INT88014

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Context Info
Confidence 0.50
First Reported 2000
Last Reported 2009
Negated 4
Speculated 1
Reported most in Body
Documents 29
Total Number 30
Disease Relevance 14.84
Pain Relevance 7.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fas) aging (Fas) extracellular region (Fas)
plasma membrane (Fas) nucleus (Fas) cytoplasm (Fas)
Anatomy Link Frequency
T cells 6
brain 4
lymphocytes 4
astrocytes 4
DBTRG-05MG 4
Fas (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 3 100.00 Very High Very High Very High
Hippocampus 9 99.80 Very High Very High Very High
withdrawal 24 99.58 Very High Very High Very High
Morphine 16 99.16 Very High Very High Very High
cytokine 11 99.16 Very High Very High Very High
Neuritis 3 99.04 Very High Very High Very High
chemokine 1 98.64 Very High Very High Very High
agonist 19 98.36 Very High Very High Very High
Inflammation 14 97.88 Very High Very High Very High
opiate 20 97.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Brain Tumor 47 100.00 Very High Very High Very High
Malignant Neoplastic Disease 31 100.00 Very High Very High Very High
Pancreatitis 3 100.00 Very High Very High Very High
Convulsion 9 99.98 Very High Very High Very High
Gastritis 8 99.98 Very High Very High Very High
Basal Cell Carcinoma 8 99.84 Very High Very High Very High
Apoptosis 900 99.68 Very High Very High Very High
Opiate Addiction 16 99.58 Very High Very High Very High
Sepsis 49 99.48 Very High Very High Very High
Injury 103 99.34 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The main results indicate that chronic heroin/morphine treatment and heroin withdrawal are associated with up-regulation of 35 kDa native Fas (and with different expressions of glycosylated Fas), and also with concomitant increases of dynamin in rat brain.
Positive_regulation (up-regulation) of Gene_expression (expressions) of Fas in brain associated with opiate addiction, withdrawal and morphine
1) Confidence 0.50 Published 2003 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 14530904 Disease Relevance 0.27 Pain Relevance 1.22
Chronic (5 days) heroin (5-30 mg/kg) and morphine (10-100 mg/kg) were also associated with increased native Fas (76% and 45%) and with different expressions of glycosylated Fas.
Positive_regulation (increased) of Gene_expression (expressions) of Fas associated with morphine
2) Confidence 0.50 Published 2003 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 14530904 Disease Relevance 0.30 Pain Relevance 1.13
Chronic (5 days) heroin (5-30 mg/kg) and morphine (10-100 mg/kg) were also associated with increased native Fas (76% and 45%) and with different expressions of glycosylated Fas.
Positive_regulation (increased) of Gene_expression (expressions) of Fas associated with morphine
3) Confidence 0.50 Published 2003 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 14530904 Disease Relevance 0.30 Pain Relevance 1.09
The main results indicate that chronic heroin/morphine treatment and heroin withdrawal are associated with up-regulation of 35 kDa native Fas (and with different expressions of glycosylated Fas), and also with concomitant increases of dynamin in rat brain.
Positive_regulation (up-regulation) of Gene_expression (expressions) of Fas in brain associated with opiate addiction, withdrawal and morphine
4) Confidence 0.50 Published 2003 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 14530904 Disease Relevance 0.27 Pain Relevance 1.22
However, whether Fas and FasL are expressed in chronic pancreatitis is unknown.
Positive_regulation (pancreatitis) of Gene_expression (expressed) of Fas associated with chronic pancreatitis
5) Confidence 0.48 Published 2001 Journal Dig. Dis. Sci. Section Abstract Doc Link 11270781 Disease Relevance 0.70 Pain Relevance 0.24
We suggest that Fas/FasL expression on SC may contribute to the elimination of invading autoreactive T cells in the PNS in concert with other immune defense mechanisms.
Spec (may) Positive_regulation (contribute) of Gene_expression (expression) of Fas in T cells
6) Confidence 0.46 Published 2000 Journal Glia Section Abstract Doc Link 10797617 Disease Relevance 0.46 Pain Relevance 0.19
These findings are in accord with recently published results showing Fas and FasL expression on malignant human cells, derived from brain tumors and upregulation of FasL on astrocytes after exposure to IFN-gamma and TNF-alpha.
