INT88183

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Context Info
Confidence 0.63
First Reported 2000
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 9
Disease Relevance 2.10
Pain Relevance 2.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex (Atp2a2)
Anatomy Link Frequency
spinal cord 2
dorsal root 1
CPA 1
dorsal horn 1
Atp2a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 32 100.00 Very High Very High Very High
Spinal cord 9 99.36 Very High Very High Very High
Dorsal horn 8 98.92 Very High Very High Very High
opiate 5 98.56 Very High Very High Very High
Inflammation 4 89.12 High High
ischemia 64 80.24 Quite High
spinal dorsal horn 4 75.00 Quite High
Dorsal horn neuron 1 75.00 Quite High
substantia gelatinosa 4 72.48 Quite High
depression 1 61.76 Quite High
Disease Link Frequency Relevance Heat
Nociception 16 98.84 Very High Very High Very High
Hypoxia 584 97.32 Very High Very High Very High
Cv Unclassified Under Development 56 80.24 Quite High
Depression 1 61.76 Quite High
Alkalosis 8 48.00 Quite Low
Acidosis 12 11.68 Low Low
Coronary Artery Disease 8 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 8 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Exsanguination 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Antibody coated microprobes, inserted into the spinal cord at the L4-5 level, were used to detect whether endomorphin-2 (Endo2) was released from spinal dorsal horns in anesthetized rats in response to formalin injected into the hindpaw footpads.
Localization (released) of Endo2 in spinal cord associated with spinal cord
1) Confidence 0.63 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12431774 Disease Relevance 0.08 Pain Relevance 0.37
Formalin injections caused an increase in Fos expression as well as a release of SP, but not Endo2 from the ipsilateral side dorsal horn in L4-5.
Localization (release) of Endo2 in dorsal horn associated with dorsal horn and substance p
2) Confidence 0.55 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12431774 Disease Relevance 0.09 Pain Relevance 0.45
SP but not Endo2 was released during pre-stimulation periods.
Localization (released) of Endo2 associated with substance p
3) Confidence 0.55 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12431774 Disease Relevance 0.10 Pain Relevance 0.44
Saline injections did not cause the release of either Endo2 or SP from the spinal cord.
Localization (release) of Endo2 in spinal cord associated with spinal cord and substance p
4) Confidence 0.48 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12431774 Disease Relevance 0.10 Pain Relevance 0.45
To estimate Ca2+ clearance by SERCA, we subtracted Ca2+ clearance rates measured in the presence of CPA or thapsigargin from total cytosolic Ca2+ clearance rates measured in the absence of CPA or thapsigargin (see Fig. 14).
Localization (clearance) of SERCA in CPA
5) Confidence 0.22 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.60 Pain Relevance 0
15 min in anoxic aglycemia), profound disturbance of Ca2+ homeostasis with near complete failure of Ca2+ clearance by both SERCA and PMCA and complete depletion of the ER Ca2+ stores.
Localization (clearance) of SERCA
6) Confidence 0.22 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.21 Pain Relevance 0.04
Under conditions of anoxic aglycemia, there was a biphasic and more profound elevation of [Ca2+]i, which was associated with complete ER Ca2+ store emptying and progressive, and eventually complete, inhibition of Ca2+ clearance by PMCA and SERCA.
Localization (clearance) of SERCA
7) Confidence 0.22 Published 2008 Journal Journal of Neurophysiology Section Abstract Doc Link PMC2493471 Disease Relevance 0.49 Pain Relevance 0
While this could be due to a direct inhibition of mitochondrial Ca2+ release, it is also possible that it is simply an indirect consequence of reduced cytosolic Ca2+ clearance via PMCA and SERCA.
Localization (clearance) of SERCA
8) Confidence 0.22 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.37 Pain Relevance 0
Second, release of immunoreactive Endo-2-like substances (irEndo) from the in vitro rat spinal cords upon electrical stimulation of dorsal root afferent fibers was detected by the immobilized antibody microprobe technique.
Localization (release) of Endo-2 in dorsal root
9) Confidence 0.04 Published 2000 Journal J. Biomed. Sci. Section Abstract Doc Link 10810239 Disease Relevance 0.06 Pain Relevance 0.47

General Comments

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