INT88081

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Context Info
Confidence 0.59
First Reported 1999
Last Reported 2010
Negated 0
Speculated 3
Reported most in Abstract
Documents 45
Total Number 49
Disease Relevance 16.56
Pain Relevance 37.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprm1) plasma membrane (Oprm1) signal transducer activity (Oprm1)
Anatomy Link Frequency
NS20Y 4
neurons 4
dorsal root ganglia 4
thalamus 4
A band 4
Oprm1 (Mus musculus)
Pain Link Frequency Relevance Heat
mu opioid receptor 1274 100.00 Very High Very High Very High
opioid receptor 753 100.00 Very High Very High Very High
Morphine 266 100.00 Very High Very High Very High
Pain 65 100.00 Very High Very High Very High
dorsal root ganglion 18 100.00 Very High Very High Very High
antagonist 24 99.98 Very High Very High Very High
withdrawal 18 99.96 Very High Very High Very High
Calcitonin gene-related peptide 4 99.72 Very High Very High Very High
agonist 113 99.68 Very High Very High Very High
Cannabinoid receptor 13 99.58 Very High Very High Very High
Disease Link Frequency Relevance Heat
Repression 142 100.00 Very High Very High Very High
Ganglion Cysts 23 100.00 Very High Very High Very High
Sarcoma 15 100.00 Very High Very High Very High
Opiate Addiction 35 99.92 Very High Very High Very High
Nervous System Injury 8 99.92 Very High Very High Very High
Urological Neuroanatomy 30 99.44 Very High Very High Very High
Post Operative Pain 8 99.44 Very High Very High Very High
Nociception 7 99.40 Very High Very High Very High
Endometriosis (extended) 14 99.12 Very High Very High Very High
Pain 32 98.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To investigate further the possible changes in MOR function to activate G-proteins under the condition of a reduced MOR-1B expression, the guanosine-5'-o-(3-[35S]thio)triphosphate ([35S]GTPgammaS) binding assay was performed.
Negative_regulation (reduced) of Gene_expression (expression) of MOR associated with opioid receptor
1) Confidence 0.59 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14686893 Disease Relevance 0.26 Pain Relevance 0.88
Reduced expression of a novel mu-opioid receptor (MOR) subtype MOR-1B in CXBK mice: implications of MOR-1B in the expression of MOR-mediated responses.
Negative_regulation (Reduced) of Gene_expression (expression) of MOR associated with pain and opioid receptor
2) Confidence 0.59 Published 2003 Journal Eur. J. Neurosci. Section Title Doc Link 14686893 Disease Relevance 0.20 Pain Relevance 1.07
These effects on ethanol reward were produced by reductions in MOR expression levels as small as 50%.
Negative_regulation (reductions) of Gene_expression (expression) of MOR
3) Confidence 0.58 Published 2001 Journal Psychopharmacology (Berl.) Section Body Doc Link 11292005 Disease Relevance 0 Pain Relevance 0
The disruptions of mu receptor expression decreases the nociceptive threshold to thermal stimuli and increases the threshold to visceral chemical stimuli paradoxically.
Negative_regulation (disruptions) of Gene_expression (expression) of mu receptor in visceral associated with nociception
4) Confidence 0.57 Published 1999 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 10803207 Disease Relevance 0.52 Pain Relevance 0.84
In particular, MOR expression was reduced among calcitonin gene-related peptide- and transient receptor potential vanilloid subfamily 1-positive DRG neuronal profiles, which are considered to be involved in the generation of bone cancer pain (from 61.5% to 41.5% and from 72.1% to 48.4%, respectively).
Negative_regulation (reduced) of Gene_expression (expression) of MOR in neuronal associated with dorsal root ganglion, cancer pain, opioid receptor, bone cancer and calcitonin gene-related peptide
5) Confidence 0.57 Published 2008 Journal Neuroscience Section Abstract Doc Link 18178319 Disease Relevance 1.62 Pain Relevance 1.69
Down-regulation of mu opioid receptor expression within distinct subpopulations of dorsal root ganglion neurons in a murine model of bone cancer pain.
Negative_regulation (Down-regulation) of Gene_expression (expression) of mu opioid receptor in neurons associated with ganglion cysts, cancer pain, root ganglion neuron, mu opioid receptor and bone cancer
6) Confidence 0.57 Published 2008 Journal Neuroscience Section Title Doc Link 18178319 Disease Relevance 1.27 Pain Relevance 1.35
The CXBK mice are characterized by reduced sensitivity to morphine and by partial deficiency in mu-opioid receptor (MOR) expression.
Spec (partial) Negative_regulation (deficiency) of Gene_expression (expression) of MOR associated with opioid receptor and morphine
7) Confidence 0.56 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15562256 Disease Relevance 0 Pain Relevance 0.44
Translational repression of mouse mu opioid receptor expression via leaky scanning

Mu opioid receptor (MOR) expression is under temporal and spatial controls, but expression levels of the MOR gene are relatively low in vivo.

