INT88195

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Context Info
Confidence 0.74
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 17
Disease Relevance 4.79
Pain Relevance 1.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (ZAK) cell proliferation (ZAK) cell death (ZAK)
nucleus (ZAK) cell cycle (ZAK) response to stress (ZAK)
Anatomy Link Frequency
embryos 2
Blood 1
melanocyte 1
pineal gland 1
ZAK (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 84 97.84 Very High Very High Very High
Kappa opioid receptor 1 94.52 High High
Opioid 2 93.24 High High
Inflammation 3 91.04 High High
Arthritis 3 84.20 Quite High
Inflammatory response 1 83.64 Quite High
cytokine 6 81.44 Quite High
backache 18 73.40 Quite High
agonist 84 70.04 Quite High
Dynorphin 1 69.00 Quite High
Disease Link Frequency Relevance Heat
Disease 195 98.06 Very High Very High Very High
Apoptosis 16 96.56 Very High Very High Very High
Nevus 3 93.36 High High
Skin Cancer 21 92.12 High High
INFLAMMATION 4 91.40 High High
Hematological Disease 2 90.60 High High
Fibromyalgia 6 90.04 High High
Death 33 89.92 High High
Microphthalmia 33 89.00 High High
Cancer 6 84.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The light conditions in the early morning have a strong impact on the morning cortisol peak, whereas MLT is synthesized in a strictly nocturnal pattern.
Gene_expression (synthesized) of MLT
1) Confidence 0.74 Published 2006 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 16855156 Disease Relevance 0.53 Pain Relevance 0.29
We obtained a pk of 0.86±0.022 (ROC and LOC events), notably, this was identical to the pk obtained from study I.
Gene_expression (obtained) of pk
2) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2811188 Disease Relevance 0.07 Pain Relevance 0
As is obvious from Figure 3, the pk values were strictly normal distributed for both studies (p?
Gene_expression (values) of pk
3) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2811188 Disease Relevance 0.07 Pain Relevance 0
Most interestingly, gamma-interferon and colony stimulating factors (CSFs) may modulate the production of MLT in the pineal gland.
Gene_expression (production) of MLT in pineal gland
4) Confidence 0.23 Published 1999 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 10810540 Disease Relevance 0.73 Pain Relevance 0.35
, is subject to prostacyclin and PGD2-mediated desensitization in a mechanism involving direct protein kinase (PK) A phosphorylation of TP?
Gene_expression (involving) of PK
5) Confidence 0.11 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.04
To evaluate validity, differences among the four groups (healthy, physical, mental and mixed groups) were tested for significance (P ? 
Gene_expression (groups) of mixed
6) Confidence 0.03 Published 2010 Journal J Occup Rehabil Section Body Doc Link PMC2980635 Disease Relevance 0.18 Pain Relevance 0
Table 3 (Columns 6d–f) and Fig. 1 show the differences between the physical, mental and mixed groups.
Gene_expression (groups) of mixed
7) Confidence 0.03 Published 2010 Journal J Occup Rehabil Section Body Doc Link PMC2980635 Disease Relevance 0.13 Pain Relevance 0
Self-classification and classification on the basis of disease codes results in the same classification for 75% of the respondents in the physical, mental and mixed groups, for 66% of the respondents in the mental and mixed groups, for 90% in the physical and mixed groups, and for 96% in the physical and mental groups.
Gene_expression (groups) of mixed associated with disease
8) Confidence 0.03 Published 2010 Journal J Occup Rehabil Section Body Doc Link PMC2980635 Disease Relevance 0.48 Pain Relevance 0.07
Self-classification and classification on the basis of disease codes results in the same classification for 75% of the respondents in the physical, mental and mixed groups, for 66% of the respondents in the mental and mixed groups, for 90% in the physical and mixed groups, and for 96% in the physical and mental groups.
Gene_expression (groups) of mixed associated with disease
9) Confidence 0.03 Published 2010 Journal J Occup Rehabil Section Body Doc Link PMC2980635 Disease Relevance 0.46 Pain Relevance 0.07
To evaluate validity, differences among the four groups (healthy, physical, mental and mixed groups) were tested for significance (P ? 
Gene_expression (healthy) of mixed
10) Confidence 0.03 Published 2010 Journal J Occup Rehabil Section Body Doc Link PMC2980635 Disease Relevance 0.19 Pain Relevance 0
Self-classification and classification on the basis of disease codes results in the same classification for 75% of the respondents in the physical, mental and mixed groups, for 66% of the respondents in the mental and mixed groups, for 90% in the physical and mixed groups, and for 96% in the physical and mental groups.
Gene_expression (physical) of mixed associated with disease
11) Confidence 0.03 Published 2010 Journal J Occup Rehabil Section Body Doc Link PMC2980635 Disease Relevance 0.46 Pain Relevance 0.07
Fig. 8Comparative PK profiles in swine (n?
Gene_expression (profiles) of PK
12) Confidence 0.03 Published 2010 Journal Pharm Res Section Body Doc Link PMC3003827 Disease Relevance 0.23 Pain Relevance 0.09
Fig. 6Comparative PK profiles in swine administered 0.7–1 mL of 1 mg/mL commercial naloxone hydrochloride formulation via hMTS (n?
Gene_expression (profiles) of PK associated with narcan
13) Confidence 0.03 Published 2010 Journal Pharm Res Section Body Doc Link PMC3003827 Disease Relevance 0.07 Pain Relevance 0.53
Blood samples collected and analyzed after delivery indicate PK profiles similar to those achieved following administration of the same amount of formulation by subcutaneous injection.


Gene_expression (profiles) of PK in Blood
14) Confidence 0.03 Published 2010 Journal Pharm Res Section Body Doc Link PMC3003827 Disease Relevance 0.16 Pain Relevance 0.05
These findings highlight the importance of understanding the regulation of Kit expression within the melanocyte lineage.
Gene_expression (expression) of lineage in melanocyte
15) Confidence 0.01 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2940735 Disease Relevance 0.72 Pain Relevance 0
To test whether tfap2e is expressed in xanthophores, we processed embryos to simultaneously reveal expression of tfap2e mRNA and Pax7 protein, a marker of the xanthophore lineage [33].
Gene_expression (expression) of lineage in embryos
16) Confidence 0.01 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2940735 Disease Relevance 0.09 Pain Relevance 0
In zebrafish tfap2a mutants or tfap2a MO-injected embryos at 28 hpf, kita expression in the melanophore lineage is reduced to undetectable levels as assessed by in situ hybridization [24], [25].
Gene_expression (expression) of lineage in embryos
17) Confidence 0.01 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2940735 Disease Relevance 0.23 Pain Relevance 0

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