INT88016

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Context Info
Confidence 0.54
First Reported 2000
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.18
Pain Relevance 1.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Faslg) extracellular space (Faslg) extracellular region (Faslg)
cytoplasmic membrane-bounded vesicle (Faslg) plasma membrane (Faslg)
Anatomy Link Frequency
acinar cell 2
Faslg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 14 100.00 Very High Very High Very High
cytokine 1 99.04 Very High Very High Very High
antagonist 1 80.84 Quite High
opiate 2 80.04 Quite High
cINOD 2 76.20 Quite High
Inflammation 5 75.72 Quite High
tolerance 9 72.88 Quite High
Sciatic nerve 1 57.28 Quite High
Neuritis 1 51.76 Quite High
Chronic pancreatitis 3 50.00 Quite Low
Disease Link Frequency Relevance Heat
Death 4 99.92 Very High Very High Very High
Apoptosis 20 99.08 Very High Very High Very High
Shock 1 92.84 High High
Necrosis 1 89.28 High High
Cancer 1 88.92 High High
INFLAMMATION 5 75.72 Quite High
Malignant Neoplastic Disease 1 73.44 Quite High
Injury 1 73.04 Quite High
Brain Tumor 1 70.56 Quite High
Ulcers 1 62.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, in the TJ-10-treated rats, the rate of pancreatic acinar cell destruction, the apoptotic index at 12-20 weeks, and the expression of Fas and FasL at 12 and 20 weeks decreased significantly compared to those in untreated rats.
Negative_regulation (decreased) of Gene_expression (expression) of FasL in acinar cell
1) Confidence 0.54 Published 2007 Journal Pancreatology Section Body Doc Link 17449963 Disease Relevance 0.06 Pain Relevance 0
Whether a genetic difference in KC FasL expression contributes to allograft acceptance in this model remains to be elucidated.
Spec (Whether) Negative_regulation (difference) of Gene_expression (expression) of FasL
2) Confidence 0.41 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2410251 Disease Relevance 0.20 Pain Relevance 0.16
IFN-gamma and TNF-alpha acted synergistically, leading to an increased FasL expression that reached its maximum 70 h after cytokine exposure, as shown by FACS analysis, SDS-PAGE, and Western blot.
Negative_regulation (reached) of Gene_expression (expression) of FasL associated with cytokine
3) Confidence 0.40 Published 2000 Journal Glia Section Abstract Doc Link 10797617 Disease Relevance 0.75 Pain Relevance 0.20
Moreover, naltrexone inhibited morphine-induced FasL expression.
Negative_regulation (inhibited) of Gene_expression (expression) of FasL associated with morphine
4) Confidence 0.10 Published 2002 Journal J. Immunol. Section Abstract Doc Link 11937560 Disease Relevance 0.48 Pain Relevance 1.34
Lansoprazole also inhibits indomethacin-induced Fas-mediated mucosal cell death by down-regulating Fas or FasL expression and inhibiting caspase-8 activation.
Negative_regulation (down-regulating) of Gene_expression (expression) of FasL associated with death
5) Confidence 0.07 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18375387 Disease Relevance 0.69 Pain Relevance 0.23

General Comments

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