INT88019

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Context Info
Confidence 0.67
First Reported 2000
Last Reported 2009
Negated 0
Speculated 2
Reported most in Abstract
Documents 16
Total Number 18
Disease Relevance 11.31
Pain Relevance 5.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Faslg) extracellular space (Faslg) extracellular region (Faslg)
cytoplasmic membrane-bounded vesicle (Faslg) plasma membrane (Faslg)
Anatomy Link Frequency
liver 4
astrocytes 4
T cells 4
macrophage 2
leukocytes 2
Faslg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 4 100.00 Very High Very High Very High
Morphine 30 99.98 Very High Very High Very High
Neuritis 6 98.88 Very High Very High Very High
cytokine 15 98.52 Very High Very High Very High
Inflammation 24 97.56 Very High Very High Very High
Sciatic nerve 6 96.32 Very High Very High Very High
tolerance 45 92.00 High High
Angina 1 87.52 High High
antagonist 3 86.84 High High
opiate 4 86.04 High High
Disease Link Frequency Relevance Heat
Brain Tumor 6 100.00 Very High Very High Very High
Malignant Neoplastic Disease 6 100.00 Very High Very High Very High
Pancreatitis 4 100.00 Very High Very High Very High
Primary Sclerosing Cholangitis 8 99.16 Very High Very High Very High
Disease 1 98.92 Very High Very High Very High
Experimental Autoimmune Neuritis 6 98.88 Very High Very High Very High
Apoptosis 142 98.32 Very High Very High Very High
Diabetes Mellitus 71 98.20 Very High Very High Very High
INFLAMMATION 26 97.56 Very High Very High Very High
Necrosis 11 97.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, FasL expression is higher in DA rat KC than in Lewis rat KC.
Positive_regulation (higher) of Gene_expression (expression) of FasL
1) Confidence 0.67 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2410251 Disease Relevance 0.20 Pain Relevance 0.15
KC FasL expression is increased following liver transplantation and associated with increased ability of KC lyses ATC.
Positive_regulation (increased) of Gene_expression (expression) of FasL in liver
2) Confidence 0.67 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2410251 Disease Relevance 0.23 Pain Relevance 0.07
We observed upregulation of FasL expression under the influence of IFN-gamma, while adding TNF-alpha alone to the culture medium had no effect.
Positive_regulation (upregulation) of Gene_expression (expression) of FasL
3) Confidence 0.65 Published 2000 Journal Glia Section Abstract Doc Link 10797617 Disease Relevance 0.72 Pain Relevance 0.12
IFN-gamma and TNF-alpha acted synergistically, leading to an increased FasL expression that reached its maximum 70 h after cytokine exposure, as shown by FACS analysis, SDS-PAGE, and Western blot.
Positive_regulation (leading) of Gene_expression (expression) of FasL associated with cytokine
4) Confidence 0.65 Published 2000 Journal Glia Section Abstract Doc Link 10797617 Disease Relevance 0.75 Pain Relevance 0.20
Donor Lewis hepatic KC replacement by recipient DA KC following liver transplantation results in increased FasL expression by KC in the liver allografts.
Positive_regulation (increased) of Gene_expression (expression) of FasL in liver
5) Confidence 0.49 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2410251 Disease Relevance 0.20 Pain Relevance 0.16
IFN-gamma induced overexpression of FasL in KC has been proposed as a mechanism of hepatic immunoregulation [17].
Positive_regulation (induced) of Gene_expression (overexpression) of FasL
6) Confidence 0.49 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2410251 Disease Relevance 0.21 Pain Relevance 0.16
IFN-gamma induced overexpression of FasL in KC has been proposed as a mechanism of hepatic immunoregulation [17].
Positive_regulation (overexpression) of Gene_expression (overexpression) of FasL
7) Confidence 0.49 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2410251 Disease Relevance 0.21 Pain Relevance 0.16
However, whether Fas and FasL are expressed in chronic pancreatitis is unknown.
Positive_regulation (pancreatitis) of Gene_expression (expressed) of FasL associated with chronic pancreatitis
8) Confidence 0.48 Published 2001 Journal Dig. Dis. Sci. Section Abstract Doc Link 11270781 Disease Relevance 0.70 Pain Relevance 0.24
These findings are in accord with recently published results showing Fas and FasL expression on malignant human cells, derived from brain tumors and upregulation of FasL on astrocytes after exposure to IFN-gamma and TNF-alpha.
Positive_regulation (upregulation) of Gene_expression (expression) of FasL in astrocytes associated with malignant neoplastic disease and brain tumor
9) Confidence 0.47 Published 2000 Journal Glia Section Abstract Doc Link 10797617 Disease Relevance 0.74 Pain Relevance 0.23
We suggest that Fas/FasL expression on SC may contribute to the elimination of invading autoreactive T cells in the PNS in concert with other immune defense mechanisms.
Spec (may) Positive_regulation (contribute) of Gene_expression (expression) of FasL in T cells
10) Confidence 0.47 Published 2000 Journal Glia Section Abstract Doc Link 10797617 Disease Relevance 0.46 Pain Relevance 0.18
These findings are in accord with recently published results showing Fas and FasL expression on malignant human cells, derived from brain tumors and upregulation of FasL on astrocytes after exposure to IFN-gamma and TNF-alpha.
Positive_regulation (showing) of Gene_expression (expression) of FasL in astrocytes associated with malignant neoplastic disease and brain tumor
11) Confidence 0.47 Published 2000 Journal Glia Section Abstract Doc Link 10797617 Disease Relevance 0.74 Pain Relevance 0.22
IFN-gamma and TNF-alpha acted synergistically, leading to an increased FasL expression that reached its maximum 70 h after cytokine exposure, as shown by FACS analysis, SDS-PAGE, and Western blot.
Positive_regulation (increased) of Gene_expression (expression) of FasL associated with cytokine
12) Confidence 0.43 Published 2000 Journal Glia Section Abstract Doc Link 10797617 Disease Relevance 0.75 Pain Relevance 0.20
CONCLUSION: EA at "Zusanli" (ST 36) can inhibit morphine-induced downregulation of Bcl-2 and upregulation of Fas and FasL expression, which may contribute to its effect in resisting thymus apoptosis in morphine withdrawal rats.


