INT88221

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Context Info
Confidence 0.36
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 3.35
Pain Relevance 3.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Bdkrb2) plasma membrane (Bdkrb2) signal transducer activity (Bdkrb2)
Anatomy Link Frequency
nerve 2
Bdkrb2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
B1 receptor 97 100.00 Very High Very High Very High
b2 receptor 10 100.00 Very High Very High Very High
Sciatic nerve 3 99.72 Very High Very High Very High
Eae 3 99.26 Very High Very High Very High
Peripheral nerve injury 6 96.24 Very High Very High Very High
cytokine 9 96.08 Very High Very High Very High
Analgesic 9 94.72 High High
bradykinin 32 93.08 High High
antagonist 28 92.56 High High
fibrosis 1 83.28 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 3 99.68 Very High Very High Very High
Injury 3 99.26 Very High Very High Very High
Nervous System Injury 9 97.56 Very High Very High Very High
Common Cold 1 95.20 Very High Very High Very High
Hypersensitivity 6 94.88 High High
Aging 1 94.28 High High
Neuropathic Pain 32 94.20 High High
Asthma 43 94.00 High High
Diabetes Mellitus 17 90.24 High High
Renal Disease 1 87.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Forty eight-hours following chronic constriction injury to a rat sciatic nerve there was an increased expression of B2 receptor mRNA in the lumbar dorsal root ganglia ipsilateral to the site of nerve injury.
Positive_regulation (increased) of Gene_expression (expression) of B2 receptor in nerve associated with nervous system injury, eae, injury, b2 receptor and sciatic nerve
1) Confidence 0.36 Published 2000 Journal Pain Section Abstract Doc Link 10812256 Disease Relevance 0.56 Pain Relevance 0.95
At 14 days following surgery there was also an ipsilateral increase of B1 receptor mRNA as well as a contralateral increased expression of B2 receptor mRNA.
Positive_regulation (increase) of Gene_expression (expression) of B2 receptor associated with b1 receptor and b2 receptor
2) Confidence 0.36 Published 2000 Journal Pain Section Abstract Doc Link 10812256 Disease Relevance 0.53 Pain Relevance 1.17
At 14 days following surgery there was also an ipsilateral increase of B1 receptor mRNA as well as a contralateral increased expression of B2 receptor mRNA.
Positive_regulation (increased) of Gene_expression (expression) of B2 receptor associated with b1 receptor and b2 receptor
3) Confidence 0.36 Published 2000 Journal Pain Section Abstract Doc Link 10812256 Disease Relevance 0.52 Pain Relevance 1.16
Renal expression of B2R is also significantly enhanced in B1R knockout mice [75], suggesting that the absence of one kinin receptor is compensated by the over-expression of the remaining kinin receptor.
Positive_regulation (enhanced) of Gene_expression (expression) of B2R associated with targeted disruption and b1 receptor
4) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 1.48 Pain Relevance 0.45
are both able to increase B2 bradykinin receptor expression in ASM [174,175].
Positive_regulation (increase) of Gene_expression (expression) of B2 bradykinin receptor associated with b2 receptor
5) Confidence 0.04 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0.27 Pain Relevance 0.18

General Comments

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