INT88083

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.58
First Reported 1999
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.88
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Drd3) plasma membrane (Drd3) signal transducer activity (Drd3)
Anatomy Link Frequency
forebrain 2
Drd3 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 10 100.00 Very High Very High Very High
dopamine receptor 5 99.86 Very High Very High Very High
midbrain 1 93.84 High High
Dynorphin 1 90.00 High High
Neurobehavioral 1 80.80 Quite High
Morphine 2 76.44 Quite High
Enkephalin 1 74.16 Quite High
Central nervous system 1 70.80 Quite High
cocaine 2 45.36 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 10 93.76 High High
Toxicity 4 87.96 High High
Hyperplasia 1 66.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present data provide further evidence that prenatal and neonatal exposure to BPA leads to the reduction of functional dopamine D3 receptors without affecting the new synthesis of dopamine D3 receptors in the mouse limbic forebrain.
Negative_regulation (reduction) of dopamine D3 in forebrain associated with dopamine
1) Confidence 0.58 Published 2004 Journal Addict Biol Section Abstract Doc Link 15203435 Disease Relevance 0.07 Pain Relevance 0.42
Additionally, this treatment with bisphenol-A produced a down-regulation of dopamine D3 receptor and an up-regulation of dopamine D1 receptor function to activate G-protein in the mouse limbic forebrain, which is thought to play a critical role for rewarding effects by drugs of abuse.
Negative_regulation (down-regulation) of dopamine D3 receptor in forebrain associated with dopamine
2) Confidence 0.45 Published 2005 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 16045194 Disease Relevance 0.17 Pain Relevance 0.23
To study the functions of each dopamine receptors, mice lacking each of D1R, D2R, D3R and D4R dopamine receptors have been generated.
Negative_regulation (lacking) of D3R associated with dopamine receptor
3) Confidence 0.16 Published 1999 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 10803208 Disease Relevance 0.65 Pain Relevance 0.35

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox