INT88015

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Context Info
Confidence 0.65
First Reported 2000
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 5.73
Pain Relevance 1.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Faslg) extracellular space (Faslg) extracellular region (Faslg)
cytoplasmic membrane-bounded vesicle (Faslg) plasma membrane (Faslg)
Anatomy Link Frequency
endothelium 1
astrocytes 1
T cells 1
Faslg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 4 96.88 Very High Very High Very High
Inflammation 17 96.44 Very High Very High Very High
Sciatic nerve 2 89.68 High High
Angina 1 87.52 High High
cytokine 12 85.88 High High
Neuritis 2 84.16 Quite High
Pain 6 82.80 Quite High
anesthesia 2 79.84 Quite High
agonist 1 72.16 Quite High
Etanercept 26 56.32 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 64 100.00 Very High Very High Very High
Brain Tumor 2 99.90 Very High Very High Very High
Adhesions 10 99.14 Very High Very High Very High
Malignant Neoplastic Disease 2 99.12 Very High Very High Very High
Cancer 7 98.68 Very High Very High Very High
Necrosis 7 98.44 Very High Very High Very High
INFLAMMATION 19 96.44 Very High Very High Very High
Death 32 94.88 High High
Diabetes Mellitus 71 94.52 High High
Injury 13 90.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings are in accord with recently published results showing Fas and FasL expression on malignant human cells, derived from brain tumors and upregulation of FasL on astrocytes after exposure to IFN-gamma and TNF-alpha.
Positive_regulation (upregulation) of FasL in astrocytes associated with malignant neoplastic disease and brain tumor
1) Confidence 0.65 Published 2000 Journal Glia Section Abstract Doc Link 10797617 Disease Relevance 0.72 Pain Relevance 0.23
For example, the mRNAs for TNF-R1, FasL, and Nur77 are up-regulated between 2.8 and 7-fold [Mol.
Positive_regulation (up-regulated) of FasL
2) Confidence 0.55 Published 2002 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12531535 Disease Relevance 0.17 Pain Relevance 0.08
QUIS injections also resulted in an increase in mRNA levels of interleukin-1 beta (IL-1 beta), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), CD95 ligand (CD95-L, also called FAS-L/APO-1L), and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).
Positive_regulation (increase) of CD95-L associated with necrosis, cancer and apoptosis
3) Confidence 0.23 Published 2001 Journal Exp. Neurol. Section Abstract Doc Link 11170729 Disease Relevance 1.79 Pain Relevance 0.78
In addition, the converse upregulation of adhesion molecules and Fas on the endothelium, and increases in FasL on the leukocytes, could function together to drive the balance toward a significantly increased leukocyte-induced endothelial death in diabetes.
Positive_regulation (increases) of FasL in endothelium associated with diabetes mellitus, death and adhesions
4) Confidence 0.22 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2716944 Disease Relevance 1.42 Pain Relevance 0.07
In analogy with other immune-protected sites, participation of the apoptosis-inducing Fas/FasL molecules could play an important role.
Positive_regulation (apoptosis-inducing) of FasL associated with apoptosis
5) Confidence 0.21 Published 2000 Journal Glia Section Abstract Doc Link 10797617 Disease Relevance 0.63 Pain Relevance 0.09
We also investigated Fas expression on T cells (evaluated by flow cytometry) and FasL mRNA (evaluated by RT-PCR), as well as Fas functionality.
Spec (investigated) Positive_regulation (investigated) of FasL in T cells
6) Confidence 0.06 Published 2003 Journal Clin. Exp. Med. Section Abstract Doc Link 12748878 Disease Relevance 1.00 Pain Relevance 0.19

General Comments

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