INT88121

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Context Info
Confidence 0.22
First Reported 2000
Last Reported 2005
Negated 2
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.92
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gsr) mitochondrion (Gsr) oxidoreductase activity (Gsr)
cytoplasm (Gsr)
Anatomy Link Frequency
erythrocytes 1
Gsr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 3 98.00 Very High Very High Very High
corticosteroid 4 75.00 Quite High
cINOD 4 65.24 Quite High
aspirin 2 50.00 Quite Low
cytokine 1 40.20 Quite Low
Inflammation 2 39.80 Quite Low
Disease Link Frequency Relevance Heat
Toxicity 3 98.22 Very High Very High Very High
Cancer 4 96.96 Very High Very High Very High
Necrosis 4 96.72 Very High Very High Very High
INFLAMMATION 5 65.00 Quite High
Injury 2 63.96 Quite High
Adhesions 1 42.84 Quite Low
Enteropathy 1 35.44 Quite Low
Ulcers 1 5.00 Very Low Very Low Very Low
Stress 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Despite inhibiting cyclooxygenase activity, the attenuation of (S)-(+)-ketoprofen-induced intestinal toxicity could be correlated with a reduced oxidative damage characterized not only by a lack of changes in glutathione reductase activity and glutathione levels but also by an absence of up-regulation of tumor necrosis factor-alpha production in intestinal mucosa.
Regulation (changes) of glutathione reductase associated with necrosis, toxicity and cancer
1) Confidence 0.22 Published 2002 Journal Dig. Dis. Sci. Section Abstract Doc Link 11991627 Disease Relevance 0.80 Pain Relevance 0
G6PD and catalase (CAT) activities were found significantly lower than in the control, whereas glutathione peroxidase (GP) activity was significantly increased in the erythrocytes of rats the receiving drug; glutathione reductase (GR) activity was unaffected.
Neg (unaffected) Regulation (unaffected) of glutathione reductase in erythrocytes
2) Confidence 0.13 Published 2005 Journal J Enzyme Inhib Med Chem Section Abstract Doc Link 15895680 Disease Relevance 0.07 Pain Relevance 0.34
Aspirin did not affect cellular glutathione content or activity of glutathione peroxidase, glutathione reductase or endogenous catalase.
Neg (not) Regulation (affect) of glutathione reductase
3) Confidence 0.06 Published 2000 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 10807398 Disease Relevance 0.06 Pain Relevance 0

General Comments

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