INT88179

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Context Info
Confidence 0.41
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.96
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (FOS) aging (FOS) nucleolus (FOS)
nucleus (FOS)
FOS (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 1 95.84 Very High Very High Very High
metalloproteinase 113 94.96 High High
Central nervous system 1 90.92 High High
Enkephalin 2 79.88 Quite High
Opioid 3 78.68 Quite High
Delta opioid receptors 1 75.52 Quite High
Hippocampus 4 40.64 Quite Low
Inflammation 10 12.88 Low Low
Bioavailability 4 5.00 Very Low Very Low Very Low
Glutamate 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 27 100.00 Very High Very High Very High
Necrosis 3 100.00 Very High Very High Very High
Cv Unclassified Under Development 1 95.84 Very High Very High Very High
Middle Cerebral Artery Infarction 1 92.40 High High
Death 3 86.64 High High
Wound Healing 4 72.16 Quite High
Pathologic Processes 2 59.52 Quite High
Metastasis 12 57.28 Quite High
Wrinkles 6 56.08 Quite High
Fibrosarcoma 8 44.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DADLE acted against this effect of METH at least in part by attenuating the mRNA expressions of a tumor necrosis factor p53 and an immediate early gene c-fos.
Negative_regulation (attenuating) of Transcription (expressions) of c-fos associated with necrosis and cancer
1) Confidence 0.41 Published 2000 Journal J. Biomed. Sci. Section Abstract Doc Link 10810237 Disease Relevance 0.47 Pain Relevance 0.56
Fifteen days after the lesion of the AC, the number of c-Fos Ir nuclei was 36% lower that in controls and 90?
Negative_regulation (lower) of Transcription (number) of c-Fos
2) Confidence 0.41 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2981384 Disease Relevance 0 Pain Relevance 0
As per their investigations, CM-chitin exhibited a higher MMP inhibitory, (MMP-2 and MMP-9) effect than CM-chitosan through transcriptional downregulations of activator protein-1 (AP-1) and nuclear factor ?
Negative_regulation (downregulations) of Transcription (transcriptional) of activator protein-1
3) Confidence 0.05 Published 2010 Journal Biochemistry Research International Section Body Doc Link PMC3004377 Disease Relevance 0.24 Pain Relevance 0.11
As per their investigations, CM-chitin exhibited a higher MMP inhibitory, (MMP-2 and MMP-9) effect than CM-chitosan through transcriptional downregulations of activator protein-1 (AP-1) and nuclear factor ?
Negative_regulation (downregulations) of Transcription (transcriptional) of AP-1
4) Confidence 0.05 Published 2010 Journal Biochemistry Research International Section Body Doc Link PMC3004377 Disease Relevance 0.25 Pain Relevance 0.11

General Comments

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