INT88130

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Context Info
Confidence 0.74
First Reported 2000
Last Reported 2008
Negated 0
Speculated 3
Reported most in Abstract
Documents 13
Total Number 17
Disease Relevance 12.96
Pain Relevance 3.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Spp1) extracellular space (Spp1) extracellular region (Spp1)
cell adhesion (Spp1) cytoplasm (Spp1)
Anatomy Link Frequency
macrophage 2
spinal cords 2
blood 1
peripheral nervous system 1
ASCs 1
Spp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 114 99.88 Very High Very High Very High
Sciatic nerve 4 99.44 Very High Very High Very High
Central nervous system 3 99.00 Very High Very High Very High
Neuritis 21 97.44 Very High Very High Very High
Spinal cord 12 94.12 High High
Peripheral nervous system 1 92.48 High High
anesthesia 18 89.36 High High
cytokine 12 85.88 High High
Chronic low back pain 1 80.84 Quite High
cINOD 2 64.48 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 112 99.88 Very High Very High Very High
Hypertension 288 99.72 Very High Very High Very High
Diabetes Mellitus 290 99.68 Very High Very High Very High
Coronary Heart Disease 6 99.54 Very High Very High Very High
Adhesions 16 99.44 Very High Very High Very High
Hyperoxia 49 99.32 Very High Very High Very High
Experimental Autoimmune Neuritis 21 98.40 Very High Very High Very High
Diabetic Nephropathy 40 98.08 Very High Very High Very High
Immunization 5 96.84 Very High Very High Very High
Ureteral Obstruction 12 96.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Northern blot analysis revealed that PT cells subjected to cyclic mechanical stretch with/without prior transfection with a sense oligonucleotide exhibited increased osteopontin mRNA expression compared with unstretched cells.
Gene_expression (expression) of osteopontin mRNA
1) Confidence 0.74 Published 2000 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 10807582 Disease Relevance 0.22 Pain Relevance 0.07
Antisense oligonucleotide inhibition of angiotensinogen and ANG II type 1 receptor (AT(1)) mRNA translation in rat proximal tubules (PT) was examined to provide direct evidence for a role of the renin-angiotensin system (RAS) in upregulated osteopontin expression observed following mechanical cell stretch.
Gene_expression (expression) of osteopontin in tubules
2) Confidence 0.74 Published 2000 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 10807582 Disease Relevance 0.24 Pain Relevance 0.09
In vitro studies were performed to provide mechanistic insight into ANG II-dependent osteopontin expression following mechanical cell stretch, which putatively mimics the increased PT luminal pressure post-UUO.
Gene_expression (expression) of osteopontin associated with ureteral obstruction
3) Confidence 0.74 Published 2000 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 10807582 Disease Relevance 0.27 Pain Relevance 0.09
This study provides evidence that stretch-induced upregulation of osteopontin mRNA expression is mediated, in part, via production of ANG II.
Gene_expression (expression) of osteopontin mRNA
4) Confidence 0.74 Published 2000 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 10807582 Disease Relevance 0.07 Pain Relevance 0.05
We examined the expression of osteopontin (OPN) in the sciatic nerves of rats with experimental autoimmune neuritis (EAN), using immunohistochemistry and immunoblotting, to study its involvement in the pathogenesis of autoimmune peripheral nervous system diseases.
Spec (examined) Gene_expression (expression) of osteopontin in peripheral nervous system associated with peripheral nervous system, experimental autoimmune neuritis, sciatic nerve and neuritis
5) Confidence 0.69 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15531104 Disease Relevance 0.68 Pain Relevance 0.50
To investigate the pattern of expression of osteopontin (OPN) in tissues of the central nervous system (CNS) responding to peripheral immunological stimulation, the expression of OPN was studied in the spinal cord of rats with experimental autoimmune neuritis (EAN).
Spec (investigate) Gene_expression (expression) of osteopontin in spinal cord associated with experimental autoimmune neuritis, immunization, central nervous system, neuritis and spinal cord
6) Confidence 0.57 Published 2004 Journal J. Vet. Sci. Section Abstract Doc Link 15613811 Disease Relevance 0.55 Pain Relevance 0.60
Increased expression of osteopontin in the spinal cords of Lewis rats with experimental autoimmune neuritis.
Gene_expression (expression) of osteopontin in spinal cords associated with experimental autoimmune neuritis and neuritis
7) Confidence 0.57 Published 2004 Journal J. Vet. Sci. Section Title Doc Link 15613811 Disease Relevance 0.79 Pain Relevance 1.00
We focused on MCP-1 because the expression of osteopontin in the diabetic TGR had already been investigated by Kelly et al. [13].
Gene_expression (expression) of osteopontin associated with diabetes mellitus
8) Confidence 0.49 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1175090 Disease Relevance 1.27 Pain Relevance 0
The most prominent induction was detected for osteopontin and MCP-1.
Gene_expression (detected) of osteopontin
9) Confidence 0.42 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1175090 Disease Relevance 1.32 Pain Relevance 0
The expression of MCP-1, Osteopontin, RANTES, ICAM-1 and VCAM-1 was evaluated by real-time RT-PCR.
Gene_expression (expression) of Osteopontin
10) Confidence 0.38 Published 2005 Journal BMC Nephrol Section Abstract Doc Link PMC1175090 Disease Relevance 1.40 Pain Relevance 0.04
In our study, the effect of hypertension on MCP-1 and osteopontin expression as well as on macrophage infiltration was much more prominent than the effects of diabetes mellitus.
Gene_expression (expression) of osteopontin in macrophage associated with diabetes mellitus and hypertension
11) Confidence 0.38 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1175090 Disease Relevance 1.18 Pain Relevance 0.04
Expression of mediators regulating macrophage infiltration (MCP-1, osteopontin, RANTES) and adhesion molecules involved in macrophage infiltration (ICAM-1, VCAM-1) was investigated to further elucidate inflammatory pathways in hypertensive and diabetic renal disease: In TGR rats, renal MCP-1 and osteopontin mRNA steady state levels were increased compared to SD controls, as determined by real-time RT-PCR (figure 3A and 3B).
Spec (investigated) Gene_expression (Expression) of osteopontin in macrophage associated with inflammation, diabetes mellitus, renal disease, hypertension and adhesions
12) Confidence 0.38 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1175090 Disease Relevance 1.57 Pain Relevance 0.08
It blocked blood pressure rise by aldosterone infusion, but failed to inhibit cardiac hypertrophy, inflammatory lesions, and osteopontin gene expressions.
Gene_expression (expressions) of osteopontin in blood associated with inflammation and coronary heart disease
13) Confidence 0.25 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.82 Pain Relevance 0.13
Of note, in contrast to apocynin and tempol, N-acetylcysteine, significantly prevented aldosterone-induced cardiac hypertrophy and inflammation, and osteopontin gene expression (30).
Gene_expression (expression) of osteopontin associated with inflammation and coronary heart disease
14) Confidence 0.25 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.86 Pain Relevance 0.12
Hyperoxia increased transcript and protein levels of IL-6, MCP1, and osteopontin; rolipram inhibited the increase of these proteins.
Gene_expression (levels) of osteopontin associated with hyperoxia
15) Confidence 0.24 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2563688 Disease Relevance 1.35 Pain Relevance 0.19
SP inhibited BN formation and ALPase activity in a dose-dependent manner (10(-7) to 10(-5) M) and further suppressed mRNA expression of bone sialoprotein, osteopontin, and osteocalcin but not of type I collagen mRNA.
Gene_expression (expression) of osteopontin
16) Confidence 0.08 Published 2004 Journal J. Periodontol. Section Body Doc Link 15341355 Disease Relevance 0.07 Pain Relevance 0
In ASCs, expression of these genes and of osteopontin, collagen type I and PPAR-gamma were not significantly affected.
Gene_expression (expression) of osteopontin in ASCs
17) Confidence 0.07 Published 2007 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 17572383 Disease Relevance 0.32 Pain Relevance 0.08

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