INT88046

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Context Info
Confidence 0.76
First Reported 2000
Last Reported 2010
Negated 6
Speculated 0
Reported most in Body
Documents 38
Total Number 49
Disease Relevance 33.76
Pain Relevance 28.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ccr2) plasma membrane (Ccr2) cytoplasm (Ccr2)
signal transducer activity (Ccr2)
Anatomy Link Frequency
neuronal 8
spinal cord 4
neurons 4
nerve 3
sensory neurons 2
Ccr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 2133 100.00 Very High Very High Very High
analgesia 240 99.96 Very High Very High Very High
Neuropathic pain 694 99.92 Very High Very High Very High
antagonist 796 99.82 Very High Very High Very High
Demyelination 546 99.76 Very High Very High Very High
Eae 427 99.70 Very High Very High Very High
Spinal cord 587 99.68 Very High Very High Very High
dorsal root ganglion 841 99.58 Very High Very High Very High
central pain 8 99.54 Very High Very High Very High
Inflammation 113 99.34 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 310 99.96 Very High Very High Very High
Neuropathic Pain 1098 99.92 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 431 99.84 Very High Very High Very High
Demyelinating Disease 576 99.76 Very High Very High Very High
Injury 1152 99.70 Very High Very High Very High
Ganglion Cysts 853 99.58 Very High Very High Very High
Pain 484 99.54 Very High Very High Very High
Spinal Cord Injury 24 99.44 Very High Very High Very High
INFLAMMATION 175 99.34 Very High Very High Very High
Nervous System Injury 516 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CCL2-evoked activation was also observed as a calcium-mediated excitation occurring in engineered cells expressing CCR2 as well as in both neuronal and non-neuronal cells from the DRG and in the spinal cord.
Gene_expression (expressing) of CCR2 in spinal cord associated with spinal cord
1) Confidence 0.76 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009975 Disease Relevance 0.29 Pain Relevance 0.41
qi5) stably expressing the rat CCR2 receptor were selected and further profiled by performing dose-response curves.
Gene_expression (expressing) of CCR2 receptor
2) Confidence 0.76 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009975 Disease Relevance 0.26 Pain Relevance 0.47
Reports analyzing CCR2 expression in neuropathic conditions showed either predominantly non-neuronal CCR2 [14,30] or presence of the receptor in both neuronal and non-neuronal cells [18-20].
Gene_expression (expression) of CCR2 in neuronal associated with neuropathic pain
3) Confidence 0.76 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009975 Disease Relevance 0.35 Pain Relevance 0.39
It is however possible that different neuropathic models used could explain variations in CCR2 expression.
Gene_expression (expression) of CCR2 associated with neuropathic pain
4) Confidence 0.76 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009975 Disease Relevance 0.40 Pain Relevance 0.43
A peripheral site of action was proposed based on the predominantly peripheral expression and activation of CCR2 in a demyelination injury model of neuropathic pain [17].
Gene_expression (expression) of CCR2 associated with demyelination, injury and neuropathic pain
5) Confidence 0.76 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009975 Disease Relevance 0.49 Pain Relevance 1.04
CCR2 expression in sensory cells could support either a peripheral or a central site of action of CCR2 in analgesia depending on the particular location of the receptor (nerve, cell body or axon terminals in the spinal cord).
Gene_expression (expression) of CCR2 in nerve associated with spinal cord and analgesia
6) Confidence 0.76 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009975 Disease Relevance 0.50 Pain Relevance 1.08
Thus, AZ889 represents a novel, potent, selective and functionally active antagonist for the CCR2 chemokine receptor producing analgesia in vivo in the CCI model at concentrations that are relevant in vitro.
Gene_expression (producing) of CCR2 chemokine receptor associated with chemokine, eae, antagonist and analgesia
7) Confidence 0.76 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009975 Disease Relevance 0.16 Pain Relevance 0.47
The focus of the current study was the investigation of time-dependent CCL2 and CCR2 expression in relation to central neuropathic pain development after spinal cord impact lesions of 100, 150, or 200 kdyn force on spinal cord level T9 in adult rats.
