INT88017

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Context Info
Confidence 0.62
First Reported 2000
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 12
Total Number 14
Disease Relevance 8.27
Pain Relevance 2.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fas) aging (Fas) extracellular region (Fas)
plasma membrane (Fas) nucleus (Fas) cytoplasm (Fas)
Anatomy Link Frequency
brain 2
neuroblasts 1
proximal 1
apoptotic cell 1
upper 1
Fas (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fortral 4 100.00 Very High Very High Very High
Glutamate 145 99.28 Very High Very High Very High
opiate 5 98.48 Very High Very High Very High
addiction 2 98.20 Very High Very High Very High
withdrawal 5 96.84 Very High Very High Very High
antagonist 21 96.44 Very High Very High Very High
Inflammation 6 96.20 Very High Very High Very High
cytokine 5 94.64 High High
Hippocampus 9 93.08 High High
Chronic pancreatitis 6 92.40 High High
Disease Link Frequency Relevance Heat
Suicidal Behaviour 162 99.96 Very High Very High Very High
Neurodegenerative Disease 54 99.30 Very High Very High Very High
Apoptosis 561 99.20 Very High Very High Very High
Cancer 107 98.72 Very High Very High Very High
Opiate Addiction 4 98.48 Very High Very High Very High
Death 173 96.72 Very High Very High Very High
INFLAMMATION 6 96.20 Very High Very High Very High
Disease 18 94.68 High High
Convulsion 6 93.44 High High
Pancreatitis 6 92.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Modulation of Fas receptor proteins and dynamin during opiate addiction and induction of opiate withdrawal in rat brain.
Regulation (Modulation) of Fas in brain associated with fortral, addiction, opiate and withdrawal
1) Confidence 0.62 Published 2003 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 14530904 Disease Relevance 0.37 Pain Relevance 1.04
Apoptosis in rat spontaneous chronic pancreatis: role of the Fas and Fas ligand system.
Regulation (role) of Fas associated with apoptosis
2) Confidence 0.43 Published 2001 Journal Dig. Dis. Sci. Section Title Doc Link 11270781 Disease Relevance 0.77 Pain Relevance 0.23
Apoptosis in rat spontaneous chronic pancreatis: role of the Fas and Fas ligand system.
Regulation (role) of Fas associated with apoptosis
3) Confidence 0.43 Published 2001 Journal Dig. Dis. Sci. Section Title Doc Link 11270781 Disease Relevance 0.77 Pain Relevance 0.23
Regulation of Fas and FasL expression on rat Schwann cells.
Regulation (Regulation) of Fas in Schwann cells
4) Confidence 0.41 Published 2000 Journal Glia Section Title Doc Link 10797617 Disease Relevance 0.58 Pain Relevance 0.12
We also hypothesized that estrogen controls neurogenesis and neuron elimination, either by regulating the Fas receptor, or by regulating specific anti-apoptotic cell cycle elements in a Fas-dependent manner.
Regulation (regulating) of Fas in apoptotic cell associated with apoptosis and neurodegenerative disease
5) Confidence 0.35 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.43 Pain Relevance 0.08
FAS, a critical enzyme required for fatty acid de novo synthesis, showed an increased activity in rats feed OA diet.
Regulation (required) of FAS
6) Confidence 0.35 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2846940 Disease Relevance 1.20 Pain Relevance 0
However, in primary cortical cells, we did not observe any change in Fas receptor protein levels following glutamate treatment.
Regulation (change) of Fas receptor protein associated with glutamate
7) Confidence 0.30 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC555946 Disease Relevance 1.17 Pain Relevance 0.32
Estrogen and Fas regulation of the cell cycle-associated proteins
Regulation (regulation) of Fas
8) Confidence 0.26 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.27 Pain Relevance 0.09
However, it is likely that p53 acts in concert with a coterie of transcription factors to regulate the availability of Fas in the developing brain.
Regulation (regulate) of Fas in brain
9) Confidence 0.26 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.81 Pain Relevance 0.08
Hence there was an up-regulation of pathways such as nfkb, rela, tnfr2 and tob1 while there was a down-regulation of FAS.
Regulation (regulation) of FAS
10) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607546 Disease Relevance 0.06 Pain Relevance 0.08
Estrogen and Fas regulation of other cell cycle-related proteins
Regulation (regulation) of Fas
11) Confidence 0.16 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.25 Pain Relevance 0
CHB50 cortical neuroblasts were therefore cultured under the +tsTA and -tsTA conditions as published previously [37] to examine the p53-related expression of Fas, and under the -tsTA conditions to examine the estrogen regulation of Fas during neuroblast differentiation (in the context of p53 activation).


Spec (examine) Regulation (regulation) of Fas in neuroblasts
12) Confidence 0.16 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.26 Pain Relevance 0
Competing intrinsic (p53, cell cycle, FLIP expression), proximal (extra-cellular matrix) and extrinsic factors (gonadal hormones) collectively regulate Fas suicide-sensitivity either during neurogenesis, or possibly during neuronal migration, and may ultimately determine which neuroblasts successfully contribute neurons to the differentiating cortical plate.



Spec (possibly) Regulation (regulate) of Fas in proximal associated with suicidal behaviour and neurodegenerative disease
13) Confidence 0.16 Published 2004 Journal BMC Neurosci Section Abstract Doc Link PMC395829 Disease Relevance 0.57 Pain Relevance 0
The upper regulation of Fas and Bax protein was an association phenomenon.
Regulation (regulation) of Fas in upper
14) Confidence 0.08 Published 2006 Journal Journal of Neurochemistry Section Body Doc Link PMC1804119 Disease Relevance 0.77 Pain Relevance 0.03

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