INT88182

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Context Info
Confidence 0.78
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 40
Total Number 42
Disease Relevance 22.91
Pain Relevance 4.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex (Atp2a2)
Anatomy Link Frequency
heart 5
reticulum 3
dorsal horn 2
cardiomyocytes 1
muscle 1
Atp2a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Action potential 75 99.74 Very High Very High Very High
tetrodotoxin 21 99.50 Very High Very High Very High
action potential duration 48 98.72 Very High Very High Very High
Calcium channel 29 97.68 Very High Very High Very High
Dorsal horn 8 97.60 Very High Very High Very High
fibrosis 79 96.56 Very High Very High Very High
qutenza 43 95.76 Very High Very High Very High
opiate 10 95.24 Very High Very High Very High
ischemia 157 93.12 High High
unmyelinated 1 89.12 High High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 1544 99.84 Very High Very High Very High
Diabetic Cardiomyopathies 629 99.76 Very High Very High Very High
Hypoxia 1094 99.56 Very High Very High Very High
Coronary Heart Disease 117 99.08 Very High Very High Very High
Myocardial Infarction 582 98.90 Very High Very High Very High
Injury 141 98.80 Very High Very High Very High
Cardiomyopathy 85 98.32 Very High Very High Very High
Stress 201 98.20 Very High Very High Very High
Body Weight 50 97.56 Very High Very High Very High
Cardiovascular Disorder Under Development 68 97.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Denervation or TTX treatment prevented the expression of the SERCA2 isoform.
Gene_expression (expression) of SERCA2 isoform associated with tetrodotoxin
1) Confidence 0.78 Published 2002 Journal Exp. Physiol. Section Abstract Doc Link 12481932 Disease Relevance 0 Pain Relevance 0.25
These data indicate that nerve impulses play a determinant role in the expression of the SERCA2 isoform.
Gene_expression (expression) of SERCA2 isoform in nerve
2) Confidence 0.78 Published 2002 Journal Exp. Physiol. Section Abstract Doc Link 12481932 Disease Relevance 0 Pain Relevance 0.23
The overexpression of SERCA2a in diseased hearts has been shown to result in the recovery of contractility [23], [24], [25] and in improved survival, corresponding with an improvement in energy consumption [26].
Gene_expression (overexpression) of SERCA2a in hearts
3) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827566 Disease Relevance 0.33 Pain Relevance 0.15
Furthermore, SERCA overexpression decreases or prevents cardiac hypertrophy [27], [28], [29].
Gene_expression (overexpression) of SERCA associated with coronary heart disease
4) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827566 Disease Relevance 0.28 Pain Relevance 0.13
New results are presented showing suboptimal Ca(2+) concentration in the ER lumen in association with reduced SERCA2 expression in sensory neurones from type 1 diabetic rats.
Gene_expression (expression) of SERCA2 in lumen associated with diabetes mellitus
5) Confidence 0.69 Published 2008 Journal Cell Calcium Section Abstract Doc Link 18191198 Disease Relevance 1.25 Pain Relevance 0.06
Conversely, vinblastine did not affect the expression of SERCA isoforms.
Gene_expression (expression) of SERCA
6) Confidence 0.68 Published 2002 Journal Exp. Physiol. Section Abstract Doc Link 12481932 Disease Relevance 0 Pain Relevance 0.24
Expression of SERCA isoforms was visualized by immunohistochemical and Western blot analysis.
Gene_expression (Expression) of SERCA
7) Confidence 0.68 Published 2002 Journal Exp. Physiol. Section Abstract Doc Link 12481932 Disease Relevance 0 Pain Relevance 0.26
Expression of sarco(endo)plasmic reticulum Ca(2+)-ATPase slow (SERCA2) isoform in regenerating rat soleus skeletal muscle depends on nerve impulses.
Gene_expression (Expression) of SERCA2 in soleus
8) Confidence 0.68 Published 2002 Journal Exp. Physiol. Section Title Doc Link 12481932 Disease Relevance 0 Pain Relevance 0.21
We have examined the influence of innervation on the expression of different isoforms of sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA) in regenerating rat slow twitch muscle.
