnoxious touch-induced increase in c-fos expression in dorsal horn characteristic of the painful state.
Positive_regulation (mediated) of Gene_expression (expression) of GDNF in dorsal horn associated with pain and dorsal horn
1) Confidence 0.70 Published 2003 Journal Mol. Ther. Section Abstract Doc Link 12946309 Disease Relevance 0.92 Pain Relevance 0.93
Neuroregenerative effects of lentiviral vector-mediated GDNF expression in reimplanted ventral roots.
Positive_regulation (mediated) of Gene_expression (expression) of GDNF in ventral roots associated with sciatica
2) Confidence 0.66 Published 2008 Journal Mol. Cell. Neurosci. Section Title Doc Link 18585464 Disease Relevance 0.25 Pain Relevance 0.20
Here, we show in a rat model that lentiviral vector-mediated overexpression of glial cell line-derived neurotrophic factor (GDNF) in reimplanted nerve roots completely prevents motoneuron atrophy after ventral root avulsion and stimulates regeneration of axons into reimplanted roots.
Positive_regulation (overexpression) of Gene_expression (overexpression) of GDNF in glial cell associated with frailty
3) Confidence 0.57 Published 2008 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 18585464 Disease Relevance 0.27 Pain Relevance 0
These results indicate that the adenovirus-mediated gene transfer of GDNF may prevent the degeneration of motoneurons in adult humans with spinal cord injury and motor neuron diseases.
Positive_regulation (transfer) of Gene_expression (transfer) of GDNF in motoneurons associated with motor neuron diseases and spinal cord
4) Confidence 0.52 Published 2000 Journal J. Neurosci. Res. Section Abstract Doc Link 10797554 Disease Relevance 0.36 Pain Relevance 0.12
Intrapancreatic neural invasion by cancer cells was significantly related to over-expression of GDNF.
Positive_regulation (over-expression) of Gene_expression (over) of GDNF in neural associated with cancer
5) Confidence 0.50 Published 2008 Journal J. Int. Med. Res. Section Abstract Doc Link 18652760 Disease Relevance 0.92 Pain Relevance 0.09
We used immunohistochemical staining to assess protein over-expression of glial cell-derived neurotrophic factor (GDNF) and its RET receptor tyrosine kinase in patients with pancreatic cancer and benign pancreatic neoplasm, and assessed correlations with clinicopathological features and prognosis.
Positive_regulation (over-expression) of Gene_expression (expression) of GDNF in glial cell associated with pancreatic cancer
6) Confidence 0.50 Published 2008 Journal J. Int. Med. Res. Section Abstract Doc Link 18652760 Disease Relevance 0.54 Pain Relevance 0.05
We used immunohistochemical staining to assess protein over-expression of glial cell-derived neurotrophic factor (GDNF) and its RET receptor tyrosine kinase in patients with pancreatic cancer and benign pancreatic neoplasm, and assessed correlations with clinicopathological features and prognosis.
Positive_regulation (over-expression) of Gene_expression (expression) of glial cell-derived neurotrophic factor in glial cell associated with pancreatic cancer
7) Confidence 0.50 Published 2008 Journal J. Int. Med. Res. Section Abstract Doc Link 18652760 Disease Relevance 0.54 Pain Relevance 0.05
To examine whether HSV-mediated expression of GDNF could be used to ameliorate neuropathic pain, we constructed a replication-incompetent HSV vector expressing GDNF.
Positive_regulation (used) of Gene_expression (expression) of GDNF associated with cold sores and neuropathic pain
8) Confidence 0.50 Published 2003 Journal Mol. Ther. Section Abstract Doc Link 12946309 Disease Relevance 1.08 Pain Relevance 0.86
We have demonstrated that systemic administration of dipeptide Leu-Ile increases BDNF and GDNF production in the brain, and has a protective role in methamphetamine and morphine dependence.
Positive_regulation (increases) of Gene_expression (production) of GDNF in brain associated with addiction and morphine
9) Confidence 0.49 Published 2009 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 19562947 Disease Relevance 0.49 Pain Relevance 0.18
GDNF has been reported to be overexpressed in lung tumor tissue [53] and is silent in normal adult lung [54].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of GDNF in lung associated with lung cancer
10) Confidence 0.48 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2483990 Disease Relevance 1.11 Pain Relevance 0
Strongly positive expression of GDNF may be an indication for early intensified radiotherapy.
Positive_regulation (positive) of Gene_expression (expression) of GDNF
11) Confidence 0.47 Published 2008 Journal J. Int. Med. Res. Section Abstract Doc Link 18652760 Disease Relevance 0.90 Pain Relevance 0.09
However, over the course of 16 weeks neuroma-like structures are formed in the reimplanted roots, and regenerating axons are trapped at sites with high levels of GDNF expression.
Positive_regulation (levels) of Gene_expression (expression) of GDNF associated with neuroma
12) Confidence 0.44 Published 2008 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 18585464 Disease Relevance 0.26 Pain Relevance 0
HSV-mediated gene transfer of the glial cell-derived neurotrophic factor provides an antiallodynic effect on neuropathic pain.
Positive_regulation (transfer) of Gene_expression (transfer) of cell-derived neurotrophic factor in glial cell associated with pain, neuropathic pain and antiallodynic
13) Confidence 0.41 Published 2003 Journal Mol. Ther. Section Title Doc Link 12946309 Disease Relevance 1.02 Pain Relevance 0.94
Animals avulsed and treated with AxCAhGDNF showed intense immunolabeling for GDNF in lesioned spinal motoneurons and expression of virus-induced human GDNF mRNA transcripts in the lesioned spinal cord tissue.
Positive_regulation (induced) of Gene_expression (expression) of GDNF in spinal cord associated with spinal cord
14) Confidence 0.35 Published 2000 Journal J. Neurosci. Res. Section Abstract Doc Link 10797554 Disease Relevance 0.23 Pain Relevance 0.11

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