INT88173

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Context Info
Confidence 0.79
First Reported 2000
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.89
Pain Relevance 2.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SGCG) cytoskeleton (SGCG) cytoskeleton organization (SGCG)
cytoplasm (SGCG)
Anatomy Link Frequency
dentin 1
SGCG (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 14 98.20 Very High Very High Very High
opioid receptor 5 97.48 Very High Very High Very High
Calcium channel 7 94.64 High High
Opioid 3 87.64 High High
tolerance 2 81.28 Quite High
Potency 1 79.16 Quite High
Antinociceptive 1 78.84 Quite High
conotoxin 1 78.00 Quite High
Pain 1 71.36 Quite High
Disease Link Frequency Relevance Heat
Dentin Dysplasia 7 100.00 Very High Very High Very High
Disease 1 83.84 Quite High
Glioma 2 76.00 Quite High
Pain 1 71.36 Quite High
Cleidocranial Dysplasia 1 63.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The L-type channel Ca(v)1.3 protein, but not the Ca(v)1.2 protein or phosphorylation state, significantly decreased upon chronic morphine treatment.
Phosphorylation (phosphorylation) of type associated with morphine
1) Confidence 0.79 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18048029 Disease Relevance 0 Pain Relevance 0.94
These results suggest that morphine may trigger independent reaction pathways affecting either transcription regulation and/or postsynthetic phosphorylation of the preexisting HMG I-type proteins.
Phosphorylation (phosphorylation) of type associated with morphine
2) Confidence 0.61 Published 2000 Journal Life Sci. Section Abstract Doc Link 10809169 Disease Relevance 0.15 Pain Relevance 0.33
These molecular changes include the up-regulation and augmented phosphorylation of adenylyl cyclase type II isoforms, which underlies the ability of morphine to shift opioid receptor G protein signalling from predominantly Gialpha inhibitory to Gbetagamma stimulatory.
Phosphorylation (phosphorylation) of type associated with opioid receptor and morphine
3) Confidence 0.61 Published 2004 Journal Novartis Found. Symp. Section Abstract Doc Link 15469050 Disease Relevance 0 Pain Relevance 0.71
Four distinct forms of dentin dysplasia type I and 1 form of dentin dysplasia type II are identified.
Phosphorylation (form) of type in dentin associated with dentin dysplasia
4) Confidence 0.40 Published 2009 Journal Quintessence Int Section Abstract Doc Link 19417880 Disease Relevance 0.74 Pain Relevance 0.07

General Comments

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