Spec (examined) Gene_expression (expression) of SERCA in muscle
9) Confidence 0.68 Published 2002 Journal Exp. Physiol. Section Abstract Doc Link 12481932 Disease Relevance 0 Pain Relevance 0.15
Resveratrol treatment to these mice had a tremendous beneficial effect both in terms of improving SERCA2 expression and cardiac function.
Gene_expression (expression) of SERCA2
10) Confidence 0.28 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2964943 Disease Relevance 1.12 Pain Relevance 0.19
As previously discussed,47 a significant role in the myocardial dysfunction of DCM is supported by the reduction of the sarcoplasmic calcium ATPase myocardial expression (SERCA2).
Gene_expression (expression) of SERCA2 associated with cardiomyopathy and diabetic cardiomyopathies
11) Confidence 0.28 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2964943 Disease Relevance 1.31 Pain Relevance 0.23
Treatment with breviscapine reversed the cardiac dysfunction and structure changes in rats with DCM, decreased the expression of PKC, and increased the expression of calcium handling regulators, ie, protein phosphatase inhibitor-1, phospholamban, and SERCA2.
Gene_expression (expression) of SERCA2 associated with diabetic cardiomyopathies
12) Confidence 0.28 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2964943 Disease Relevance 1.26 Pain Relevance 0.04
Decreased SERCA2a expression should alter the balance of Ca2+ homeostasis in favor of increased Ca2+ extrusion via NCX and might be expected to reduce SR Ca2+ content.
Gene_expression (expression) of SERCA2a
13) Confidence 0.26 Published 2008 Journal Diabetes Section Body Doc Link PMC2494698 Disease Relevance 0.57 Pain Relevance 0.04
The reduction in the level of expression of SERCA2a (?
Gene_expression (expression) of SERCA2a
14) Confidence 0.26 Published 2008 Journal Diabetes Section Body Doc Link PMC2494698 Disease Relevance 0.33 Pain Relevance 0.05
The slower action potential and reduced SERCA2a expression can explain the slower Ca2+ transient kinetics in diabetic rats but not the contractile deficit.
Gene_expression (expression) of SERCA2a associated with action potential and diabetes mellitus
15) Confidence 0.26 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2494698 Disease Relevance 0.83 Pain Relevance 0.09
Although we found almost no effects on peak Ca2+ in a variety of conditions, the finding that there was a reduced rate of SR Ca2+ uptake and SERCA2a expression was surprising, since these changes might be expected to decrease SR Ca2+ content (and therefore the amplitude of the Ca2+ transient).
Gene_expression (expression) of SERCA2a
16) Confidence 0.26 Published 2008 Journal Diabetes Section Body Doc Link PMC2494698 Disease Relevance 0.21 Pain Relevance 0.08
The latter explanation seems likely because we found decreased levels of SERCA2a expression in the diabetic rat.
Gene_expression (expression) of SERCA2a associated with diabetes mellitus
17) Confidence 0.26 Published 2008 Journal Diabetes Section Body Doc Link PMC2494698 Disease Relevance 0.58 Pain Relevance 0.04
Figure 4 shows Western blots of SERCA2a and NCX protein expression.
Gene_expression (expression) of SERCA2a
18) Confidence 0.26 Published 2008 Journal Diabetes Section Body Doc Link PMC2494698 Disease Relevance 0.74 Pain Relevance 0
Anoxia also reduced both sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) activity and Ca2+ extrusion [probably via plasma membrane Ca2+-ATPase (PMCA)].
Gene_expression (extrusion) of SERCA in reticulum associated with hypoxia
19) Confidence 0.23 Published 2008 Journal Journal of Neurophysiology Section Abstract Doc Link PMC2493471 Disease Relevance 0.76 Pain Relevance 0.09
The data demonstrate that in DCM, where the expression of SERCA2 is reduced, resveratrol enhances the expression of the SERCA2 and improves cardiac function.169
Gene_expression (expression) of SERCA2 associated with diabetic cardiomyopathies
20) Confidence 0.22 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2964943 Disease Relevance 1.16 Pain Relevance 0.19

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