INT88197

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Context Info
Confidence 0.46
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 6.23
Pain Relevance 3.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (ZAK) cell proliferation (ZAK) cell death (ZAK)
nucleus (ZAK) cell cycle (ZAK) response to stress (ZAK)
Anatomy Link Frequency
microglia 2
blood 1
lymphocytes 1
immune systems 1
central grey 1
ZAK (Homo sapiens)
Pain Link Frequency Relevance Heat
Migraine 17 100.00 Very High Very High Very High
Opioid 4 100.00 Very High Very High Very High
antagonist 1 99.88 Very High Very High Very High
potassium channel 10 99.70 Very High Very High Very High
Multiple sclerosis 15 98.68 Very High Very High Very High
sodium channel 70 98.44 Very High Very High Very High
Central grey 6 95.36 Very High Very High Very High
headache 1 89.20 High High
Inflammation 3 88.68 High High
cytokine 4 85.28 High High
Disease Link Frequency Relevance Heat
Headache 18 100.00 Very High Very High Very High
Coronary Artery Disease 2 99.92 Very High Very High Very High
Disease 12 99.06 Very High Very High Very High
Multiple Sclerosis 18 98.68 Very High Very High Very High
Cancer 16 97.88 Very High Very High Very High
Patent Foramen Ovale 1 97.32 Very High Very High Very High
Experimental Autoimmune Encephalomyelitis 3 96.92 Very High Very High Very High
Stroke 14 95.84 Very High Very High Very High
Brain Disease 3 89.24 High High
INFLAMMATION 3 88.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A similar pattern of [(3)H](R)-PK11195 binding in areas containing activated microglia was seen in the CNS of animals with experimental allergic encephalomyelitis (EAE).
PK11195 Binding (binding) of in microglia associated with multiple sclerosis and experimental autoimmune encephalomyelitis
1) Confidence 0.46 Published 2000 Journal Brain Section Abstract Doc Link 11050032 Disease Relevance 0.83 Pain Relevance 0.33
However, there was also significantly increased [(3)H](R)-PK11195 binding on activated microglia outside the histopathologically defined borders of multiple sclerosis plaques and in areas, such as the cerebral central grey matter, that are not normally reported as sites of pathology in multiple sclerosis.
PK11195 Binding (binding) of in central grey associated with multiple sclerosis and central grey
2) Confidence 0.46 Published 2000 Journal Brain Section Abstract Doc Link 11050032 Disease Relevance 0.75 Pain Relevance 0.31
However, Akt inhibition may take place in a SIRT1 –independent way [35], [36] through disruption of interaction between upstream signaling elements such as PI3 Kinase or Grb2 (growth factor receptor-bound protein 2) with further upstream proteins relaying signals directly from the receptor [36].
Kinase Binding (interaction) of
3) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806839 Disease Relevance 0.08 Pain Relevance 0
In areas without identifiable focal pathology, immunocytochemical staining combined with high-resolution emulsion autoradiography demonstrated that the cellular source of [(3)H](R)-PK11195 binding is activated microglia, which frequently retains a ramified morphology.
PK11195 Binding (binding) of in microglia
4) Confidence 0.34 Published 2000 Journal Brain Section Abstract Doc Link 11050032 Disease Relevance 0.78 Pain Relevance 0.34
OBJECTIVES: The preliminary applications of the psychoneuroimmunological knowledges to the treatment of human diseases have confirmed the possibility to amplify IL-2-dependent anticancer immunity by the pineal hormone melatonin (MLT) or by opioid antagonist, such as naltrexone (NTX), which act by activating TH1 lymphocytes or suppressing TH2 lymphocytes, respectively.
MLT Binding (amplify) of in lymphocytes associated with antagonist, disease and opioid
5) Confidence 0.31 Published 2002 Journal Neuro Endocrinol. Lett. Section Abstract Doc Link 12195238 Disease Relevance 0.17 Pain Relevance 0.22
Tumors were perfused with rat donor blood to establish baseline LA uptake values; after 36 min of perfusion, we supplemented the perfusate with MLT, EPA, or CLA and collected arteriovenous whole-blood samples over 5-min intervals for a total perfusion period of 70 min.
MLT Binding (supplemented) of in blood associated with cancer
6) Confidence 0.29 Published 2006 Journal J. Am. Assoc. Lab. Anim. Sci. Section Abstract Doc Link 16642969 Disease Relevance 0.67 Pain Relevance 0
It is now well recognized that a main actor in the continuous interaction between the nervous and immune systems is the pineal hormone MLT.
MLT Binding (recognized) of in immune systems
7) Confidence 0.16 Published 1999 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 10810540 Disease Relevance 0.06 Pain Relevance 0.20
The potassium channels are similarly characterized by GK, PK(V, t), and

.

PK Binding (characterized) of associated with potassium channel
8) Confidence 0.03 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1988852 Disease Relevance 0 Pain Relevance 0.73
The association between migraine and cervical artery dissection (CAD) is reported in recent studies.
cervical artery dissection Binding (association) of in cervical artery associated with coronary artery disease and migraine
9) Confidence 0.00 Published 2004 Journal Neurol. Sci. Section Abstract Doc Link 15549519 Disease Relevance 2.89 Pain Relevance 1.42

General Comments

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