INT88124

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Context Info
Confidence 0.17
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.00
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PTGER2) signal transducer activity (PTGER2)
Anatomy Link Frequency
HT-29 2
fibroblasts 2
structural cells 2
PTGER2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 11 100.00 Very High Very High Very High
aspirin 9 99.08 Very High Very High Very High
Inflammation 57 91.92 High High
Inflammatory stimuli 5 91.72 High High
addiction 1 90.56 High High
withdrawal 7 68.76 Quite High
agonist 27 5.00 Very Low Very Low Very Low
antagonist 8 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ulcers 3 100.00 Very High Very High Very High
Asthma 7 94.40 High High
Disease 24 93.68 High High
Toxicity 3 92.00 High High
INFLAMMATION 72 91.92 High High
Colon Cancer 64 88.16 High High
Apoptosis 19 79.12 Quite High
Chronic Sinusitis 24 73.28 Quite High
Nasal Polyps 24 69.36 Quite High
Stress 2 66.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In their study they monitored the effect of various concentrations of PGE2 on HT-29 proliferation 24 h or 48 h after PGE2 administration.
Regulation (effect) of Positive_regulation (concentrations) of PGE2 in HT-29
1) Confidence 0.17 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0.51 Pain Relevance 0.08
More recently, a study comparing EP receptor expression in nasal biopsies from aspirin intolerant and tolerant patients showed an up-regulation of EP1 and EP2 in structural cells from aspirin intolerant subjects [15].
Regulation (regulation) of Positive_regulation (-) of EP2 in structural cells associated with aspirin
2) Confidence 0.16 Published 2006 Journal Respir Res Section Body Doc Link PMC1481584 Disease Relevance 0.72 Pain Relevance 0.34
Increased PGE2 production, via induction of the PGE2-synthesizing enzymes mPGES-1 or COX-2, has also been reported in other cell types stimulated with TNF?
Regulation (reported) of Positive_regulation (induction) of PGE2
3) Confidence 0.02 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0.29 Pain Relevance 0.11
The effect of NSAIDs and a COX-2 specific inhibitor on Helicobacter pylori-induced PGE2 and HGF in human gastric fibroblasts.
Regulation (effect) of Positive_regulation (pylori-induced) of PGE2 in fibroblasts associated with ulcers and cinod
4) Confidence 0.01 Published 2000 Journal Aliment. Pharmacol. Ther. Section Title Doc Link 10807402 Disease Relevance 0.48 Pain Relevance 0.10

General Comments

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