INT88220

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Context Info
Confidence 0.65
First Reported 2000
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 3.08
Pain Relevance 3.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Bdkrb2) plasma membrane (Bdkrb2) signal transducer activity (Bdkrb2)
Anatomy Link Frequency
hypothalamus 2
nerve 1
peripheral nerve 1
ganglia 1
Bdkrb2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
b2 receptor 16 100.00 Very High Very High Very High
Sciatic nerve 4 99.52 Very High Very High Very High
B1 receptor 8 99.14 Very High Very High Very High
Eae 2 99.06 Very High Very High Very High
Peripheral nerve injury 6 98.04 Very High Very High Very High
bradykinin 9 95.96 Very High Very High Very High
Analgesic 6 94.72 High High
antagonist 12 92.56 High High
Inflammation 4 90.16 High High
Hyperalgesia 4 89.60 High High
Disease Link Frequency Relevance Heat
Injury 2 99.06 Very High Very High Very High
Hypertension 22 98.48 Very High Very High Very High
Nervous System Injury 10 97.60 Very High Very High Very High
Hypersensitivity 4 94.48 High High
Neuropathic Pain 10 93.80 High High
INFLAMMATION 4 90.16 High High
Hyperalgesia 7 89.60 High High
Diabetes Mellitus 2 88.36 High High
Pain 3 73.76 Quite High
Coagulation Disorder 1 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Kinin B1 and B2 receptor (R) gene expression (mRNA) is increased in the sensory system after peripheral nerve injury.
Transcription (expression) of B2 receptor in peripheral nerve associated with nervous system injury, b2 receptor and peripheral nerve injury
1) Confidence 0.65 Published 2008 Journal Int. Immunopharmacol. Section Abstract Doc Link 18182225 Disease Relevance 0.25 Pain Relevance 0.40
Kinin B1 and B2 receptor mRNA expression in the hypothalamus of spontaneously hypertensive rats.
Transcription (expression) of B2 receptor in hypothalamus associated with hypertension and b2 receptor
2) Confidence 0.42 Published 2002 Journal Can. J. Physiol. Pharmacol. Section Title Doc Link 12025958 Disease Relevance 0.80 Pain Relevance 0.32
At all ages tested, B2 receptor mRNA levels in the hypothalamus of SHR were higher than age-matched WKY rats (p < 0.001).
Transcription (levels) of B2 receptor in hypothalamus associated with b2 receptor
3) Confidence 0.42 Published 2002 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 12025958 Disease Relevance 0.96 Pain Relevance 0.39
Forty eight-hours following chronic constriction injury to a rat sciatic nerve there was an increased expression of B2 receptor mRNA in the lumbar dorsal root ganglia ipsilateral to the site of nerve injury.
Transcription (expression) of B2 receptor in nerve associated with nervous system injury, eae, injury, b2 receptor and sciatic nerve
4) Confidence 0.38 Published 2000 Journal Pain Section Abstract Doc Link 10812256 Disease Relevance 0.56 Pain Relevance 0.95
At 14 days following surgery there was also an ipsilateral increase of B1 receptor mRNA as well as a contralateral increased expression of B2 receptor mRNA.
Transcription (expression) of B2 receptor associated with b1 receptor and b2 receptor
5) Confidence 0.38 Published 2000 Journal Pain Section Abstract Doc Link 10812256 Disease Relevance 0.52 Pain Relevance 1.16
Expression of both B1 and B2 receptor mRNAs was detected in the lumbar dorsal ganglia ipsilateral to the site of the nerve injury.
Transcription (detected) of B2 receptor in ganglia
6) Confidence 0.14 Published 2003 Journal Inflamm. Res. Section Body Doc Link 12755382 Disease Relevance 0 Pain Relevance 0

General Comments

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