INT88047

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Context Info
Confidence 0.60
First Reported 2000
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 15
Total Number 17
Disease Relevance 10.50
Pain Relevance 8.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ccr2) plasma membrane (Ccr2) cytoplasm (Ccr2)
signal transducer activity (Ccr2)
Anatomy Link Frequency
neuronal 7
neurons 5
sensory neurons 4
nerve 2
spinal cord 2
Ccr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 794 100.00 Very High Very High Very High
Neuropathic pain 228 99.92 Very High Very High Very High
central pain 2 99.90 Very High Very High Very High
dorsal root ganglion 378 99.78 Very High Very High Very High
Demyelination 168 99.76 Very High Very High Very High
Inflammation 35 99.72 Very High Very High Very High
Spinal cord 151 99.44 Very High Very High Very High
imagery 84 99.32 Very High Very High Very High
neuralgia 5 98.80 Very High Very High Very High
peripheral neuropathy 48 97.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 424 99.98 Very High Very High Very High
Neuropathic Pain 331 99.92 Very High Very High Very High
Pain 151 99.90 Very High Very High Very High
Ganglion Cysts 381 99.78 Very High Very High Very High
Demyelinating Disease 180 99.76 Very High Very High Very High
INFLAMMATION 59 99.72 Very High Very High Very High
Spinal Cord Injury 6 99.44 Very High Very High Very High
Rheumatoid Arthritis 123 98.18 Very High Very High Very High
Nervous System Injury 174 97.52 Very High Very High Very High
Peripheral Neuropathy 48 97.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Despite a report to the contrary [15], we did not observe increased expression of either MCP1 or the CCR2 following ddC treatment.
Neg (not) Positive_regulation (increased) of Gene_expression (expression) of CCR2
1) Confidence 0.60 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.80 Pain Relevance 0.43
Thus, the fura-2 imaging generally confirmed the observed upregulated CCR2 expression in sensory neurons following perineural gp120/hCD4 treatment.
Positive_regulation (upregulated) of Gene_expression (expression) of CCR2 in sensory neurons associated with imagery
2) Confidence 0.60 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.23 Pain Relevance 0.56
Injury induced alteration of CCR2 mRNA and protein expression in lumbar DRG
Positive_regulation (induced) of Gene_expression (expression) of CCR2 mRNA associated with dorsal root ganglion and injury
3) Confidence 0.60 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.41 Pain Relevance 0.18
Indeed, administration of a CCR2 RA blocked mechanical hypernociception in a focal demyelination model in which both MCP1 and CCR2 expression were upregulated [24,38].
Positive_regulation (upregulated) of Gene_expression (expression) of CCR2 associated with demyelination and rheumatoid arthritis
4) Confidence 0.60 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 1.25 Pain Relevance 0.56
A peripheral site of action was proposed based on the predominantly peripheral expression and activation of CCR2 in a demyelination injury model of neuropathic pain [17].
Positive_regulation (activation) of Gene_expression (expression) of CCR2 associated with demyelination, injury and neuropathic pain
5) Confidence 0.49 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009975 Disease Relevance 0.49 Pain Relevance 1.04
CCR2 expression was increased in various human inflammatory conditions [29] and in rodent neuropathic models [2,11,19,20,30].
Positive_regulation (increased) of Gene_expression (expression) of CCR2 associated with inflammation and neuropathic pain
6) Confidence 0.45 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009975 Disease Relevance 1.04 Pain Relevance 0.94
Force-dependent development of neuropathic central pain and time-related CCL2/CCR2 expression after graded spinal cord contusion injuries of the rat.
Positive_regulation (time-related) of Gene_expression (expression) of CCR2 in spinal cord associated with pain, central pain, inflammation, injury, neuropathic pain and spinal cord
7) Confidence 0.45 Published 2008 Journal J. Neurotrauma Section Title Doc Link 18338959 Disease Relevance 1.44 Pain Relevance 1.19
As with CCR2 expression in sensory neurons, CCR5 mRNA transcript levels were strongly increased in many sensory neurons ipsilateral and contralateral to the nerve injury at POD14 (Fig. 5D).
Positive_regulation (increased) of Gene_expression (expression) of CCR2 in nerve associated with nervous system injury
8) Confidence 0.44 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.71 Pain Relevance 0.41
CCR2 mRNA expression studies were used for receptor localization because of the failure of immunocytochemistry to detect neuronal CCR2 protein.
Positive_regulation (used) of Gene_expression (detect) of CCR2 protein in neuronal
9) Confidence 0.44 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.06 Pain Relevance 0.08
CCR2 mRNA expression studies were used for receptor localization because of the failure of immunocytochemistry to detect neuronal CCR2 protein.
Positive_regulation (used) of Gene_expression (expression) of CCR2 mRNA in neuronal
10) Confidence 0.44 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.06 Pain Relevance 0.08
The combination of perineural gp120/hCD4 treatment with ddC produced increased neuronal expression of both CXCR4 and CCR2 receptors together with their respective ligands, SDF1 and MCP1 in rather distinct subpopulations of sensory neurons.
Positive_regulation (increased) of Gene_expression (expression) of CCR2 in sensory neurons
11) Confidence 0.43 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.57 Pain Relevance 0.42
However, when both treatments were combined, rather than observing the increased expression of either MCP1/CCR2 or SDF1/CXCR4, both chemokine signaling systems were upregulated and this was observed to occur mostly in neurons.
Positive_regulation (increased) of Gene_expression (expression) of CCR2 in neurons associated with chemokine
12) Confidence 0.43 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.85 Pain Relevance 0.39
could then initiate an "inflammatory" cascade and increased neuronal expression of MCP1 and CCR2.
Positive_regulation (increased) of Gene_expression (expression) of CCR2 in neuronal associated with inflammation
13) Confidence 0.43 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.67 Pain Relevance 0.31
The combination of a T-tropic form of gp120 with hCD4 did not alter the expression or functional signaling of SDF1/CXCR4 in the DRG, however, increased expression of both MCP1 and CCR2 was observed, in addition to increased functional signaling via CCR2.
Positive_regulation (increased) of Gene_expression (expression) of CCR2 associated with dorsal root ganglion
14) Confidence 0.43 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 1.12 Pain Relevance 0.64
We found that in sham treated tissues, 30.8 ± 1.3% of neurons expressed the TRPV1 protein, while there was no CCR2 expression (Fig. 3D, G).
Neg (no) Positive_regulation (was) of Neg (no) Gene_expression (expression) of CCR2 in neurons
15) Confidence 0.43 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.47 Pain Relevance 0.43
Despite this observation, our results could indicate either the presence of CCR2 on both cell types or that CCL2-evoked neuronal activation is indirectly mediated following glial CCR2 excitation and release of a gliotransmitter onto neurons.
Positive_regulation (mediated) of in neuronal Gene_expression (excitation) of CCR2 in neurons
16) Confidence 0.43 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009975 Disease Relevance 0.33 Pain Relevance 0.42
In contrast to these results, a significant elevation in the expression of the chemokine receptor CCR2 was observed in U50,488H-treated cultures.
Positive_regulation (elevation) of Gene_expression (expression) of chemokine receptor CCR2 associated with chemokine
17) Confidence 0.02 Published 2000 Journal J. Immunol. Section Abstract Doc Link 10799865 Disease Relevance 0 Pain Relevance 0.56

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