INT88079

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Context Info
Confidence 0.76
First Reported 1999
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 22
Disease Relevance 8.52
Pain Relevance 6.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Chrna4) transport (Chrna4) plasma membrane (Chrna4)
neurological system process (Chrna4)
Anatomy Link Frequency
peripheral nervous system 2
brain 1
forebrain 1
lung 1
oocytes 1
Chrna4 (Mus musculus)
Pain Link Frequency Relevance Heat
Potency 6 99.92 Very High Very High Very High
cINOD 32 99.78 Very High Very High Very High
Peripheral nervous system 9 99.68 Very High Very High Very High
Central nervous system 6 99.68 Very High Very High Very High
Inflammation 191 99.54 Very High Very High Very High
Nicotine 633 99.16 Very High Very High Very High
Pain 6 98.58 Very High Very High Very High
IPN 4 98.48 Very High Very High Very High
antagonist 18 97.64 Very High Very High Very High
analgesia 2 97.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Lung Cancer 72 99.60 Very High Very High Very High
INFLAMMATION 211 99.54 Very High Very High Very High
Hypoxia 62 99.12 Very High Very High Very High
Adenocarcinoma 15 98.92 Very High Very High Very High
Pain 6 98.58 Very High Very High Very High
Cancer 276 97.88 Very High Very High Very High
Aging 14 97.76 Very High Very High Very High
Nicotine Addiction 91 97.16 Very High Very High Very High
Targeted Disruption 29 95.76 Very High Very High Very High
Cognitive Disorder 19 95.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the in vivo antagonistic potency of dextrometorphan and dextrorphan in the pain tests does not correlate well with their in vitro blockade potency at expressed nAChR subtypes.
Gene_expression (expressed) of nAChR associated with pain and potency
1) Confidence 0.76 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15356218 Disease Relevance 0.16 Pain Relevance 0.86
Mutations targeted to nAChR subunits that are highly expressed in the peripheral nervous system have opened a window on the complex mechanisms governing autonomic control of peripheral organs.
Gene_expression (expressed) of nAChR in peripheral nervous system associated with peripheral nervous system
2) Confidence 0.59 Published 2002 Journal Curr Drug Targets CNS Neurol Disord Section Abstract Doc Link 12769607 Disease Relevance 0.49 Pain Relevance 0.42
Mice with nAChR mutations targeted to subunits that are highly expressed in the CNS have brought insight into the nAChR mechanisms involved in nicotine addiction, analgesia, aging, and nicotine-induced behaviors.
Gene_expression (expressed) of nAChR associated with addiction, aging, nicotine and analgesia
3) Confidence 0.59 Published 2002 Journal Curr Drug Targets CNS Neurol Disord Section Abstract Doc Link 12769607 Disease Relevance 0.53 Pain Relevance 0.43
In oocytes expressing various neuronal acetylcholine nicotinic receptors (nAChR), dextrometorphan and dextrorphan blocked nicotine activation of expressed alpha(3)beta(4), alpha(4)beta(2), and alpha(7) subtypes with a small degree of selectivity.
Gene_expression (expressing) of nAChR in oocytes associated with nicotine
4) Confidence 0.59 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15356218 Disease Relevance 0.15 Pain Relevance 0.90
Because the mouse is a useful model for age-related decline in nAChR expression in the basal forebrain and limbic system, we used immunohistochemistry to examine the influence of long-term (12-month) oral administration of nicotine and/or the cyclooxygenase-2 (COX-2) preferring non-steroidal anti-inflammatory drug (NSAID) NS398 on nAChR alpha4, alpha5, alpha7, and beta4 expression in the C57BL/6 mouse.
Gene_expression (expression) of nAChR alpha4 in forebrain associated with inflammation, nicotine, cinod and limbic system
5) Confidence 0.46 Published 2005 Journal J. Neurobiol. Section Abstract Doc Link 15551346 Disease Relevance 0.35 Pain Relevance 0.56
The beta 2 nAChR is most widely expressed in the central nervous system, and is involved in the functional high-affinity nicotine receptor regulating cognitive performance and the mesolimbic dopamine system.