Gene_expression (expression) of CCR2 in spinal cord associated with neuropathic pain and spinal cord
8) Confidence 0.70 Published 2008 Journal J. Neurotrauma Section Abstract Doc Link 18338959 Disease Relevance 1.22 Pain Relevance 0.78
Force-dependent development of neuropathic central pain and time-related CCL2/CCR2 expression after graded spinal cord contusion injuries of the rat.
Gene_expression (expression) of CCR2 in spinal cord associated with pain, central pain, inflammation, injury, neuropathic pain and spinal cord
9) Confidence 0.70 Published 2008 Journal J. Neurotrauma Section Title Doc Link 18338959 Disease Relevance 1.44 Pain Relevance 1.18
While in the early post-operative time course, CCL2 and CCR2 were expressed in astroglia and granulocytes only on level T9; there was additional astroglial CCL2 expression in dorsal columns and dorsal horns above and below T9 of severely injured animals 42d after lesion.
Gene_expression (expressed) of CCR2 in dorsal
10) Confidence 0.70 Published 2008 Journal J. Neurotrauma Section Abstract Doc Link 18338959 Disease Relevance 1.40 Pain Relevance 0.95
We therefore examined the state of CCR2 expression in association with LPC-induced demyelination.
Gene_expression (expression) of CCR2 associated with demyelination
11) Confidence 0.68 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.90 Pain Relevance 0.57
If that is the case it is also possible that drugs which block several upregulated chemokine receptors may also prove to be effective if they are upstream of CCR2 expression.
Gene_expression (expression) of CCR2 associated with chemokine
12) Confidence 0.68 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.68 Pain Relevance 0.64
It is also likely that the CCR2R antagonist may impact non-neuronal cells within the CNS, such as microglial cells, which are known to express CCR2 in the spinal cord and contribute to the development of chronic pain states [11,48,49].
Gene_expression (express) of CCR2 in neuronal associated with lasting pain, antagonist and spinal cord
13) Confidence 0.68 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.71 Pain Relevance 1.05
As with CCR2 expression in sensory neurons, CCR5 mRNA transcript levels were strongly increased in many sensory neurons ipsilateral and contralateral to the nerve injury at POD14 (Fig. 5D).
Gene_expression (expression) of CCR2 in nerve associated with nervous system injury
14) Confidence 0.68 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.68 Pain Relevance 0.39
CCR2 mRNA was no longer detected in lumbar DRGs taken from injured animals on POD35 (data not shown).
Neg (no) Gene_expression (detected) of CCR2 mRNA
15) Confidence 0.68 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.37 Pain Relevance 0.53
L4L5 DRGs removed from naïve (data not shown) and vehicle-treated rats at POD7 did not express CCR2 mRNA (Fig. 2A) or CCR2 immunoreactivity (Fig. 2B).
Neg (not) Gene_expression (express) of CCR2 mRNA
16) Confidence 0.68 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.80 Pain Relevance 0.59
Despite a report to the contrary [15], we did not observe increased expression of either MCP1 or the CCR2 following ddC treatment.
Gene_expression (expression) of CCR2
17) Confidence 0.67 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.79 Pain Relevance 0.43
The combination of a T-tropic form of gp120 with hCD4 did not alter the expression or functional signaling of SDF1/CXCR4 in the DRG, however, increased expression of both MCP1 and CCR2 was observed, in addition to increased functional signaling via CCR2.
Gene_expression (expression) of CCR2 associated with dorsal root ganglion
18) Confidence 0.67 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 1.11 Pain Relevance 0.64
Coexpression of the TRPV1 receptor channel with CCR2 receptors
Gene_expression (Coexpression) of CCR2
19) Confidence 0.67 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.46 Pain Relevance 0.49
Indeed, administration of a CCR2 RA blocked mechanical hypernociception in a focal demyelination model in which both MCP1 and CCR2 expression were upregulated [24,38].
Gene_expression (expression) of CCR2 associated with demyelination and rheumatoid arthritis
20) Confidence 0.67 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 1.25 Pain Relevance 0.56

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