Positive_regulation (upregulation) of Gene_expression (expression) of Fas in astrocytes associated with malignant neoplastic disease and brain tumor
7) Confidence 0.46 Published 2000 Journal Glia Section Abstract Doc Link 10797617 Disease Relevance 0.74 Pain Relevance 0.23
These findings are in accord with recently published results showing Fas and FasL expression on malignant human cells, derived from brain tumors and upregulation of FasL on astrocytes after exposure to IFN-gamma and TNF-alpha.
Positive_regulation (showing) of Gene_expression (expression) of Fas in astrocytes associated with malignant neoplastic disease and brain tumor
8) Confidence 0.46 Published 2000 Journal Glia Section Abstract Doc Link 10797617 Disease Relevance 0.74 Pain Relevance 0.22
In the adult rat hippocampus, seizure leads to the co-localized expression of p53 and Fas in CA1 neurons [36].
Positive_regulation (leads) of Gene_expression (expression) of Fas in neurons associated with convulsion and hippocampus
9) Confidence 0.40 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.92 Pain Relevance 0.08
Since activated T cells express elevated level of Fas, we then determined the cytotoxicity of KC against alloreactive T cells (ATC).
Positive_regulation (elevated) of Gene_expression (express) of Fas in T cells
10) Confidence 0.32 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2410251 Disease Relevance 0.05 Pain Relevance 0
Our previous western immunoblot analyses indicated that in control CHB50 cortical cultures, Fas expression was statistically significantly induced 72 hours following p53 activation (Figure 5B,5C).
Positive_regulation (induced) of Gene_expression (expression) of Fas
11) Confidence 0.29 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.15 Pain Relevance 0.09
One issue that remains to be addressed is whether estrogen suppresses cell-surface Fas expression by acting as a non-classical transcription repressor, or by suppressing translocation of Fas from intracellular compartments to the cell-surface in a manner that is antagonistic to that observed for p53 [34].
Positive_regulation (surface) of Gene_expression (expression) of Fas
12) Confidence 0.29 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.27 Pain Relevance 0.04
Our results showed that loss of contact with the collagen matrix resulted in a significant increase in Fas expression, and was associated with the phenomenon of 'anoikis'.
Positive_regulation (increase) of Gene_expression (expression) of Fas
13) Confidence 0.29 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.32 Pain Relevance 0.04
Since increased AICD with thermal injury/sepsis could also be related to increased expressions of receptors Fas and TNFR, their surface expressions was assessed using anti-Fas and anti-TNFR antibodies and FACS analyses.
Positive_regulation (increased) of Gene_expression (expressions) of Fas associated with injury, sepsis and death
14) Confidence 0.27 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1989035 Disease Relevance 1.56 Pain Relevance 0.07
Activation of the transcription factor p53 was associated with induction of Fas expression, while the gonadal hormone estrogen antagonistically suppressed cell-surface Fas expression.
Positive_regulation (induction) of Gene_expression (expression) of Fas in gonadal
15) Confidence 0.27 Published 2004 Journal BMC Neurosci Section Abstract Doc Link PMC395829 Disease Relevance 0.66 Pain Relevance 0.03
Fas expression is dependent on cell-matrix interactions and 'anoikis'
Positive_regulation (dependent) of Gene_expression (expression) of Fas
16) Confidence 0.27 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.65 Pain Relevance 0.07
We therefore examined the extent to which cell-surface Fas expression was estrogen-dependent.
Positive_regulation (dependent) of Gene_expression (expression) of Fas
17) Confidence 0.27 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.18 Pain Relevance 0
In contrast, flow cytometric analyses of non-permeabilized cultured embryonic cortical-derived neuronal precursors (Figure 2) indicate that 23–28% of these cells expressed Fas on their cell surface in vitro, representing ~2-fold induction of cell surface Fas expression in vitro, as compared to in vivo.
Positive_regulation (induction) of Gene_expression (expression) of Fas in neuronal precursors
18) Confidence 0.27 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.22 Pain Relevance 0
Since Fas expression was positively associated with p53 phosphorylation, it is likely that estrogen protection against apoptosis is contextual, i.e., dependent on the activation of p53.
Positive_regulation (associated) of Gene_expression (expression) of Fas associated with apoptosis
19) Confidence 0.27 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.36 Pain Relevance 0.04
Since activated T cells express elevated level of Fas, we then determined the cytotoxicity of KC against alloreactive T cells (ATC).
Positive_regulation (activated) of Gene_expression (express) of Fas in T cells
20) Confidence 0.23 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2410251 Disease Relevance 0.05 Pain Relevance 0

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