INT88241

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Context Info
Confidence 0.45
First Reported 2000
Last Reported 2005
Negated 0
Speculated 2
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 1.71
Pain Relevance 2.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Ptgs1) aging (Ptgs1) Golgi apparatus (Ptgs1)
endoplasmic reticulum (Ptgs1) cytoplasm (Ptgs1) lipid binding (Ptgs1)
Anatomy Link Frequency
spinal cord 2
PGE2 2
afferent neurons 2
Ptgs1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 11 99.98 Very High Very High Very High
Hyperalgesia 10 99.90 Very High Very High Very High
excitatory amino acid 4 99.90 Very High Very High Very High
Spinal cord 12 99.68 Very High Very High Very High
COX2 2 99.42 Very High Very High Very High
electroacupuncture 9 98.94 Very High Very High Very High
substance P 8 98.04 Very High Very High Very High
dorsal root ganglion 7 92.44 High High
tail-flick 1 87.04 High High
COX-2 inhibitor 1 48.72 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 8 99.98 Very High Very High Very High
Hyperalgesia 10 99.90 Very High Very High Very High
Pressure And Volume Under Development 5 99.56 Very High Very High Very High
Ganglion Cysts 7 91.96 High High
Nociception 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is assumed that NO produced by excitatory amino acids may increase prostaglandin production by cyclooxygenase activation.
Spec (may) Positive_regulation (increase) of Positive_regulation (activation) of cyclooxygenase associated with excitatory amino acid
1) Confidence 0.45 Published 2000 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 10813554 Disease Relevance 0.47 Pain Relevance 0.82
At 3 h after carrageenan-injection, we investigated whether the effects of a 2 Hz EA on a carrageenan-induced edema and hyperalgesia are associated with peripheral cyclooxygenase (COX) mRNA induction and prostaglandin E2 (PGE2) synthesis.
Spec (whether) Positive_regulation (associated) of Spec (whether) Positive_regulation (induction) of cyclooxygenase in PGE2 associated with pressure and volume under development, hyperalgesia and electroacupuncture
2) Confidence 0.16 Published 2005 Journal Int. J. Mol. Med. Section Abstract Doc Link 15942684 Disease Relevance 0.76 Pain Relevance 0.78
Peripheral inflammation causes upregulation of cyclooxygenase in the spinal cord and subsequent increase in prostaglandin biosynthesis.
Positive_regulation (causes) of Positive_regulation (upregulation) of cyclooxygenase in spinal cord associated with inflammation and spinal cord
3) Confidence 0.15 Published 2003 Journal Neuroscience Section Abstract Doc Link 12617945 Disease Relevance 0.10 Pain Relevance 0.14
Nitric oxide synergistically potentiates interleukin-1 beta-induced increase of cyclooxygenase-2 mRNA levels, resulting in the facilitation of substance P release from primary afferent neurons: involvement of cGMP-independent mechanisms.
Positive_regulation (potentiates) of Positive_regulation (increase) of cyclooxygenase in afferent neurons associated with cox2 and substance p
4) Confidence 0.11 Published 2002 Journal Neuropharmacology Section Title Doc Link 12384172 Disease Relevance 0.38 Pain Relevance 0.51

General Comments

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