INT88225

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Context Info
Confidence 0.61
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 1.51
Pain Relevance 2.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Ugt1a1) enzyme binding (Ugt1a1)
Anatomy Link Frequency
hypothalamus 1
liver 1
fibroblasts 1
ganglia 1
kidney 1
Ugt1a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 3 99.70 Very High Very High Very High
nociceptor 1 99.70 Very High Very High Very High
bradykinin 5 99.68 Very High Very High Very High
Antinociceptive 1 98.68 Very High Very High Very High
antagonist 6 97.36 Very High Very High Very High
Neuropathic pain 1 96.00 Very High Very High Very High
Morphine 4 94.28 High High
Peripheral nerve injury 2 91.00 High High
Hyperalgesia 3 90.72 High High
Inflammation 2 90.16 High High
Disease Link Frequency Relevance Heat
Hypertension 13 97.80 Very High Very High Very High
Neuropathic Pain 2 96.00 Very High Very High Very High
Hypersensitivity 2 92.08 High High
Diabetes Mellitus 2 91.80 High High
Hyperalgesia 3 90.72 High High
Nervous System Injury 5 90.56 High High
INFLAMMATION 3 90.16 High High
Injury 5 88.04 High High
Acute-phase Reaction 2 75.00 Quite High
Coagulation Disorder 1 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Endotoxin administration was associated with a time-dependent decrease in UGT1A1, UGT1A6, UGT2B1, and UGT2B3 mRNA levels in liver and kidney tissues.
Transcription (levels) of UGT1A1 in kidney
1) Confidence 0.61 Published 2008 Journal Drug Metab Lett Section Abstract Doc Link 19356101 Disease Relevance 0.07 Pain Relevance 0.31
Increased mRNA expression of the B1 and B2 bradykinin receptors and antinociceptive effects of their antagonists in an animal model of neuropathic pain.
Transcription (expression) of B1 associated with nociceptor, antagonist, neuropathic pain, antinociceptive and bradykinin
2) Confidence 0.33 Published 2000 Journal Pain Section Title Doc Link 10812256 Disease Relevance 0.54 Pain Relevance 1.47
Therefore, we analyzed the mRNA expression of B1 and B2 receptors in the hypothalamus of spontaneously hypertensive rats (SHR) by RT-PCR.
Spec (analyzed) Transcription (expression) of B1 in hypothalamus associated with hypertension
3) Confidence 0.21 Published 2002 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 12025958 Disease Relevance 0.82 Pain Relevance 0.28
Endotoxin administration was associated with a time-dependent decrease in UGT1A1, UGT1A6, UGT2B1, and UGT2B3 mRNA levels in liver and kidney tissues.
Transcription (levels) of UGT1A1 in liver
4) Confidence 0.21 Published 2008 Journal Drug Metab Lett Section Abstract Doc Link 19356101 Disease Relevance 0.07 Pain Relevance 0.31
Expression of both B1 and B2 receptor mRNAs was detected in the lumbar dorsal ganglia ipsilateral to the site of the nerve injury.
Transcription (detected) of B1 in ganglia
5) Confidence 0.21 Published 2003 Journal Inflamm. Res. Section Body Doc Link 12755382 Disease Relevance 0 Pain Relevance 0
The targets of miR-539 obtained by computational analyses include matrix metallopeptidase 20, fibroblast growth factor 14, clathrin, light polypeptide, osteoprotegerin and transcription factors like forkhead box B1, which may have roles in cardiac remodeling. miR-21 were shown to regulate the ERK-MAP kinase signalling pathway in cardiac fibroblasts, which has role on global cardiac structure and function [24].
Transcription (transcription) of B1 in fibroblasts
6) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009730 Disease Relevance 0 Pain Relevance 0.03

General Comments

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