Gene_expression (expressed) of nAChR in central nervous system associated with cognitive disorder, dopamine, nicotine and central nervous system
6) Confidence 0.39 Published 1999 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 10803206 Disease Relevance 0.31 Pain Relevance 0.30
Immunolabeling demonstrates the interdependence of mouse brain alpha4 and beta2 nicotinic acetylcholine receptor subunit expression.
Gene_expression (expression) of alpha4 in brain
7) Confidence 0.34 Published 2006 Journal J. Comp. Neurol. Section Title Doc Link 17072836 Disease Relevance 0 Pain Relevance 0.10
Therefore, alpha4 subunit expression is almost universally beta2-dependent.
Gene_expression (expression) of alpha4
8) Confidence 0.34 Published 2006 Journal J. Comp. Neurol. Section Abstract Doc Link 17072836 Disease Relevance 0 Pain Relevance 0.13
In situ mRNA hybridization was also performed to determine if altered mRNA transcription mediated the interdependence of alpha4 and beta2 subunit expression. alpha4-Null mutation did not affect beta2 mRNA expression, nor did beta2 genotype affect alpha4 mRNA expression.
Gene_expression (expression) of alpha4
9) Confidence 0.34 Published 2006 Journal J. Comp. Neurol. Section Abstract Doc Link 17072836 Disease Relevance 0 Pain Relevance 0.09
In situ mRNA hybridization was also performed to determine if altered mRNA transcription mediated the interdependence of alpha4 and beta2 subunit expression. alpha4-Null mutation did not affect beta2 mRNA expression, nor did beta2 genotype affect alpha4 mRNA expression.
Gene_expression (expression) of alpha4
10) Confidence 0.34 Published 2006 Journal J. Comp. Neurol. Section Abstract Doc Link 17072836 Disease Relevance 0 Pain Relevance 0.10
7 nAChR subunit in mouse lung cancer
Gene_expression (subunit) of nAChR in lung associated with lung cancer
11) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759510 Disease Relevance 1.05 Pain Relevance 0.57
7 nAChR subunit. ?
Gene_expression (subunit.) of nAChR
12) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759510 Disease Relevance 0.90 Pain Relevance 0.56
7 nAChR subunit expression.
Gene_expression (expression) of nAChR
13) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759510 Disease Relevance 0.86 Pain Relevance 0.55
Individual nAChR channels have unique biological functions that are determined by the pentameric combination of 11 distinct subunits: ?
Gene_expression (channels) of nAChR
14) Confidence 0.06 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0.04
7* nAChR levels resulted from Nrg1 intracellular domain–induced synthesis of ?
Gene_expression (levels) of nAChR
15) Confidence 0.06 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0
7* nAChR levels; Type III Nrg1 functioning as a receptor can regulate insertion of preformed ?
Gene_expression (levels) of nAChR
16) Confidence 0.06 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0
7* nAChR surface expression.
Gene_expression (expression) of nAChR
17) Confidence 0.06 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0.04
7* nAChR surface expression (Fig. 6).
Gene_expression (expression) of nAChR
18) Confidence 0.05 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0
Furthermore, to preclude the possibility that nicotine and/or hypoxia may impart pro-survival cues by modulating nAChR gene expression, we showed by real-time PCR analysis that neither nicotine nor hypoxia significantly affected the gene expression of ?
Gene_expression (expression) of nAChR gene associated with hypoxia and nicotine
19) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737633 Disease Relevance 1.31 Pain Relevance 0.43
Quantitative real-time PCR expression of nAChRs in hESC-ECs and HMVDECs, expressed as relative fold changes with respect to hESCs, showed comparable gene expression levels for nAChR ?
Gene_expression (expression) of nAChR
20) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737633 Disease Relevance 0 Pain Relevance 0.06

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