INT88063

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Context Info
Confidence 0.37
First Reported 2000
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.35
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ptger4) signal transducer activity (Ptger4)
Anatomy Link Frequency
neurons 1
afferent neurons 1
Ptger4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 8 98.16 Very High Very High Very High
Inflammation 2 96.88 Very High Very High Very High
acular 4 92.88 High High
cINOD 5 92.40 High High
antinociception 1 88.04 High High
analgesia 1 87.24 High High
cytokine 1 86.12 High High
tetrodotoxin 1 82.32 Quite High
excitatory amino acid 1 63.52 Quite High
substance P 3 61.60 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 3 96.88 Very High Very High Very High
Frailty 1 94.40 High High
Nociception 5 71.60 Quite High
Pain 1 35.52 Quite Low
Hyperalgesia 1 28.48 Quite Low
Neuropathic Pain 1 27.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of the present study was to verify the hypothesis that prostaglandins (PGs) play a site-specific role in activating selective groups of neurons via a privileged interaction between PG of the E2 type and its EP4 receptor.
EP4 receptor Binding (interaction) of in neurons
1) Confidence 0.37 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10800959 Disease Relevance 0 Pain Relevance 0.21
Prostaglandins then bind to G-protein-coupled receptors located in intrinsic spinal neurons (receptor types DP and EP2) and primary afferent neurons (EP1, EP3, EP4 and IP).
EP4 Binding (bind) of in afferent neurons
2) Confidence 0.02 Published 2001 Journal Prog. Neurobiol. Section Abstract Doc Link 11275357 Disease Relevance 0.35 Pain Relevance 0.99

General Comments

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