INT88222

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Context Info
Confidence 0.47
First Reported 2000
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.32
Pain Relevance 2.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Bdkrb2) plasma membrane (Bdkrb2) signal transducer activity (Bdkrb2)
Anatomy Link Frequency
nerve 2
peripheral nerve 2
Bdkrb2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
b2 receptor 7 100.00 Very High Very High Very High
Sciatic nerve 4 99.72 Very High Very High Very High
B1 receptor 4 99.34 Very High Very High Very High
Eae 2 99.26 Very High Very High Very High
Peripheral nerve injury 6 98.84 Very High Very High Very High
Analgesic 6 94.72 High High
bradykinin 6 92.80 High High
antagonist 10 92.56 High High
Spinal cord 2 90.08 High High
Pain 7 75.36 Quite High
Disease Link Frequency Relevance Heat
Injury 2 99.26 Very High Very High Very High
Nervous System Injury 8 98.40 Very High Very High Very High
Hypersensitivity 4 94.88 High High
Neuropathic Pain 10 94.20 High High
Pain 3 75.36 Quite High
Hyperalgesia 3 32.64 Quite Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Kinin B1 and B2 receptor (R) gene expression (mRNA) is increased in the sensory system after peripheral nerve injury.
Positive_regulation (increased) of Transcription (expression) of B2 receptor in peripheral nerve associated with nervous system injury, b2 receptor and peripheral nerve injury
1) Confidence 0.47 Published 2008 Journal Int. Immunopharmacol. Section Abstract Doc Link 18182225 Disease Relevance 0.25 Pain Relevance 0.40
Forty eight-hours following chronic constriction injury to a rat sciatic nerve there was an increased expression of B2 receptor mRNA in the lumbar dorsal root ganglia ipsilateral to the site of nerve injury.
Positive_regulation (increased) of Transcription (expression) of B2 receptor in nerve associated with nervous system injury, eae, injury, b2 receptor and sciatic nerve
2) Confidence 0.33 Published 2000 Journal Pain Section Abstract Doc Link 10812256 Disease Relevance 0.56 Pain Relevance 0.95
At 14 days following surgery there was also an ipsilateral increase of B1 receptor mRNA as well as a contralateral increased expression of B2 receptor mRNA.
Positive_regulation (increased) of Transcription (expression) of B2 receptor associated with b1 receptor and b2 receptor
3) Confidence 0.33 Published 2000 Journal Pain Section Abstract Doc Link 10812256 Disease Relevance 0.52 Pain Relevance 1.16

General Comments

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