INT88156

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Context Info
Confidence 0.54
First Reported 2000
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 2.50
Pain Relevance 4.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gria1) transport (Gria1) endoplasmic reticulum (Gria1)
plasma membrane (Gria1) protein complex (Gria1)
Anatomy Link Frequency
spinal cord 1
brain 1
lamina 1
synapses 1
hippocampus 1
Gria1 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 42 100.00 Very High Very High Very High
antagonist 5 99.96 Very High Very High Very High
Pain 15 99.48 Very High Very High Very High
Dorsal horn 52 99.20 Very High Very High Very High
long-term potentiation 113 99.18 Very High Very High Very High
Somatosensory cortex 12 98.88 Very High Very High Very High
antinociception 1 98.64 Very High Very High Very High
Hippocampus 43 98.54 Very High Very High Very High
Anterior cingulate cortex 82 97.88 Very High Very High Very High
Opioid 2 97.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypersensitivity 9 98.88 Very High Very High Very High
Anxiety Disorder 55 98.56 Very High Very High Very High
Pain 33 98.16 Very High Very High Very High
Inflammatory Pain 7 95.28 Very High Very High Very High
Targeted Disruption 65 91.60 High High
Vomiting 4 90.56 High High
Congenital Anomalies 4 80.08 Quite High
Cognitive Disorder 9 75.52 Quite High
Shock 8 74.48 Quite High
Sprains And Strains 15 73.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been shown that AMPA-receptor phosphorylation is critical for synaptic plasticity in the brain [61] and postsynaptically, GluR1 is mainly regulated through changes in CaMKII phosphorylation [62].
Regulation (regulated) of GluR1 in brain
1) Confidence 0.54 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0.07 Pain Relevance 0.18
These results suggest that the GluA1 and GluA2 subunits differently modulate synaptic plasticity in the SSC, consistent with the ACC.


Regulation (modulate) of GluA1 associated with somatosensory cortex and anterior cingulate cortex
2) Confidence 0.45 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734546 Disease Relevance 0.38 Pain Relevance 0.59
There is strong evidence of a critical role for GluR1-containing AMPA receptors in the formation of fear memories using the Pavlovian conditioning paradigm (Hu et al., 2007; Rumpel et al., 2005; Yeh et al., 2006).
Regulation (role) of GluR1-containing associated with anxiety disorder
3) Confidence 0.44 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525858 Disease Relevance 0.63 Pain Relevance 0.17
Zhou et al. [51] observed a rapid up-regulation of GluR1 mRNA in the lumbar dorsal horn following injection of complete Freund's adjuvant into the hindpaw, while Fang et al. [52] reported phosphorylation of this subunit at both S831 and S845 sites in Western blots of spinal cord tissue after intradermal capsaicin injection.
Regulation (regulation) of GluR1 in spinal cord associated with qutenza, dorsal horn and spinal cord
4) Confidence 0.39 Published 2008 Journal Mol Pain Section Body Doc Link PMC2248168 Disease Relevance 0.10 Pain Relevance 0.55
Because no changes were observed in total hippocampus homogenate, the specific decrease in the PSD is therefore attributed to changes in glutamate receptor subunit trafficking or clustering in the PSD instead of a reduced protein translation.
Regulation (changes) of glutamate receptor in hippocampus associated with glutamate receptor and hippocampus
5) Confidence 0.31 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1892123 Disease Relevance 0.22 Pain Relevance 0.33
Activity-dependent insertion of AMPArs that contain either GluR1 or GluR4 is thought to underlie certain forms of LTP, and it is therefore likely that either GluR1- or GluR4-containing receptors are responsible for this phenomenon in lamina I projection cells.


Regulation (responsible) of GluR1 in lamina associated with long-term potentiation
6) Confidence 0.20 Published 2008 Journal Mol Pain Section Body Doc Link PMC2248168 Disease Relevance 0 Pain Relevance 0.32
Differential potentiative effects of glutamate receptor antagonists in the production of antinociception induced by opioids administered intrathecally in the mouse.
Regulation (effects) of glutamate receptor associated with pain, antinociception, antagonist, glutamate receptor and opioid
7) Confidence 0.18 Published 2000 Journal Brain Res. Bull. Section Title Doc Link 10808085 Disease Relevance 0 Pain Relevance 1.13
GluR1 immunoreactivity is decreased in Shank3 heterozygous mice
Regulation (immunoreactivity) of GluR1
8) Confidence 0.17 Published 2010 Journal Mol Autism Section Body Doc Link PMC3019144 Disease Relevance 0.16 Pain Relevance 0.06
1 promoter-driven Cre expression does not exactly follow the expression pattern of GluR?
Neg (not) Regulation (follow) of GluR
9) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615205 Disease Relevance 0.07 Pain Relevance 0.09
GluR1 subunit was up-regulated 1.3 fold and 2 fold in Tg20 and Prnp ?
Regulation (ted) of GluR1
10) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2763346 Disease Relevance 0.12 Pain Relevance 0.24
One of them, the anti-Parkinson drug Amantadine, shares the NMDA glutamate receptor as a target with Memantine (Figure 3c).
Regulation (target) of glutamate receptor associated with glutamate receptor
11) Confidence 0.05 Published 2011 Journal Nucleic Acids Research Section Body Doc Link PMC3013657 Disease Relevance 0.47 Pain Relevance 0.25
In addition, among the putative CaRF target genes that are related to calcium signaling, the proteins encoded by Caly (Calcyon) and Cacng2 (Stargazin) contribute to the regulation of AMPA-type glutamate receptor trafficking to synapses [35], [36] suggesting a possible mechanism by which CaRF-dependent transcription could modulate the strength of excitatory synapses.
Regulation (regulation) of glutamate receptor in synapses associated with glutamate receptor
12) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877716 Disease Relevance 0.29 Pain Relevance 0.13

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