INT8824

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Context Info
Confidence 0.62
First Reported 1980
Last Reported 2011
Negated 15
Speculated 18
Reported most in Abstract
Documents 95
Total Number 115
Disease Relevance 15.70
Pain Relevance 43.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Vip)
Anatomy Link Frequency
spinal 5
neurons 5
chromaffin cells 4
plasma 4
pituitary 4
Vip (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 137 100.00 Very High Very High Very High
Neuropeptide 93 100.00 Very High Very High Very High
Enkephalin 78 100.00 Very High Very High Very High
Acupuncture 53 100.00 Very High Very High Very High
Somatostatin 53 100.00 Very High Very High Very High
antagonist 44 100.00 Very High Very High Very High
Cholecystokinin 43 100.00 Very High Very High Very High
Spinal cord 35 100.00 Very High Very High Very High
Calcitonin gene-related peptide 35 100.00 Very High Very High Very High
agonist 22 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 27 100.00 Very High Very High Very High
Nociception 4 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 19 99.98 Very High Very High Very High
Aging 5 99.98 Very High Very High Very High
Obesity 10 99.96 Very High Very High Very High
Depression 10 99.72 Very High Very High Very High
Functional Bowel Disorder 11 99.48 Very High Very High Very High
Nervous System Injury 2 99.24 Very High Very High Very High
INFLAMMATION 124 99.22 Very High Very High Very High
Heart Rate Under Development 8 99.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Many studies have documented that the VIP levels can be modulated by acupuncture.
Regulation (modulated) of VIP associated with acupuncture
1) Confidence 0.62 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952296 Disease Relevance 0.94 Pain Relevance 0.88
DMPP-stimulated vasoactive intestinal peptide (VIP) release in dispersed ganglia was inhibited by [Met]enkephalin and bicuculline and augmented by naloxone and GABA, implying that inhibitory opioid and stimulatory GABA neurons regulate the activity of VIP interneurons.
Regulation (regulate) of VIP in neurons associated with gaba, narcan, enkephalin and opioid
2) Confidence 0.61 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9815026 Disease Relevance 0 Pain Relevance 1.03
The aim of the present study was to investigate the roles of vasoactive intestinal peptide (VIP) and tachykinins in this reflex(es).
Spec (investigate) Regulation (roles) of VIP
3) Confidence 0.55 Published 1990 Journal Acta Physiol. Scand. Section Abstract Doc Link 1972607 Disease Relevance 0.17 Pain Relevance 0.22
To determine the mechanism by which immobilization and head-up tilt under inactin anesthesia increase plasma renin activity (PRA), the effect of these stimuli on plasma levels of vasoactive intestinal polypeptide (VIP) were measured and the effect of the beta-adrenergic blocking drug, propranolol on the response of plasma renin activity determined.
Regulation (effect) of VIP in plasma associated with anesthesia
4) Confidence 0.53 Published 1988 Journal Neuropharmacology Section Abstract Doc Link 3072488 Disease Relevance 0 Pain Relevance 0.16
Regulation of enkephalin, VIP, and chromogranin biosynthesis in actively secreting chromaffin cells.
Regulation (Regulation) of VIP in chromaffin cells associated with enkephalin
5) Confidence 0.46 Published 1987 Journal Ann. N. Y. Acad. Sci. Section Title Doc Link 3035984 Disease Relevance 0 Pain Relevance 0.38
The effects of acute infusion of vasoactive intestinal polypeptide (VIP) and hypoxemia on splanchnic circulation were examined in 35 awake Sprague-Dawley rats.
Spec (examined) Regulation (effects) of VIP
6) Confidence 0.45 Published 1988 Journal J. Pediatr. Surg. Section Abstract Doc Link 3236187 Disease Relevance 0 Pain Relevance 0.08
Capsaicin treatment did not affect the increased concentration of VIP-LI in the dorsal root ganglia.
Neg (not) Regulation (affect) of VIP in dorsal root ganglia associated with qutenza
7) Confidence 0.45 Published 1995 Journal Neuropeptides Section Abstract Doc Link 7566511 Disease Relevance 0.53 Pain Relevance 0.50
Another alternative mechanism responsible for the VIP function is the modulation of autoreactive T cell activation/expansion through inducing a Th2-type response and expanding CD4+CD25+ regulatory T cells [21].
Regulation (responsible) of VIP in regulatory T cells
8) Confidence 0.45 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952296 Disease Relevance 1.29 Pain Relevance 0.97
We examined the mechanisms of effects of vasoactive intestinal polypeptide (VIP), pituitary adenylate cyclase activating polypeptide (PACAP) 27 and PACAP38 on spontaneously occurring pressure waves in ex vivo perfused rat duodenum.
