INT88145

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.42
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 5.31
Pain Relevance 2.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il5) extracellular region (Il5)
Anatomy Link Frequency
parenchyma 4
lung 2
eosinophil 2
Il5 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 221 100.00 Very High Very High Very High
cytokine 121 100.00 Very High Very High Very High
agonist 18 99.60 Very High Very High Very High
qutenza 10 99.44 Very High Very High Very High
Potency 7 88.52 High High
chemokine 6 83.40 Quite High
Inflammatory mediators 2 81.12 Quite High
dexamethasone 16 77.36 Quite High
cINOD 8 77.08 Quite High
Inflammatory response 19 58.12 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 234 100.00 Very High Very High Very High
Eosinophilia 17 99.76 Very High Very High Very High
Hypersensitivity 116 98.68 Very High Very High Very High
Pneumonia 16 98.64 Very High Very High Very High
Rheumatoid Arthritis 37 95.44 Very High Very High Very High
Disease 76 95.16 Very High Very High Very High
Asthma 167 94.72 High High
Multiple Sclerosis 18 89.20 High High
Infection 1 88.72 High High
Urological Neuroanatomy 12 79.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We observed that although the accumulation of lymphocytes in the airways of PPNK-deficient mice was similar to that induced in control mice, IL-5 production and eosinophil infiltration were reduced.
Negative_regulation (reduced) of Gene_expression (production) of IL-5 in eosinophil
1) Confidence 0.42 Published 2000 Journal J. Neuroimmunol. Section Abstract Doc Link 10808051 Disease Relevance 0.43 Pain Relevance 0.04
agonists have been shown to reduce IL4, IL5, and IL13 production from Tcells of mice with induced lung inflammation [38,49].
Negative_regulation (reduce) of Gene_expression (production) of IL5 in lung associated with inflammation, agonist and pneumonia
2) Confidence 0.41 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC1781426 Disease Relevance 0.52 Pain Relevance 0.36
Treatment with highest dose of retinoic acid abolished airway hyperresponsiveness and downregulated expression of IL-5
Negative_regulation (abolished) of Gene_expression (expression) of IL-5
3) Confidence 0.36 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2773769 Disease Relevance 0 Pain Relevance 0
In concordance with results of airway eosinophilia, levels of IL-5 expression in parenchyma cells and lung function were also abolished by treatment with highest doses of retinoic acid.
Negative_regulation (abolished) of Gene_expression (expression) of IL-5 in parenchyma associated with eosinophilia
4) Confidence 0.36 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2773769 Disease Relevance 0.38 Pain Relevance 0.03
on IL-4, IL-5, IL-10, and IL-13 production may have involved reduced production of IL-4, IL-5, IL-13,
Negative_regulation (reduced) of Gene_expression (production) of IL-5
5) Confidence 0.30 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.20 Pain Relevance 0.04
Similarly, a significant inhibition of allergen-induced interleukin-5 production on day 1 and eosinophilia on day 2 was observed at a dose of 0.3 mg/kg of budesonide in females only.
Negative_regulation (inhibition) of Gene_expression (production) of interleukin-5 associated with eosinophilia
6) Confidence 0.28 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC406499 Disease Relevance 0.89 Pain Relevance 0.40
Treatment with highest dose of retinoic acid abolished airway hyperresponsiveness and downregulated expression of IL-5
Negative_regulation (downregulated) of Gene_expression (expression) of IL-5
7) Confidence 0.27 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2773769 Disease Relevance 0 Pain Relevance 0
In quantitative analysis of IL-5, using the Light Cycler quantitative PCR system (Roche, Mannheim, Germany), results shows that there is a significant reduction of IL-5 expression in lung parenchyma of non-treated allergic mice compared to mice treated with the highest dose of ATRA every second day.


Negative_regulation (reduction) of Gene_expression (expression) of IL-5 in parenchyma associated with hypersensitivity
8) Confidence 0.27 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2773769 Disease Relevance 0.23 Pain Relevance 0
Thus, the overall pattern of results for cellular infiltration and the levels of the pro-inflammatory cytokines, IL-4, IL-5 and TNF-?
Negative_regulation (levels) of Gene_expression (levels) of IL-5 associated with inflammation and cytokine
9) Confidence 0.22 Published 2004 Journal Respir Res Section Body Doc Link PMC419478 Disease Relevance 1.13 Pain Relevance 0.72
Asshown in Figure 7, IL-4, IL-5, IL-13, IgE productions in
Negative_regulation (Asshown) of Gene_expression (productions) of IL-5
10) Confidence 0.22 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.23 Pain Relevance 0.13
Direct administration of capsicum extract (1 and 10 mug/ml) and capsaicin (3 and 30 muM) resulted in suppression of interleukin (IL)-2, interferon (IFN)-gamma, IL-4 and IL-5 production.
Negative_regulation (suppression) of Gene_expression (production) of IL-5 associated with qutenza
11) Confidence 0.21 Published 2007 Journal Life Sci. Section Abstract Doc Link 17306834 Disease Relevance 0 Pain Relevance 0.42
In BALF, the levels of a Th2 cytokines, including IL-4, IL-5, and IL-13 were significantly decreased in the sTNFR treated group compared with the OVA group (96.01 ± 16.08 vs. 50.67 ± 7.79*, 223.6 ± 40.3 vs. 136.6 ± 21.7*, 203.3 ± 20.1 vs. 116.6 ± 15.5**, respectively ; *p < 0.05, **p < 0.01) (Figs. 2A, B and C).
Negative_regulation (decreased) of Gene_expression (levels) of IL-5 associated with cytokine
12) Confidence 0.19 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2730622 Disease Relevance 0.18 Pain Relevance 0.16
These authors showed that the treatment with lupeol reduced levels of IL-4, IL-5 and IL-13, characteristic of an allergic airway inflammatory process.
Negative_regulation (reduced) of Gene_expression (levels) of IL-5 associated with inflammation and hypersensitivity
13) Confidence 0.06 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC3019217 Disease Relevance 1.13 Pain Relevance 0.40

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox