INT88133

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Context Info
Confidence 0.66
First Reported 2000
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 10.07
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Spp1) extracellular space (Spp1) extracellular region (Spp1)
cell adhesion (Spp1) cytoplasm (Spp1)
Anatomy Link Frequency
macrophage 3
Schwann cells 1
Spp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Sciatic nerve 2 99.00 Very High Very High Very High
Inflammation 99 98.34 Very High Very High Very High
Neuritis 5 96.68 Very High Very High Very High
chemokine 39 95.96 Very High Very High Very High
cytokine 12 87.20 High High
Peripheral nervous system 1 87.12 High High
cINOD 2 65.80 Quite High
anesthesia 11 45.72 Quite Low
Central nervous system 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperoxia 49 99.98 Very High Very High Very High
Hypertension 260 99.84 Very High Very High Very High
Renal Disease 5 99.38 Very High Very High Very High
Diabetes Mellitus 290 99.26 Very High Very High Very High
Diabetic Nephropathy 40 98.64 Very High Very High Very High
INFLAMMATION 97 98.34 Very High Very High Very High
Experimental Autoimmune Neuritis 5 97.64 Very High Very High Very High
Targeted Disruption 22 97.04 Very High Very High Very High
Hydronephrosis 1 96.12 Very High Very High Very High
Adhesions 16 96.06 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results lend insight into upregulation of osteopontin via a local PT RAS leading to macrophage infiltration in the tubulointerstitium in experimental hydronephrosis.
Positive_regulation (upregulation) of osteopontin in macrophage associated with hydronephrosis
1) Confidence 0.66 Published 2000 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 10807582 Disease Relevance 0.16 Pain Relevance 0
Upregulation of osteopontin in Schwann cells of the sciatic nerves of Lewis rats with experimental autoimmune neuritis.
Positive_regulation (Upregulation) of osteopontin in Schwann cells associated with experimental autoimmune neuritis, sciatic nerve and neuritis
2) Confidence 0.61 Published 2004 Journal Neurosci. Lett. Section Title Doc Link 15531104 Disease Relevance 0.88 Pain Relevance 0.66
STZ-induced diabetes mellitus of five weeks did not significantly increase MCP-1 and osteopontin mRNA in SD rats and did not augment the upregulation of MCP-1 mRNA in TGR (figure 3).
Neg (not) Positive_regulation (increase) of osteopontin associated with diabetes mellitus
3) Confidence 0.44 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1175090 Disease Relevance 1.12 Pain Relevance 0.09
Kelly et al. described that induction of osteopontin is related to macrophage infiltration in streptozotocin diabetic, mRen-2 transgenic hypertensive rats [13].
Positive_regulation (induction) of osteopontin in macrophage associated with targeted disruption, diabetes mellitus and hypertension
4) Confidence 0.44 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1175090 Disease Relevance 1.82 Pain Relevance 0.24
Gene expression of ICAM-1, VCAM-1 and RANTES was unaltered whereas Osteopontin and MCP-1 were induced by hypertension.
Positive_regulation (induced) of Osteopontin associated with hypertension
5) Confidence 0.29 Published 2005 Journal BMC Nephrol Section Abstract Doc Link PMC1175090 Disease Relevance 2.02 Pain Relevance 0.06
The most prominent induction was detected for osteopontin and MCP-1.
Positive_regulation (induction) of osteopontin
6) Confidence 0.29 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1175090 Disease Relevance 1.32 Pain Relevance 0
Expression of mediators regulating macrophage infiltration (MCP-1, osteopontin, RANTES) and adhesion molecules involved in macrophage infiltration (ICAM-1, VCAM-1) was investigated to further elucidate inflammatory pathways in hypertensive and diabetic renal disease: In TGR rats, renal MCP-1 and osteopontin mRNA steady state levels were increased compared to SD controls, as determined by real-time RT-PCR (figure 3A and 3B).
Positive_regulation (increased) of osteopontin in macrophage associated with inflammation, diabetes mellitus, renal disease, hypertension and adhesions
7) Confidence 0.29 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1175090 Disease Relevance 1.37 Pain Relevance 0.09
Hyperoxia increased transcript and protein levels of IL-6, MCP1, and osteopontin; rolipram inhibited the increase of these proteins.
Positive_regulation (increased) of osteopontin associated with hyperoxia
8) Confidence 0.19 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2563688 Disease Relevance 1.36 Pain Relevance 0.19

General Comments

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