Negative_regulation (repression) of Gene_expression (expression) of MOR associated with repression and mu opioid receptor
8) Confidence 0.52 Published 2007 Journal Nucleic Acids Research Section Title Doc Link PMC1865057 Disease Relevance 0.27 Pain Relevance 0.43
Translational repression of mouse mu opioid receptor expression via leaky scanning

Mu opioid receptor (MOR) expression is under temporal and spatial controls, but expression levels of the MOR gene are relatively low in vivo.

Negative_regulation (repression) of Gene_expression (expression) of mu opioid receptor associated with repression and mu opioid receptor
9) Confidence 0.52 Published 2007 Journal Nucleic Acids Research Section Title Doc Link PMC1865057 Disease Relevance 0.26 Pain Relevance 0.42
ChIP and re-ChIP assay revealed that Sp3 and NRSF were presented together on 188 bp MOR DNA segment for synergic downregulation of MOR expression
Negative_regulation (downregulation) of Gene_expression (expression) of MOR associated with mu opioid receptor
10) Confidence 0.50 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0 Pain Relevance 0.23
The same result was obtained using c-Myc-tagged NRSF expressed in NS20Y cells implying that Sp3 binds the GC box and a direct interaction between Sp3 and NRSF is required for a synergistic repression of MOR gene expression (Figure 4B).
Negative_regulation (repression) of Gene_expression (expression) of MOR in NS20Y associated with repression and mu opioid receptor
11) Confidence 0.50 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0.10 Pain Relevance 0.18
Here we found for the first time that CXBK recombinant-inbred mice display a significant reduction in the expression of MOR-1B mRNA in the brain as compared to that in their progenitor C57BL/6 mice.
Negative_regulation (reduction) of Gene_expression (expression) of MOR-1B mRNA in brain associated with opioid receptor
12) Confidence 0.43 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14686893 Disease Relevance 0.15 Pain Relevance 0.61
The present data provide first evidence that a lack of MOR-1B expression may, at least in part, contribute to the reduced sensitivity to MOR agonists in CXBK mice, and MOR-1B may play a potential role in the MOR-mediated supraspinal antinociception.
Negative_regulation (lack) of Gene_expression (expression) of MOR associated with antinociception, agonist and opioid receptor
13) Confidence 0.43 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14686893 Disease Relevance 0.20 Pain Relevance 1.11
Reduced expression of a novel mu-opioid receptor (MOR) subtype MOR-1B in CXBK mice: implications of MOR-1B in the expression of MOR-mediated responses.
Negative_regulation (Reduced) of Gene_expression (expression) of MOR associated with pain and opioid receptor
14) Confidence 0.43 Published 2003 Journal Eur. J. Neurosci. Section Title Doc Link 14686893 Disease Relevance 0.21 Pain Relevance 1.09
Reduced expression of a novel mu-opioid receptor (MOR) subtype MOR-1B in CXBK mice: implications of MOR-1B in the expression of MOR-mediated responses.
Negative_regulation (Reduced) of Gene_expression (expression) of mu-opioid receptor associated with pain and opioid receptor
15) Confidence 0.43 Published 2003 Journal Eur. J. Neurosci. Section Title Doc Link 14686893 Disease Relevance 0.20 Pain Relevance 1.07
Our findings may promote a better understanding of the molecular mechanisms underlying Oprm1 expression.



Negative_regulation (underlying) of Gene_expression (expression) of Oprm1
16) Confidence 0.43 Published 2008 Journal Molecular & Cellular Proteomics : MCP Section Body Doc Link PMC2494908 Disease Relevance 0 Pain Relevance 0
CB(2) cannabinoid receptor antagonist SR144528 decreases mu-opioid receptor expression and activation in mouse brainstem: role of CB(2) receptor in pain.
Negative_regulation (decreases) of Gene_expression (expression) of mu-opioid receptor in brainstem associated with endocannabinoid, pain, medulla, cannabinoid receptor, antagonist and opioid receptor
17) Confidence 0.42 Published 2008 Journal Neurochem. Int. Section Title Doc Link 18804501 Disease Relevance 0.10 Pain Relevance 1.27
Western blot analysis showed that MOR expression in the dorsal root ganglion (DRG) ipsilateral to sarcoma implantation was significantly reduced, while that in the DRG ipsilateral to CFA injection was increased.
Negative_regulation (reduced) of Gene_expression (expression) of MOR in DRG associated with ganglion cysts, dorsal root ganglion, sarcoma and opioid receptor
18) Confidence 0.41 Published 2008 Journal Neuroscience Section Abstract Doc Link 18178319 Disease Relevance 1.72 Pain Relevance 1.63
The CXBK mice are characterized by reduced sensitivity to morphine and by partial deficiency in mu-opioid receptor (MOR) expression.
Spec (partial) Negative_regulation (deficiency) of Gene_expression (expression) of mu-opioid receptor associated with opioid receptor and morphine
19) Confidence 0.41 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15562256 Disease Relevance 0 Pain Relevance 0.44
The results confirmed that these uORFs mediated down-regulation of MOR expression.
Negative_regulation (down-regulation) of Gene_expression (expression) of MOR associated with mu opioid receptor
20) Confidence 0.38 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1865057 Disease Relevance 0.09 Pain Relevance 0.20

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