INT88032

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Context Info
Confidence 0.32
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.27
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PCSK1) extracellular space (PCSK1) small molecule metabolic process (PCSK1)
Golgi apparatus (PCSK1) embryo development (PCSK1) cellular nitrogen compound metabolic process (PCSK1)
Anatomy Link Frequency
muscle 1
intestinal epithelium 1
knee 1
PCSK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 13 99.40 Very High Very High Very High
Inflammation 14 86.48 High High
visual analogue scale 1 73.04 Quite High
addiction 1 54.16 Quite High
Enkephalin 1 25.00 Low Low
Osteoarthritis 14 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neonatal Necrotizing Enterocolitis 34 100.00 Very High Very High Very High
Myalgia 4 99.68 Very High Very High Very High
Disease 6 99.58 Very High Very High Very High
Pain 5 86.84 High High
INFLAMMATION 14 86.48 High High
Injury 11 70.12 Quite High
Nociception 1 54.12 Quite High
Osteoarthritis 11 5.00 Very Low Very Low Very Low
Obesity 8 5.00 Very Low Very Low Very Low
Aging 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The alpha-1 EEG powers at P3, Pz, P4, PC1, PC2 and POz, and alpha-2 at Pz and POz sites were significantly decreased during muscle pain when compared with aversive noise stimulation.
Negative_regulation (decreased) of PC1 in muscle associated with pain and myalgia
1) Confidence 0.32 Published 2002 Journal Exp Brain Res Section Abstract Doc Link 12428146 Disease Relevance 0.60 Pain Relevance 0.81
PC1 of the knee adduction moment explained 85% of the variability in the original knee adduction moment waveforms and was interpreted as the overall magnitude of the moment during the stance phase of the gait cycle, because the loading vector was constant and positive over the majority of the stance phase (Figure 3b).
Negative_regulation (interpreted) of PC1 in knee
2) Confidence 0.31 Published 2010 Journal Acta Orthopaedica Section Body Doc Link PMC2917572 Disease Relevance 0 Pain Relevance 0
We constructed two PC2 mutants in which residues 242 and 243 and residues 242-248 were replaced with the corresponding residues of PC1.
Negative_regulation (residues) of PC1
3) Confidence 0.17 Published 2000 Journal J. Biol. Chem. Section Abstract Doc Link 10799554 Disease Relevance 0 Pain Relevance 0
Our studies thus contribute to our understanding of how the intestinal epithelium participates in the innate immune response to PAF and bacterial ligands in neonatal NEC, and opens the door for future experimental studies and possibly even targeted therapies to limit disease, or perhaps even to prevent NEC in at risk patients.



Negative_regulation (prevent) of NEC in intestinal epithelium associated with neonatal necrotizing enterocolitis and disease
4) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0.67 Pain Relevance 0.11

General Comments

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