INT88177

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Context Info
Confidence 0.25
First Reported 2000
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.51
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ido1) oxidoreductase activity (Ido1) cytoplasm (Ido1)
Anatomy Link Frequency
blood 1
microglia 1
Ido1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 2 97.04 Very High Very High Very High
antidepressant 2 92.80 High High
antagonist 1 92.60 High High
cINOD 2 89.04 High High
depression 7 86.44 High High
COX-2 inhibitor 3 80.36 Quite High
agonist 6 80.16 Quite High
nMDA receptor 2 79.84 Quite High
Central nervous system 1 75.44 Quite High
Serotonin 3 75.00 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 4 88.64 High High
Depression 8 86.44 High High
Necrosis 1 45.28 Quite Low
Cancer 1 44.92 Quite Low
Toothache 3 5.00 Very Low Very Low Very Low
Infection 3 5.00 Very Low Very Low Very Low
Hypertension 2 5.00 Very Low Very Low Very Low
Fibrosis 1 5.00 Very Low Very Low Very Low
Weight Loss 1 5.00 Very Low Very Low Very Low
Hypesthesia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Medullary blood flow (MBF) decreased after INDO (18%; p<0.05), and dose-dependently after MELO (1 mg, 10%; 2 mg, 18%; p<0.05).
Negative_regulation (decreased) of INDO in blood
1) Confidence 0.25 Published 2000 Journal Exp. Nephrol. Section Abstract Doc Link 10810234 Disease Relevance 0.07 Pain Relevance 0.22
The reduced number of astrocytes could contribute to both, a diminished counterregulation of IDO activity in microglia and an altered glutamatergic neurotransmission.
Negative_regulation (counterregulation) of IDO in microglia
2) Confidence 0.25 Published 2007 Journal Mol. Psychiatry Section Abstract Doc Link 17457312 Disease Relevance 0.44 Pain Relevance 0.76
Interestingly, the vasorelaxations were abolished by all the tested extracts and by the ACh in the presence of l-NAME (1 mM) plus INDO (1 mM), but no significant change was noted in the case of SNP.
Negative_regulation (abolished) of INDO
3) Confidence 0.17 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635640 Disease Relevance 0 Pain Relevance 0.05

General Comments

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