INT88237

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Context Info
Confidence 0.65
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 5.46
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
endothelial cell 1
finger 1
ducts 1
Gbp1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 11 98.92 Very High Very High Very High
Inflammation 11 98.52 Very High Very High Very High
spinal inflammation 1 98.36 Very High Very High Very High
Glutamate receptor 1 96.92 Very High Very High Very High
Inflammatory response 3 94.76 High High
Somatostatin 4 93.40 High High
Neurotransmitter 2 84.24 Quite High
Limbic system 1 27.52 Quite Low
ischemia 1 22.32 Low Low
Opioid 1 19.52 Low Low
Disease Link Frequency Relevance Heat
Neuroma 79 100.00 Very High Very High Very High
Salivary Gland Disease 8 100.00 Very High Very High Very High
Ankylosis 2 100.00 Very High Very High Very High
Sprains And Strains 96 98.92 Very High Very High Very High
INFLAMMATION 15 98.52 Very High Very High Very High
Low Back Pain 2 98.36 Very High Very High Very High
Aging 57 98.14 Very High Very High Very High
Precocious Puberty 38 98.04 Very High Very High Very High
Epilepsy 1 94.40 High High
Polyostotic Fibrous Dysplasia 9 93.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several genes related to senescence were found to be significantly upregulated in senescent cells vs. non-senescent cells: p38 (MPAK14), RB-Associated KRAB zinc finger, Discoidin, CUB and LCCL domain, growth arrest and DNA-damage inducible beta, inhibitor of growth family member 5 (p28ING5), sphingosine-1-phosphate receptor 2 and somatostatin receptor 3.
Gene_expression (finger) of MPA in finger associated with aging and somatostatin
1) Confidence 0.65 Published 2010 Journal BMC Biotechnol Section Body Doc Link PMC2828399 Disease Relevance 0.65 Pain Relevance 0.12
The finding that GBP-1 expression is inhibited by potent activators of endothelial cell proliferation such as VEGF and bFGF [52], leads to the hypothesis that GTPases are in the cross-road of inflammation and vascular proliferation.
Gene_expression (expression) of GBP-1 in endothelial cell associated with inflammation
2) Confidence 0.43 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2212656 Disease Relevance 0.74 Pain Relevance 0.27
Relatively large numbers of guanine nucleotide-binding protein (G protein) isoforms and Ras subfamily of GTPases were identified; G(s)?
Gene_expression (isoforms) of guanine nucleotide-binding protein
3) Confidence 0.25 Published 2007 Journal Proteome Sci Section Body Doc Link PMC2045652 Disease Relevance 0.05 Pain Relevance 0.12
It is due to post-zygotic-activating recurrent mutations in the guanine-nucleotide-binding protein (G protein) ?
Gene_expression (mutations) of guanine-nucleotide-binding protein
4) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892512 Disease Relevance 2.00 Pain Relevance 0
In HMF cells EC50-values of ribavirin and MPA were 250 ?
Gene_expression (values) of MPA
5) Confidence 0.12 Published 2003 Journal BMC Microbiol Section Body Doc Link PMC317291 Disease Relevance 0.17 Pain Relevance 0
This was supported by the fact that no histologic differences with respect to MPA-induced development of convoluted granular ducts of the salivary glands, the source of EGF, were found across strains.
Gene_expression (source) of MPA in ducts associated with salivary gland disease and sprains and strains
6) Confidence 0.11 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1868922 Disease Relevance 0.76 Pain Relevance 0
Interestingly, PR-B was highly expressed in MPA and progesterone treated BALB/c (P < 0.001 and P < 0.05, respectively) and C57BL/6 mice (P < 0.01; Figure 4b), and followed a similar pattern of expression as ER-?.
Gene_expression (expressed) of MPA
7) Confidence 0.11 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1868922 Disease Relevance 0.29 Pain Relevance 0
OBJECTIVE: To investigate whether HLA-B27 influences the expression of murine progressive ankylosis (MPA), a single-gene autosomal recessive mouse model of ankylosing spondylitis that arises in mice homozygous for the ank gene.
Gene_expression (expression) of MPA associated with spinal inflammation and ankylosis
8) Confidence 0.10 Published 2000 Journal J. Rheumatol. Section Abstract Doc Link 10813297 Disease Relevance 0.27 Pain Relevance 0.10
Calpain small subunit 1 displayed increased expression in the neuromas, whilst guanine nucleotide-binding protein Go subunit alpha 2, ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1), gamma-synuclein, mimecan precursor were all down-regulated (Table 2).
Gene_expression (expression) of guanine nucleotide-binding protein associated with neuroma
9) Confidence 0.06 Published 2008 Journal Mol Pain Section Body Doc Link PMC2525634 Disease Relevance 0.51 Pain Relevance 0

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