Spec (examined) Regulation (effects) of VIP in duodenum
9) Confidence 0.45 Published 1999 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 10354348 Disease Relevance 0 Pain Relevance 0.22
In muscle strips, VIP stimulated basal and augmented somatostatin-induced substance P (SP) release; the somatostatin-induced increase in SP release was inhibited by VIP-(10-28) and NG-nitro-L-arginine, implying that excitatory VIP neurons regulate tachykinin motoneurons innervating longitudinal muscle.
Regulation (regulate) of VIP in longitudinal muscle associated with somatostatin and substance p
10) Confidence 0.45 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9815026 Disease Relevance 0 Pain Relevance 1.12
The effects of beta-endorphin and vasoactive intestinal peptide (VIP) on the body shaking response to ice water immersion were observed in anesthetized rats.
Regulation (effects) of VIP in body
11) Confidence 0.45 Published 1983 Journal Jpn. J. Physiol. Section Abstract Doc Link 6199539 Disease Relevance 0 Pain Relevance 0.12
The effects of beta-endorphin and vasoactive intestinal peptide (VIP) on the body shaking response to ice water immersion were observed in anesthetized rats.
Regulation (effects) of vasoactive intestinal peptide in body
12) Confidence 0.45 Published 1983 Journal Jpn. J. Physiol. Section Abstract Doc Link 6199539 Disease Relevance 0 Pain Relevance 0.12
The effect of vasoactive intestinal polypeptide (VIP) on uterine smooth muscle electrical and mechanical activity in non-pregnant estradiol-treated rabbits was investigated using in vivo and in vitro methods.
Regulation (effect) of VIP in uterine smooth muscle
13) Confidence 0.45 Published 1981 Journal Acta Physiol. Scand. Section Abstract Doc Link 6947684 Disease Relevance 0 Pain Relevance 0.03
The effect of vasoactive intestinal polypeptide (VIP) on uterine smooth muscle electrical and mechanical activity in non-pregnant estradiol-treated rabbits was investigated using in vivo and in vitro methods.
Regulation (effect) of vasoactive intestinal polypeptide in uterine smooth muscle
14) Confidence 0.45 Published 1981 Journal Acta Physiol. Scand. Section Abstract Doc Link 6947684 Disease Relevance 0 Pain Relevance 0.03
Increased levels of GMAP, VIP and nitric oxide synthase, and their mRNAs, in lumbar dorsal root ganglia of the rat following systemic resiniferatoxin treatment.
Regulation (levels) of VIP in dorsal root ganglia
15) Confidence 0.44 Published 1995 Journal Neuroreport Section Title Doc Link 8595209 Disease Relevance 0 Pain Relevance 0.13
Effects of vasoactive intestinal polypeptide (VIP) and pituitary adenylate cyclase activating polypeptide (PACAP) on the spontaneous release of acetylcholine from the rat hippocampus by brain microdialysis.
Regulation (Effects) of VIP in pituitary associated with neuropeptide and hippocampus
16) Confidence 0.44 Published 1993 Journal Brain Res. Section Title Doc Link 8334515 Disease Relevance 0 Pain Relevance 0.30
The effect of vasoactive intestinal polypeptide (VIP) on cerebral arterioles was examined in anesthetized cats equipped with an acutely implanted cranial window for the observation of the pial microcirculation.
Regulation (effect) of VIP in cranial
17) Confidence 0.43 Published 1980 Journal Am. J. Physiol. Section Abstract Doc Link 7446750 Disease Relevance 0.08 Pain Relevance 0
To elucidate the relationship between VIP and the adrenergic system and its role in the mechanism of disturbed prolactin (PRL) and growth hormone (GH) release in obesity, serum VIP, GH, and PRL concentrations in response to alpha 2-adrenergic receptor agonist-clonidine were measured.
Regulation (concentrations) of serum VIP associated with obesity, agonist and clonidine
18) Confidence 0.41 Published 1991 Journal Metab. Clin. Exp. Section Abstract Doc Link 1849217 Disease Relevance 0.66 Pain Relevance 0.31
The effects of vasoactive intestinal polypeptide (VIP) on the hypothalamic-pituitary-thyroid axis in rats were studied.
Regulation (effects) of VIP in thyroid
19) Confidence 0.41 Published 1984 Journal Endocrinol. Exp. Section Abstract Doc Link 6430673 Disease Relevance 0 Pain Relevance 0
The aim of the present study was to investigate the roles of vasoactive intestinal peptide (VIP) and tachykinins in this reflex(es).
Spec (investigate) Regulation (roles) of vasoactive intestinal peptide
20) Confidence 0.41 Published 1990 Journal Acta Physiol. Scand. Section Abstract Doc Link 1972607 Disease Relevance 0.17 Pain Relevance 0.22

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