INT88136

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.66
First Reported 2000
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 4.50
Pain Relevance 1.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Spp1) extracellular space (Spp1) extracellular region (Spp1)
cell adhesion (Spp1) cytoplasm (Spp1)
Anatomy Link Frequency
tubules 3
spinal cords 2
proximal 1
Spp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuritis 8 97.44 Very High Very High Very High
Central nervous system 2 93.84 High High
anesthesia 7 89.36 High High
Spinal cord 6 88.96 High High
cytokine 12 87.20 High High
Sciatic nerve 1 85.32 High High
Inflammation 47 75.68 Quite High
cINOD 2 65.80 Quite High
chemokine 11 25.52 Quite Low
fibrosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperoxia 49 99.98 Very High Very High Very High
Diabetic Nephropathy 8 98.64 Very High Very High Very High
Experimental Autoimmune Neuritis 8 98.40 Very High Very High Very High
Hypertension 52 97.40 Very High Very High Very High
Ureteral Obstruction 15 96.04 Very High Very High Very High
Diabetes Mellitus 58 93.84 High High
Immunization 1 91.68 High High
Weight Gain 12 90.48 High High
Pneumonia 5 76.08 Quite High
Toxicity 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vitro studies were performed to provide mechanistic insight into ANG II-dependent osteopontin expression following mechanical cell stretch, which putatively mimics the increased PT luminal pressure post-UUO.
Positive_regulation (dependent) of Gene_expression (expression) of osteopontin associated with ureteral obstruction
1) Confidence 0.66 Published 2000 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 10807582 Disease Relevance 0.27 Pain Relevance 0.09
Northern blot analysis revealed that PT cells subjected to cyclic mechanical stretch with/without prior transfection with a sense oligonucleotide exhibited increased osteopontin mRNA expression compared with unstretched cells.
Positive_regulation (increased) of Gene_expression (expression) of osteopontin mRNA
2) Confidence 0.66 Published 2000 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 10807582 Disease Relevance 0.22 Pain Relevance 0.07
Antisense oligonucleotide inhibition of angiotensinogen and ANG II type 1 receptor (AT(1)) mRNA translation in rat proximal tubules (PT) was examined to provide direct evidence for a role of the renin-angiotensin system (RAS) in upregulated osteopontin expression observed following mechanical cell stretch.
Positive_regulation (upregulated) of Gene_expression (expression) of osteopontin in tubules
3) Confidence 0.66 Published 2000 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 10807582 Disease Relevance 0.24 Pain Relevance 0.09
This study provides evidence that stretch-induced upregulation of osteopontin mRNA expression is mediated, in part, via production of ANG II.
Positive_regulation (upregulation) of Gene_expression (expression) of osteopontin mRNA
4) Confidence 0.66 Published 2000 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 10807582 Disease Relevance 0.07 Pain Relevance 0.05
Increased expression of osteopontin in the spinal cords of Lewis rats with experimental autoimmune neuritis.
Positive_regulation (Increased) of Gene_expression (expression) of osteopontin in spinal cords associated with experimental autoimmune neuritis and neuritis
5) Confidence 0.51 Published 2004 Journal J. Vet. Sci. Section Title Doc Link 15613811 Disease Relevance 0.79 Pain Relevance 1.00
Antisense oligonucleotide inhibition of angiotensinogen and ANG II type 1 receptor (AT(1)) mRNA translation in rat proximal tubules (PT) was examined to provide direct evidence for a role of the renin-angiotensin system (RAS) in upregulated osteopontin expression observed following mechanical cell stretch.
Positive_regulation (role) of in proximal Gene_expression (expression) of osteopontin in tubules
6) Confidence 0.48 Published 2000 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 10807582 Disease Relevance 0.24 Pain Relevance 0.09
The most prominent induction was detected for osteopontin and MCP-1.
Positive_regulation (induction) of Gene_expression (detected) of osteopontin
7) Confidence 0.32 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1175090 Disease Relevance 1.32 Pain Relevance 0
Hyperoxia increased transcript and protein levels of IL-6, MCP1, and osteopontin; rolipram inhibited the increase of these proteins.
Positive_regulation (increased) of Gene_expression (levels) of osteopontin associated with hyperoxia
8) Confidence 0.19 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2563688 Disease Relevance 1.36 Pain Relevance 0.19

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox