INT88223

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Context Info
Confidence 0.69
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 17
Total Number 17
Disease Relevance 13.94
Pain Relevance 11.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Bdkrb2) plasma membrane (Bdkrb2) signal transducer activity (Bdkrb2)
Anatomy Link Frequency
hypothalamus 2
trigeminal ganglia 1
nerve 1
peripheral nerve 1
smooth muscle cells 1
Bdkrb2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bradykinin 480 100.00 Very High Very High Very High
agonist 329 100.00 Very High Very High Very High
b2 receptor 217 100.00 Very High Very High Very High
dorsal root ganglion 269 99.80 Very High Very High Very High
B1 receptor 199 99.80 Very High Very High Very High
Sciatic nerve 5 99.52 Very High Very High Very High
Eae 5 99.06 Very High Very High Very High
Arthritis 152 98.68 Very High Very High Very High
Peripheral nerve injury 7 98.04 Very High Very High Very High
cytokine 18 96.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 270 99.80 Very High Very High Very High
Injury 2 99.06 Very High Very High Very High
Targeted Disruption 4 99.04 Very High Very High Very High
Hypertension 27 98.76 Very High Very High Very High
Arthritis 168 98.68 Very High Very High Very High
Malignant Neoplastic Disease 12 98.40 Very High Very High Very High
Nervous System Injury 12 97.60 Very High Very High Very High
Glioma 225 95.56 Very High Very High Very High
Common Cold 1 95.20 Very High Very High Very High
Cancer 303 94.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although bradykinin B2 receptors are ubiquitously expressed, these receptors are over-expressed in malignant tumors [12-15].
Gene_expression (expressed) of bradykinin B2 associated with malignant neoplastic disease and bradykinin
1) Confidence 0.69 Published 2009 Journal J Transl Med Section Body Doc Link PMC2689161 Disease Relevance 1.05 Pain Relevance 0.41
We found that bradykinin increased the TRPA1 currents evoked by allyl isothiocyanate (AITC) or cinnamaldehyde in HEK293 cells expressing TRPA1 and bradykinin receptor 2 (B2R).
Gene_expression (expressing) of bradykinin receptor 2 associated with bradykinin
2) Confidence 0.69 Published 2008 Journal Brain Section Abstract Doc Link 18356188 Disease Relevance 0.48 Pain Relevance 0.73
We found that bradykinin increased the TRPA1 currents evoked by allyl isothiocyanate (AITC) or cinnamaldehyde in HEK293 cells expressing TRPA1 and bradykinin receptor 2 (B2R).
Gene_expression (expressing) of B2R associated with bradykinin
3) Confidence 0.69 Published 2008 Journal Brain Section Abstract Doc Link 18356188 Disease Relevance 0.48 Pain Relevance 0.73
Western blot analysis of crude subcellular fractions and lipid raft preparations of cultured rat trigeminal ganglia demonstrate similar expression profiles between EP24.15/16 and B2R on a subcellular level.
Gene_expression (expression) of B2R in trigeminal ganglia
4) Confidence 0.66 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16515556 Disease Relevance 0.24 Pain Relevance 0.61
We conclude that B1 and B2 receptor mRNA are differentially expressed in the hypothalamus of SHR and may play different roles in the pathogenesis of hypertension: upregulation of B2 receptor mRNA from early age may participate in the pathogenesis of hypertension, whereas an upregulation of B1 receptor mRNA in the established phase of hypertension may reflect an epiphenomenon in essential hypertension.
Gene_expression (expressed) of B2 receptor in hypothalamus associated with b1 receptor, hypertension and b2 receptor
5) Confidence 0.61 Published 2002 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 12025958 Disease Relevance 1.13 Pain Relevance 0.40
Kinin B1 and B2 receptor (R) gene expression (mRNA) is increased in the sensory system after peripheral nerve injury.
Gene_expression (expression) of B2 receptor in peripheral nerve associated with nervous system injury, b2 receptor and peripheral nerve injury
6) Confidence 0.57 Published 2008 Journal Int. Immunopharmacol. Section Abstract Doc Link 18182225 Disease Relevance 0.25 Pain Relevance 0.40
Bradykinin B2 receptor agonist peptides were synthesized based on the known amino acid sequences (Peptides International, Inc., Louisville, KY)[11,20].
Gene_expression (synthesized) of Bradykinin B2 associated with agonist and b2 receptor
7) Confidence 0.53 Published 2009 Journal J Transl Med Section Body Doc Link PMC2689161 Disease Relevance 0.59 Pain Relevance 0.58
Bradykinin B2 receptor agonists are vasodilator peptides that act on the G-protein coupled bradykinin B2 receptors expressed on the endothelial and smooth muscle cells of the microvasculature supplying most tissues and organs[10,11].
Gene_expression (expressed) of bradykinin B2 in smooth muscle cells associated with agonist, b2 receptor and bradykinin
8) Confidence 0.53 Published 2009 Journal J Transl Med Section Body Doc Link PMC2689161 Disease Relevance 0.98 Pain Relevance 0.33
Kinin B1 and B2 receptor mRNA expression in the hypothalamus of spontaneously hypertensive rats.
Gene_expression (expression) of B2 receptor in hypothalamus associated with hypertension and b2 receptor
9) Confidence 0.53 Published 2002 Journal Can. J. Physiol. Pharmacol. Section Title Doc Link 12025958 Disease Relevance 0.80 Pain Relevance 0.32
Forty eight-hours following chronic constriction injury to a rat sciatic nerve there was an increased expression of B2 receptor mRNA in the lumbar dorsal root ganglia ipsilateral to the site of nerve injury.
Gene_expression (expression) of B2 receptor in nerve associated with nervous system injury, eae, injury, b2 receptor and sciatic nerve
10) Confidence 0.48 Published 2000 Journal Pain Section Abstract Doc Link 10812256 Disease Relevance 0.56 Pain Relevance 0.95
At 14 days following surgery there was also an ipsilateral increase of B1 receptor mRNA as well as a contralateral increased expression of B2 receptor mRNA.
Gene_expression (expression) of B2 receptor associated with b1 receptor and b2 receptor
11) Confidence 0.48 Published 2000 Journal Pain Section Abstract Doc Link 10812256 Disease Relevance 0.52 Pain Relevance 1.16
The B2R is widely and constitutively expressed in central and peripheral tissues and is activated by its preferential agonists bradykinin (BK) and Lys-BK.
Gene_expression (expressed) of B2R associated with agonist and bradykinin
12) Confidence 0.45 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2913947 Disease Relevance 2.07 Pain Relevance 1.32
Renal expression of B2R is also significantly enhanced in B1R knockout mice [75], suggesting that the absence of one kinin receptor is compensated by the over-expression of the remaining kinin receptor.
Gene_expression (expression) of B2R associated with targeted disruption and b1 receptor
13) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 1.48 Pain Relevance 0.45
The proportion of DRG neurones expressing bradykinin 2 receptors was slightly upregulated in the presence of FLS cells from normal joints but upregulation was more pronounced in DRG neurones co-cultured with FLS cells from acutely inflamed joints.
Gene_expression (expressing) of bradykinin 2 in DRG associated with dorsal root ganglion and bradykinin
14) Confidence 0.21 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC1860064 Disease Relevance 1.24 Pain Relevance 0.91
Detection of bradykinin 2 receptors
Gene_expression (receptors) of bradykinin 2 associated with bradykinin
15) Confidence 0.18 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860064 Disease Relevance 0.29 Pain Relevance 0.50
Thirdly, and unexpectedly, only the B2 receptor, not the B1 receptor, was upregulated.
Neg (not) Gene_expression (not) of B2 receptor associated with b1 receptor and b2 receptor
16) Confidence 0.13 Published 2000 Journal Arthritis Res Section Body Doc Link PMC17819 Disease Relevance 1.53 Pain Relevance 1.47
are both able to increase B2 bradykinin receptor expression in ASM [174,175].
Gene_expression (expression) of B2 bradykinin receptor associated with b2 receptor
17) Confidence 0.06 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0.27 Pain Relevance 0.18

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