Positive_regulation (upregulation) of Gene_expression (expression) of FasL in thymus
13) Confidence 0.32 Published 2008 Journal Zhen Ci Yan Jiu Section Body Doc Link 18928115 Disease Relevance 0 Pain Relevance 0
B that in turn upregulates FasL expression in leukocytes [39].
Positive_regulation (upregulates) of Gene_expression (expression) of FasL in leukocytes
14) Confidence 0.31 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2716944 Disease Relevance 1.75 Pain Relevance 0.08
Sensitization of PSC with culture duration was accompanied by increased expression of CD95 and TRAIL receptor 2 and no alterations of Flip expression or protein kinase B phosphorylation but was paralleled by the appearance of a COOH-terminal cleavage product of receptor-interacting protein.
Positive_regulation (increased) of Gene_expression (expression) of CD95 in cleavage associated with primary sclerosing cholangitis
15) Confidence 0.30 Published 2002 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 12181199 Disease Relevance 1.72 Pain Relevance 0.07
Moreover, naltrexone inhibited morphine-induced FasL expression.
Positive_regulation (induced) of Gene_expression (expression) of FasL associated with morphine
16) Confidence 0.12 Published 2002 Journal J. Immunol. Section Abstract Doc Link 11937560 Disease Relevance 0.48 Pain Relevance 1.34
Morphine also enhanced the expression of both Fas and Fas ligand (FasL), whereas anti-FasL Ab prevented morphine-induced macrophage apoptosis.
Positive_regulation (enhanced) of Gene_expression (expression) of FasL in macrophage associated with apoptosis and morphine
17) Confidence 0.09 Published 2002 Journal J. Immunol. Section Abstract Doc Link 11937560 Disease Relevance 0.45 Pain Relevance 1.27
We also investigated Fas expression on T cells (evaluated by flow cytometry) and FasL mRNA (evaluated by RT-PCR), as well as Fas functionality.
Spec (investigated) Positive_regulation (investigated) of Spec (investigated) Gene_expression (expression) of FasL in T cells
18) Confidence 0.06 Published 2003 Journal Clin. Exp. Med. Section Abstract Doc Link 12748878 Disease Relevance 1.00 Pain Relevance 0.19

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